{"id":"prednisolone-sulfobenzoate","rwe":[],"tags":[{"label":"Corticosteroid","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Antineoplastic Agents","category":"pharmacology"},{"label":"Antineoplastic Agents, Hormonal","category":"pharmacology"},{"label":"Glucocorticoids","category":"pharmacology"},{"label":"Hormones","category":"pharmacology"}],"phase":"unknown","safety":{"safetySignals":[{"llr":74.655,"date":"","count":29,"signal":"Hepatocellular injury","source":"DrugCentral FAERS","actionTaken":"Reported 29 times (LLR=75)"},{"llr":58.66,"date":"","count":13,"signal":"Fixed eruption","source":"DrugCentral FAERS","actionTaken":"Reported 13 times (LLR=59)"},{"llr":54.541,"date":"","count":24,"signal":"Cholestasis","source":"DrugCentral FAERS","actionTaken":"Reported 24 times (LLR=55)"},{"llr":53.622,"date":"","count":25,"signal":"Urinary retention","source":"DrugCentral FAERS","actionTaken":"Reported 25 times (LLR=54)"},{"llr":46.025,"date":"","count":8,"signal":"Microphthalmos","source":"DrugCentral FAERS","actionTaken":"Reported 8 times (LLR=46)"},{"llr":45.286,"date":"","count":11,"signal":"Retinal artery occlusion","source":"DrugCentral FAERS","actionTaken":"Reported 11 times (LLR=45)"},{"llr":43.423,"date":"","count":17,"signal":"Hepatic cytolysis","source":"DrugCentral FAERS","actionTaken":"Reported 17 times (LLR=43)"},{"llr":41.562,"date":"","count":6,"signal":"Congenital oesophageal anomaly","source":"DrugCentral FAERS","actionTaken":"Reported 6 times (LLR=42)"},{"llr":39.666,"date":"","count":18,"signal":"Head injury","source":"DrugCentral FAERS","actionTaken":"Reported 18 times (LLR=40)"},{"llr":38.988,"date":"","count":6,"signal":"Cystic lymphangioma","source":"DrugCentral FAERS","actionTaken":"Reported 6 times (LLR=39)"},{"llr":36.015,"date":"","count":18,"signal":"Pancreatitis acute","source":"DrugCentral FAERS","actionTaken":"Reported 18 times (LLR=36)"},{"llr":34.758,"date":"","count":11,"signal":"Coronavirus infection","source":"DrugCentral FAERS","actionTaken":"Reported 11 times (LLR=35)"}],"commonSideEffects":[{"effect":"Hepatocellular injury","drugRate":"LLR 75","severity":"common"},{"effect":"Fixed eruption","drugRate":"LLR 59","severity":"common"},{"effect":"Cholestasis","drugRate":"LLR 55","severity":"common"},{"effect":"Urinary retention","drugRate":"LLR 54","severity":"common"},{"effect":"Microphthalmos","drugRate":"LLR 46","severity":"common"},{"effect":"Retinal artery occlusion","drugRate":"LLR 45","severity":"common"},{"effect":"Hepatic cytolysis","drugRate":"LLR 43","severity":"common"},{"effect":"Congenital oesophageal anomaly","drugRate":"LLR 42","severity":"common"},{"effect":"Head injury","drugRate":"LLR 40","severity":"common"},{"effect":"Cystic lymphangioma","drugRate":"LLR 39","severity":"common"},{"effect":"Pancreatitis acute","drugRate":"LLR 36","severity":"common"},{"effect":"Coronavirus infection","drugRate":"LLR 35","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"prednisolone metazoate","offLabel":[],"synonyms":["prednisolone sulfobenzoate","prednisolone metasulfobenzoate","prednisolone metasulfobenzoate sodium","prednisolone sodium metasulfobenzoate","prednisolone metazoate","prednisolone sodium metazoate"],"timeline":[],"approvals":[],"brandName":"Prednisolone Metazoate","ecosystem":[],"mechanism":{"moaClass":"Corticosteroid Hormone Receptor Agonists","modality":"Small Molecule","drugClass":"Corticosteroid","explanation":"Imagine your body's immune system as a fire alarm. When there's an infection or injury, the alarm goes off, and your body sends in the firefighters (white blood cells) to fight the fire. Prednisolone Metazoate helps to turn down the volume on the fire alarm, reducing the number of firefighters sent to the scene and minimizing the damage.","oneSentence":"Prednisolone Metazoate works by binding to glucocorticoid receptors in the body, which then modulate the expression of genes involved in inflammation and immune responses.","technicalDetail":"Prednisolone Metazoate exerts its effects by binding to the glucocorticoid receptor (GR), a transcription factor that regulates the expression of genes involved in inflammation and immune responses. This binding leads to the recruitment of co-repressors, which then inhibit the transcription of pro-inflammatory genes, resulting in a decrease in the production of pro-inflammatory cytokines and mediators."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2250","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=prednisolone sulfobenzoate","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:25:06.339846","biosimilars":[],"competitors":[],"genericName":"prednisolone sulfobenzoate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"MMSL":"5347","NDDF":"002155","UNII":"SR3YX73FW2","CHEBI":"CHEBI:135823","VANDF":"4017988","INN_ID":"535","RXNORM":"268872","UMLSCUI":"C0889299","ChEMBL_ID":"CHEMBL2111103","KEGG_DRUG":"D08413","DRUGBANK_ID":"DB00860","PDB_CHEM_ID":" TUA","PUBCHEM_CID":"181625","SNOMEDCT_US":"116601002","SECONDARY_CAS_RN":"3694-41-5","MESH_DESCRIPTOR_UI":"D011239"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Immunology"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Prednisolone Metazoate, also known as prednisolone sulfobenzoate, is a corticosteroid small molecule. It is a derivative of prednisolone, a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties. However, due to the lack of available information, its target, FDA approval status, and commercial status are unknown. Prednisolone Metazoate is used to treat various conditions, but specific indications are not available. As a corticosteroid, it is essential to consider its potential side effects and interactions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":false,"score":2}}