{"id":"pregnyl-1-500-iu","safety":{"commonSideEffects":[{"rate":"1–10","effect":"Ovarian hyperstimulation syndrome (OHSS)"},{"rate":"5–15","effect":"Injection site reactions (pain, redness, swelling)"},{"rate":"5–10","effect":"Headache"},{"rate":"5–10","effect":"Abdominal pain or bloating"},{"rate":"3–8","effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"hCG binds to luteinizing hormone receptors on Leydig cells (in males) and theca cells (in females), triggering testosterone production in males and progesterone production in females. In females, it triggers the LH surge necessary for ovulation. In males, it stimulates spermatogenesis and testosterone synthesis.","oneSentence":"Pregnyl is human chorionic gonadotropin (hCG) that mimics luteinizing hormone to stimulate gonadal hormone production and ovulation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:02:29.963Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Female infertility (ovulation induction, final maturation of oocytes in assisted reproductive technology)"},{"name":"Male hypogonadism (testosterone deficiency)"},{"name":"Cryptorchidism (undescended testis)"}]},"trialDetails":[{"nctId":"NCT03019575","phase":"PHASE3","title":"Efficacy and Safety of Corifollitropin Alfa (MK-8962) in Combination With Human Chorionic Gonadotropin (hCG) in Adolescent Males With Hypogonadotropic Hypogonadism (HH) (MK-8962-043)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2017-02-02","conditions":"Hypogonadotropic Hypogonadism","enrollment":17},{"nctId":"NCT02330770","phase":"PHASE4","title":"Dual Trigger Versus GnRHa Trigger Combined With Luteal HCG Administration","status":"UNKNOWN","sponsor":"Mansoura University","startDate":"2016-06-06","conditions":"Infertility","enrollment":225},{"nctId":"NCT04606082","phase":"NA","title":"Human Chorionic Gonadotropin Versus Granulocyte Colony Stimulating Factor in Increasing Pregnancy Rate in ICSI","status":"UNKNOWN","sponsor":"Al-Azhar University","startDate":"2020-10-30","conditions":"Fertility Disorders","enrollment":200},{"nctId":"NCT04604054","phase":"NA","title":"The Effect of Granulocyte Colony Stimulating Factor Versus Human Chorionic Gonadotropin in Females With a History of RIF","status":"UNKNOWN","sponsor":"Al-Azhar University","startDate":"2020-10-30","conditions":"Fertility Disorders","enrollment":100},{"nctId":"NCT03461601","phase":"NA","title":"Uterine Flushing With Human Chorionic Gonadotrophin and Unexplained Infertility","status":"COMPLETED","sponsor":"Ahmed Walid Anwar Murad","startDate":"2014-06-01","conditions":"Unexplained Infertility","enrollment":210},{"nctId":"NCT02469805","phase":"PHASE3","title":"Stimulated Versus Un-stimulated Intrauterine Insemination Cycles in Couples With Mild Male Factor Infertility","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2015-06","conditions":"Subfertility","enrollment":450},{"nctId":"NCT02470169","phase":"PHASE3","title":"Stimulated Versus Un-stimulated Intrauterine Insemination Cycles in Women With Endometriosis","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2015-06","conditions":"Subfertility","enrollment":450},{"nctId":"NCT02461173","phase":"PHASE3","title":"Stimulated Intrauterine Insemination Cycles and Unstimulated Intrauterine Insemination Cycles in Couples With Unexplained Infertility","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2015-06","conditions":"Infertility","enrollment":450},{"nctId":"NCT01507376","phase":"PHASE3","title":"Comparing the Efficacy of Urinary and Recombinant Human Chorionic Gonadotropin (hCG) on Oocyte Maturity","status":"COMPLETED","sponsor":"Royan Institute","startDate":"2010-10","conditions":"In Vitro Fertilization","enrollment":180},{"nctId":"NCT01079949","phase":"PHASE2","title":"A Phase II Study to Assess the Efficacy and Safety of Luveris® (Lutropin Alfa) in Mid Follicular Phase for Controlled Ovarian Stimulation (COS) in Advanced Reproductive Age","status":"TERMINATED","sponsor":"Merck KGaA, Darmstadt, Germany","startDate":"2007-11","conditions":"Infertility, Ovulation Induction","enrollment":93}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Hcg"],"phase":"marketed","status":"active","brandName":"Pregnyl (1,500) IU","genericName":"Pregnyl (1,500) IU","companyName":"Mount Sinai Hospital, Canada","companyId":"mount-sinai-hospital-canada","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pregnyl is human chorionic gonadotropin (hCG) that mimics luteinizing hormone to stimulate gonadal hormone production and ovulation. Used for Female infertility (ovulation induction, final maturation of oocytes in assisted reproductive technology), Male hypogonadism (testosterone deficiency), Cryptorchidism (undescended testis).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}