{"id":"preemptive-analgesia-of-dexmedetomidine","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Sedation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dexmedetomidine binds to alpha-2 adrenergic receptors in the central nervous system, particularly in the spinal cord and brainstem, which inhibits the release of norepinephrine and reduces pain signal transmission. When used preemptively (before surgical stimulation), it prevents the establishment of central sensitization and reduces postoperative pain requirements. This mechanism provides both analgesic and sedative effects, making it useful in perioperative pain management.","oneSentence":"Dexmedetomidine is a selective alpha-2 adrenergic agonist that reduces pain perception and provides analgesia through central nervous system effects.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:02:27.292Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Preemptive analgesia to reduce postoperative pain"},{"name":"Perioperative sedation and analgesia"}]},"trialDetails":[{"nctId":"NCT06999460","phase":"NA","title":"Analgesic Effect of Infraspinatus-teres Minor Block for Pre-emptive Analgesia in Patients Undergoing Shoulder Surgeries.","status":"RECRUITING","sponsor":"Zagazig University","startDate":"2025-06-09","conditions":"Preemptive Analgesia","enrollment":60},{"nctId":"NCT06946277","phase":"PHASE4","title":"Assessing the Time-Course of Dexmedetomidine-Induced Analgesia Via EEG","status":"NOT_YET_RECRUITING","sponsor":"China International Neuroscience Institution","startDate":"2025-04-25","conditions":"Total Hip Arthroplasty (THA), Intrathecal Anesthesia, Hip Osteoarthritis","enrollment":20},{"nctId":"NCT06671327","phase":"PHASE4","title":"Preemptive Analgesia Of Dexmedetomidine Reduces Per-operation Pain","status":"NOT_YET_RECRUITING","sponsor":"China International Neuroscience Institution","startDate":"2025-04-03","conditions":"Pain Management, Noncardiac Surgery","enrollment":208},{"nctId":"NCT05837000","phase":"PHASE4","title":"Dexmedetomidine, Ketamine and Magnesium Sulphate in Caudal Block for Hypospadias Repair","status":"UNKNOWN","sponsor":"Kafrelsheikh University","startDate":"2023-05-15","conditions":"Preemptive Analgesia, Dexmedetomidine, Ketamine","enrollment":75},{"nctId":"NCT05577962","phase":"NA","title":"Opioid Free Anesthesia on the Quality of Early Recovery","status":"UNKNOWN","sponsor":"Beijing Friendship Hospital","startDate":"2023-02-01","conditions":"Opioid-free Anesthesia","enrollment":160},{"nctId":"NCT02122510","phase":"NA","title":"Transverse Abdominal Block for Analgesia in Casarean Section","status":"COMPLETED","sponsor":"Tanta University","startDate":"2013-03","conditions":"Analgesia Disorder","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Preemptive Analgesia Of Dexmedetomidine","genericName":"Preemptive Analgesia Of Dexmedetomidine","companyName":"China International Neuroscience Institution","companyId":"china-international-neuroscience-institution","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dexmedetomidine is a selective alpha-2 adrenergic agonist that reduces pain perception and provides analgesia through central nervous system effects. Used for Preemptive analgesia to reduce postoperative pain, Perioperative sedation and analgesia.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}