{"id":"premixed-bioceramic-material","safety":{"commonSideEffects":[{"rate":null,"effect":"Infection at implant site"},{"rate":null,"effect":"Delayed bone healing"},{"rate":null,"effect":"Material displacement"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bioceramic materials are composed of ceramic compounds (such as hydroxyapatite, tricalcium phosphate, or their combinations) that mimic the mineral phase of natural bone. When premixed in a ready-to-use formulation, these materials serve as a three-dimensional scaffold that facilitates bone cell attachment, proliferation, and differentiation while gradually resorbing and being replaced by new bone tissue.","oneSentence":"Premixed bioceramic material provides a biocompatible scaffold that promotes bone regeneration and integration through osteoconductive and potentially osteoinductive properties.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:30:09.003Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bone defect filling and regeneration in orthopedic and dental applications"},{"name":"Periodontal bone loss treatment"}]},"trialDetails":[{"nctId":"NCT05811403","phase":"NA","title":"Epigallocatechin Gallate (EGCG) as a Flushing Agent During Full Pulpotomy in Mature Permanent Molars With Irreversible Pulpitis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Cairo University","startDate":"2023-07-01","conditions":"Irreversible Pulpitis","enrollment":64},{"nctId":"NCT07350746","phase":"NA","title":"A Comparison of Outcome of Pulpotomy on Immature Permanent Molars Between Different Calcium Silicate-based Materials : a 12 Months Clinical Study","status":"ACTIVE_NOT_RECRUITING","sponsor":"Saint-Joseph University","startDate":"2025-10-01","conditions":"Pain, Lesions","enrollment":48},{"nctId":"NCT05763420","phase":"NA","title":"Clinical Efficacy of AH Plus Bioceramic Sealer","status":"ENROLLING_BY_INVITATION","sponsor":"Ministry of Health, Kuwait","startDate":"2023-08-07","conditions":"Root Canal Infection, Periapical Periodontitis, Periapical Diseases","enrollment":136},{"nctId":"NCT07290049","phase":"NA","title":"Postoperative Pain After Pulpotomy in Children Using Calcium Silicate Cements With and Without Laser Therapy","status":"RECRUITING","sponsor":"University of Fujairah","startDate":"2025-04-24","conditions":"Symptomatic Irreversible Pulpitis, Symptomatic Irreversible Pulpitis (SIP)","enrollment":46},{"nctId":"NCT07207382","phase":"PHASE3","title":"Clinical and Radiographic Evaluation of Three Biomimetic Materials in Pulp Therapy of Immature Young Permanent Teeth \"A Randomized Controlled Clinical Trial\"","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ain Shams University","startDate":"2024-02-20","conditions":"Pulpotomy of Young Permanent Molars","enrollment":69},{"nctId":"NCT07184151","phase":"NA","title":"Evaluation of Guided Endodontic Microsurgery and Two Different Retrograde Filling Materials","status":"COMPLETED","sponsor":"Suez Canal University","startDate":"2022-01-20","conditions":"Endodontic Re-treatment Failure","enrollment":24},{"nctId":"NCT06288477","phase":"NA","title":"Clinical and Radiographic Evaluation of Vital Pulpotomy Techniques in Primary Molars Using of Premixed Bioactive Bioceramic MTA (Neo-putty) as a Novel Pulpotomy Medication Versus Formocresol","status":"RECRUITING","sponsor":"October University for Modern Sciences and Arts","startDate":"2024-03-20","conditions":"Vital, Pulpotomy, Techniques","enrollment":44},{"nctId":"NCT06232941","phase":"NA","title":"Comparative Evaluation of Three Pulpotomy Agents for Permanent Mature Molars With Irreversible Pulpitis","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2024-04-01","conditions":"Vital Pulp Therapy","enrollment":36},{"nctId":"NCT04795830","phase":"PHASE4","title":"Bioactive Materials in Pulp Therapy of Primary Teeth","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2021-08-01","conditions":"Pulpitis, Pulp Disease, Dental","enrollment":60},{"nctId":"NCT05902936","phase":"NA","title":"Evaluation of Nano Bioactive Glass Combined With i-PRF Scaffold in Vital Pulp Treatments","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2023-03-01","conditions":"Pulpitis - Irreversible, Apical Periodontitis","enrollment":30},{"nctId":"NCT05597553","phase":"NA","title":"Evaluation of Premixed Verses Powder/Liquid Bioceramic MTA in Indirect Pulp Capping.","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2023-01-01","conditions":"Indirect Pulp Capping","enrollment":24},{"nctId":"NCT05496257","phase":"NA","title":"Calcium Hydroxide Versus Premixed Bioceramic Putty in Direct Pulp Capping of Primary Molars","status":"UNKNOWN","sponsor":"Minia University","startDate":"2021-11-02","conditions":"Direct Pulp Capping","enrollment":100},{"nctId":"NCT04482101","phase":"NA","title":"Single Visit Root Canal Treatment :Incidence of Postoperative Pain Using Two Different Sealers","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2020-09-01","conditions":"Postoperative Pain","enrollment":68}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Premixed Bioceramic material","genericName":"Premixed Bioceramic material","companyName":"Ain Shams University","companyId":"ain-shams-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Premixed bioceramic material provides a biocompatible scaffold that promotes bone regeneration and integration through osteoconductive and potentially osteoinductive properties. Used for Bone defect filling and regeneration in orthopedic and dental applications, Periodontal bone loss treatment.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}