{"id":"prednisolone-valaciclovir","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Immunosuppression-related infections"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Insomnia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Prednisolone is a corticosteroid that decreases immune cell activity and inflammatory mediator production. Valaciclovir is a prodrug of acyclovir that inhibits herpes simplex virus and varicella-zoster virus DNA polymerase, preventing viral replication. The combination addresses both the inflammatory and infectious components of certain viral conditions.","oneSentence":"Prednisolone suppresses immune and inflammatory responses while valaciclovir inhibits viral DNA replication, together reducing inflammation and controlling herpes virus infection.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:02:15.844Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Herpes zoster (shingles) with inflammatory complications"},{"name":"Bell's palsy associated with herpes simplex virus"}]},"trialDetails":[{"nctId":"NCT07349680","phase":"PHASE3","title":"Ultrasound-Guided Thoracic Paravertebral Block With Steroid and Local Anesthetic for Acute Herpes Zoster: Effects on Pain Control and Prevention of Postherpetic Neuralgia","status":"COMPLETED","sponsor":"Assiut University","startDate":"2023-03-15","conditions":"Postherpetic Neuralgia","enrollment":100},{"nctId":"NCT06474416","phase":"PHASE1","title":"A Study of the Safety, Tolerability and Prelinminary Efficacy of BD111 in Herpes Simplex Virus Type I Stromal Keratitis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Shanghai BDgene Co., Ltd.","startDate":"2023-09-04","conditions":"Herpes Simplex Virus Type I Stromal Keratitis","enrollment":16},{"nctId":"NCT03626376","phase":"PHASE4","title":"Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis","status":"WITHDRAWN","sponsor":"NYU Langone Health","startDate":"2019-12-10","conditions":"Herpes Simplex Virus Keratitis","enrollment":""},{"nctId":"NCT00510263","phase":"PHASE4","title":"Scandinavian Bell's Palsy Study","status":"COMPLETED","sponsor":"Uppsala University Hospital","startDate":"2001-05","conditions":"Bell's Palsy","enrollment":839}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":12,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Prednisolone + valaciclovir","genericName":"Prednisolone + valaciclovir","companyName":"Uppsala University Hospital","companyId":"uppsala-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Prednisolone suppresses immune and inflammatory responses while valaciclovir inhibits viral DNA replication, together reducing inflammation and controlling herpes virus infection. Used for Herpes zoster (shingles) with inflammatory complications, Bell's palsy associated with herpes simplex virus.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}