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This combination mimics physiological insulin secretion patterns and is used to achieve glycemic control in patients with diabetes mellitus.","oneSentence":"Premix insulin is a combination of rapid-acting and intermediate-acting insulin that replaces or supplements the body's natural insulin to regulate blood glucose levels.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:02:23.814Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 1 diabetes mellitus"},{"name":"Type 2 diabetes mellitus"}]},"trialDetails":[{"nctId":"NCT05768191","phase":"PHASE4","title":"Comparative Efficacy of a Two Daily Mixed Insulin Injection Versus a Basal-bolus Scheme With Human Insulin","status":"COMPLETED","sponsor":"Université NAZI BONI","startDate":"2023-06-15","conditions":"Type 1 Diabetes","enrollment":22},{"nctId":"NCT05479591","phase":"","title":"A Research Study Looking at Blood Sugar Control in People With Type 2 Diabetes Previously Treated With Premix Insulin and Initiating Treatment With Insulin Degludec/Liraglutide (IDegLira) in Local Clinical Practice in Croatia","status":"WITHDRAWN","sponsor":"Novo Nordisk A/S","startDate":"2022-07-30","conditions":"Diabetes Mellitus, Type 2","enrollment":""},{"nctId":"NCT05578352","phase":"NA","title":"The Exploreration of the Management for the Positive IAA in Patients With Type 2 Diabetes After Premix Insulin Therapy","status":"UNKNOWN","sponsor":"Nanjing First Hospital, Nanjing Medical University","startDate":"2022-08-05","conditions":"Type 2 Diabetes Mellitus","enrollment":20},{"nctId":"NCT04656106","phase":"","title":"A Study Investigating the Clinical Parameters Associated With the Use of Ryzodeg® (Insulin Degludec/Insulin Aspart) in a Real-world Adult Population With Type 2 Diabetes in South Korea","status":"COMPLETED","sponsor":"Novo Nordisk A/S","startDate":"2021-04-27","conditions":"Diabetes Mellitus, Type 2","enrollment":200},{"nctId":"NCT02762578","phase":"PHASE3","title":"Comparing Efficacy and Safety of Insulin Degludec/Insulin Aspart and BIAsp 30 in Subjects With Type 2 Diabetes","status":"COMPLETED","sponsor":"Novo Nordisk A/S","startDate":"2016-05-03","conditions":"Diabetes, Diabetes Mellitus, Type 2","enrollment":543},{"nctId":"NCT01855243","phase":"NA","title":"Comparison on Efficacy and Safety of Three Inpatient Insulin Therapy in Type2 DM","status":"COMPLETED","sponsor":"Cairo University","startDate":"2010-03","conditions":"Diabetes Mellitus (DM)","enrollment":63},{"nctId":"NCT01009580","phase":"PHASE3","title":"Comparison of NN5401 With Biphasic Insulin Aspart 30 in Type 2 Diabetes","status":"COMPLETED","sponsor":"Novo Nordisk A/S","startDate":"2009-11-05","conditions":"Diabetes, Diabetes Mellitus, Type 2","enrollment":447},{"nctId":"NCT02467920","phase":"PHASE4","title":"Efficacy and Safety of Basal Insulin Glargine Combination With Exenatide Bid vs Aspart30 in T2DM","status":"COMPLETED","sponsor":"Huazhong University of Science and Technology","startDate":"2015-08","conditions":"Type 2 Diabetes Mellitus","enrollment":349},{"nctId":"NCT02219750","phase":"PHASE4","title":"Comparison of Premixed Insulin With Basal-plus Insulin in Type 2 Diabetes Patients","status":"COMPLETED","sponsor":"Mackay Memorial Hospital","startDate":"2013-08","conditions":"Diabetes","enrollment":181},{"nctId":"NCT03458715","phase":"PHASE4","title":"The Efficacy of Sodium-glucose Co-transporter 2 Inhibitor or Dipeptidyl Peptidase-4 Inhibitor in Type 2 Diabetes Patients With Premix Insulin","status":"UNKNOWN","sponsor":"Mackay Memorial Hospital","startDate":"2017-09-21","conditions":"Type2 Diabetes","enrollment":120},{"nctId":"NCT00775736","phase":"","title":"Observational Study Evaluating the Safety of NovoMix® in Type 2 Diabetes Patients Previously Treated With a Human Premix Insulin","status":"COMPLETED","sponsor":"Novo Nordisk A/S","startDate":"2008-10","conditions":"Diabetes, Diabetes Mellitus, Type 2","enrollment":611},{"nctId":"NCT01707160","phase":"PHASE1","title":"Pharmacokinetics and Pharmacodynamics of Biphasic Insulin Aspart 30 in Healthy Volunteers","status":"COMPLETED","sponsor":"Novo Nordisk A/S","startDate":"1995-11","conditions":"Diabetes, Healthy","enrollment":24},{"nctId":"NCT01234597","phase":"PHASE4","title":"Evaluation of the Prandial Treatment Adjustment Effect Via Continuous Glucose Monitoring on Type 2 Diabetes Mellitus (DM) Patients Uncontrolled With a Basal Insulin or Premix Once a Day","status":"COMPLETED","sponsor":"Sanofi","startDate":"2012-12","conditions":"Diabetes Mellitus, Type 2","enrollment":219},{"nctId":"NCT01536652","phase":"","title":"Prandial Orientated Biphasic Insulin Aspart 30 Therapy - 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Insulin premixes, including biphasic insulin aspart, work by lowering blood sugar levels, according to ChEMBL, which lists their mechanism of action as insulin receptor agonists.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}