{"id":"prednisolone-and-amoxicillin-clavulanate","safety":{"commonSideEffects":[{"rate":null,"effect":"Immunosuppression / increased infection risk"},{"rate":null,"effect":"Gastrointestinal upset (nausea, diarrhea)"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Insomnia / mood changes"},{"rate":null,"effect":"Allergic reaction (amoxicillin)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Prednisolone is a corticosteroid that reduces inflammation and suppresses immune function by inhibiting cytokine production and immune cell activation. Amoxicillin/clavulanate is a beta-lactam antibiotic combination where amoxicillin inhibits bacterial cell wall synthesis and clavulanate protects it from beta-lactamase degradation, extending spectrum to beta-lactamase-producing organisms.","oneSentence":"This combination uses prednisolone to suppress immune and inflammatory responses while amoxicillin/clavulanate provides broad-spectrum bacterial coverage with beta-lactamase inhibition.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:02:12.812Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammatory and infectious conditions requiring concurrent immunosuppression and broad-spectrum antibiotic coverage"}]},"trialDetails":[{"nctId":"NCT02281929","phase":"PHASE3","title":"Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolone","status":"COMPLETED","sponsor":"University Hospital, Lille","startDate":"2015-06-13","conditions":"Alcoholic Hepatitis, Alcoholic Liver Disease","enrollment":297},{"nctId":"NCT05999955","phase":"NA","title":"Safety and Efficacy of DSM 32444 Postbiotic in the Treatment of Acute Rhinosinusitis","status":"COMPLETED","sponsor":"Huro Biotech Joint Stock Company","startDate":"2022-12-29","conditions":"Rhinosinusitis, Rhinitis","enrollment":60},{"nctId":"NCT00456339","phase":"PHASE4","title":"Systemic Steroids Plus Antibiotics in Sleep Apnea Syndrome in Children","status":"TERMINATED","sponsor":"University of Chicago","startDate":"2006-07","conditions":"Obstructive Sleep Apnea Syndrome","enrollment":4},{"nctId":"NCT01205984","phase":"PHASE4","title":"Systemic Methylprednisolone in Chronic Rhinosinusitis","status":"COMPLETED","sponsor":"Ondokuz Mayıs University","startDate":"2007-07","conditions":"Chronic Rhinosinusitis, Children","enrollment":48}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":19,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Prednisolone and amoxicillin/clavulanate","genericName":"Prednisolone and amoxicillin/clavulanate","companyName":"University of Chicago","companyId":"university-of-chicago","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination uses prednisolone to suppress immune and inflammatory responses while amoxicillin/clavulanate provides broad-spectrum bacterial coverage with beta-lactamase inhibition. Used for Inflammatory and infectious conditions requiring concurrent immunosuppression and broad-spectrum antibiotic coverage.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}