{"id":"pregabalin-oxaliplatin","safety":{"commonSideEffects":[{"rate":"10-30%","effect":"Neuropathy"},{"rate":"10-20%","effect":"Nausea"},{"rate":"5-15%","effect":"Vomiting"},{"rate":"5-10%","effect":"Diarrhea"},{"rate":"5-10%","effect":"Fatigue"}]},"_chembl":{"chemblId":"CHEMBL1059","moleculeType":"Small molecule","molecularWeight":"159.23"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Pregabalin binds to the alpha2-delta subunit of voltage-gated calcium channels, reducing excitatory neurotransmitter release. Oxaliplatin works by forming platinum-DNA adducts, which interfere with DNA replication and transcription, leading to cell death.","oneSentence":"Pregabalin is a GABA receptor agonist, while oxaliplatin is a platinum-based DNA crosslinking agent.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:29:57.151Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Neuropathic pain"},{"name":"Colorectal cancer"}]},"trialDetails":[{"nctId":"NCT01450163","phase":"PHASE3","title":"Evaluate The Efficacy and Safety Of Pregabalin In Prevention, Reduction of Oxaliplatin-Induced Painful Neuropathy","status":"COMPLETED","sponsor":"University of Sao Paulo","startDate":"2011-08","conditions":"Pain, Neuropathic Pain, Polyneuropathy","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Pregabalin, Oxaliplatin","genericName":"Pregabalin, Oxaliplatin","companyName":"University of Sao Paulo","companyId":"university-of-sao-paulo","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pregabalin is a small molecule that modulates voltage-gated calcium channels, used to treat conditions such as pain, neuropathic pain, and polyneuropathy. Oxaliplatin is a chemotherapeutic agent that can induce painful neuropathy, for which Pregabalin has been studied as a potential preventative treatment.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}