{"id":"pregnenolone-succinate","rwe":[{"pmid":"10010","year":"1976","title":"Electron paramagnetic resonance spectra of mitochondrial and microsomal cytochrome P-450 from the rat adrenal.","finding":"","journal":"Biochimica et biophysica acta","studyType":"Clinical Study"}],"tags":[{"label":"pregnenolone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Sex hormone-binding globulin","category":"target"},{"label":"SHBG","category":"gene"},{"label":"SERPINA6","category":"gene"},{"label":"G6PD","category":"gene"},{"label":"Active","category":"status"}],"phase":"phase_3","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["pregnenolone succinate"],"offLabel":[],"synonyms":["pregnenolone succinate"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"target":"Corticosteroid-binding globulin, Glucose-6-phosphate 1-dehydrogenase, Sex hormone-binding globulin","targets":[{"gene":"SHBG","source":"DrugCentral","target":"Sex hormone-binding globulin","protein":"Sex hormone-binding globulin"},{"gene":"SERPINA6","source":"DrugCentral","target":"Corticosteroid-binding globulin","protein":"Corticosteroid-binding globulin"},{"gene":"G6PD","source":"DrugCentral","target":"Glucose-6-phosphate 1-dehydrogenase","protein":"Glucose-6-phosphate 1-dehydrogenase"}],"modality":"Small Molecule","drugClass":"pregnenolone","explanation":"Imagine sex hormone-binding globulin as a protein that carries sex hormones like estrogen and testosterone. Pregnenolone succinate binds to this protein, which can affect how much of these hormones are available to the body. This can potentially impact various bodily functions and processes.","oneSentence":"Pregnenolone succinate works by binding to sex hormone-binding globulin, potentially altering the levels of sex hormones in the body.","technicalDetail":"Pregnenolone succinate acts as a competitive inhibitor of sex hormone-binding globulin, thereby modulating the availability of sex hormones such as estradiol and testosterone."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2256","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=PREGNENOLONE SUCCINATE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:28:19.012477","biosimilars":[],"competitors":[{"drugName":"cortisone acetate","drugSlug":"cortisone-acetate","fdaApproval":"1950-06-13","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"estradiol","drugSlug":"estradiol","fdaApproval":"1975-07-23","patentExpiry":"Nov 21, 2032","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"estradiol cypionate","drugSlug":"estradiol-cypionate","fdaApproval":"1979-08-15","genericCount":2,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"estriol","drugSlug":"estriol","fdaApproval":"","relationship":"same-target"},{"drugName":"estrone","drugSlug":"estrone","fdaApproval":"1979-02-21","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"hydrocortisone","drugSlug":"hydrocortisone","fdaApproval":"1952-08-05","patentExpiry":"Nov 19, 2032","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"hydrocortisone acetate","drugSlug":"hydrocortisone-acetate","fdaApproval":"1951-12-21","genericCount":14,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"hydroxyprogesterone caproate","drugSlug":"hydroxyprogesterone-caproate","fdaApproval":"1975-10-03","genericCount":2,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"nandrolone decanoate","drugSlug":"nandrolone-decanoate","fdaApproval":"1962-10-05","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"prasterone","drugSlug":"prasterone","fdaApproval":"","patentExpiry":"Mar 19, 2031","patentStatus":"Patent protected","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"pregnenolone succinate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"cortisone-acetate","brandName":"cortisone acetate","genericName":"cortisone acetate","approvalYear":"1950","relationship":"same-target"},{"drugId":"estradiol","brandName":"estradiol","genericName":"estradiol","approvalYear":"1975","relationship":"same-target"},{"drugId":"estradiol-cypionate","brandName":"estradiol cypionate","genericName":"estradiol cypionate","approvalYear":"1979","relationship":"same-target"},{"drugId":"estriol","brandName":"estriol","genericName":"estriol","approvalYear":"","relationship":"same-target"},{"drugId":"estrone","brandName":"estrone","genericName":"estrone","approvalYear":"1979","relationship":"same-target"},{"drugId":"hydrocortisone","brandName":"hydrocortisone","genericName":"hydrocortisone","approvalYear":"1952","relationship":"same-target"},{"drugId":"hydrocortisone-acetate","brandName":"hydrocortisone acetate","genericName":"hydrocortisone acetate","approvalYear":"1951","relationship":"same-target"},{"drugId":"hydroxyprogesterone-caproate","brandName":"hydroxyprogesterone caproate","genericName":"hydroxyprogesterone caproate","approvalYear":"1975","relationship":"same-target"},{"drugId":"nandrolone-decanoate","brandName":"nandrolone decanoate","genericName":"nandrolone decanoate","approvalYear":"1962","relationship":"same-target"},{"drugId":"prasterone","brandName":"prasterone","genericName":"prasterone","approvalYear":"","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"MMSL":"NOCODE","NDDF":"004993","UNII":"6LN4W6JJK6","CHEBI":"CHEBI:16581","VANDF":"4032600","INN_ID":"4178","RXNORM":"114052","UMLSCUI":"C0771291","ChEMBL_ID":"CHEMBL2105373","KEGG_DRUG":"D00143","DRUGBANK_ID":"DB02789","PDB_CHEM_ID":" PLO","PUBCHEM_CID":"10070529","SNOMEDCT_US":"47350002","IUPHAR_LIGAND_ID":"2376","SECONDARY_CAS_RN":"145-13-1","MESH_DESCRIPTOR_UI":"D011284"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":1,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"1976 Oct 13","pmid":"10010","title":"Electron paramagnetic resonance spectra of mitochondrial and microsomal cytochrome P-450 from the rat adrenal.","journal":"Biochimica et biophysica acta"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"PREGNENOLONE SUCCINATE","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pregnenolone succinate is a small molecule drug in the pregnenolone class, targeting sex hormone-binding globulin. Its mechanism of action and clinical uses are not well-documented, and it is unclear if it is FDA-approved or commercially available. As a result, there is limited information available on its safety profile, pharmacokinetics, or generic status. Further research is needed to fully understand this compound. Its development history is also unclear.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}