{"id":"prednisolone-and-tobramycin","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular irritation or discomfort"},{"rate":null,"effect":"Transient blurred vision"},{"rate":null,"effect":"Steroid-induced elevated intraocular pressure"},{"rate":null,"effect":"Allergic conjunctivitis"}]},"_chembl":{"chemblId":"CHEMBL1201014","moleculeType":"Small molecule","molecularWeight":"484.39"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Prednisolone is a corticosteroid that reduces inflammation by suppressing immune responses and decreasing inflammatory mediator production. Tobramycin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis. Together, they address both infectious and inflammatory components of ocular disease.","oneSentence":"This combination uses prednisolone to suppress inflammation and tobramycin to provide topical antimicrobial coverage, typically for ocular infections or inflammatory conditions.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:29:56.827Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Ocular inflammation with bacterial infection risk"},{"name":"Post-operative ocular inflammation and infection prophylaxis"}]},"trialDetails":[{"nctId":"NCT01431326","phase":"","title":"Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care","status":"COMPLETED","sponsor":"Daniel Benjamin","startDate":"2011-11","conditions":"Adenovirus, Anesthesia, Anxiety","enrollment":3520},{"nctId":"NCT05164692","phase":"NA","title":"Effects of Nasal-spraying LiveSpo Navax in Treatment of Acute Respiratory Infections in Children","status":"COMPLETED","sponsor":"National Children's Hospital, Vietnam","startDate":"2020-08-29","conditions":"Acute Respiratory Tract Infections","enrollment":100},{"nctId":"NCT02717871","phase":"PHASE3","title":"Swiss PACK-CXL Multicenter Trial for the Treatment of Infectious Keratitis","status":"COMPLETED","sponsor":"University Hospital, Geneva","startDate":"2016-03","conditions":"Keratitis; Infectious Disease (Manifestation)","enrollment":35},{"nctId":"NCT00198523","phase":"PHASE3","title":"A Bioequivalence Study of Tobramycin and Prednisolone Acetate Compared to PredForte","status":"COMPLETED","sponsor":"Bausch & Lomb Incorporated","startDate":"2005-07","conditions":"Eye Infections, Postoperative Complications","enrollment":132}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":44,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Prednisolone and Tobramycin","genericName":"Prednisolone and Tobramycin","companyName":"Bausch & Lomb Incorporated","companyId":"bausch-lomb-incorporated","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination uses prednisolone to suppress inflammation and tobramycin to provide topical antimicrobial coverage, typically for ocular infections or inflammatory conditions. Used for Ocular inflammation with bacterial infection risk, Post-operative ocular inflammation and infection prophylaxis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}