{"id":"pre-emptive-mycophenolate","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Diarrhea"},{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Vomiting"},{"rate":"5-10%","effect":"Abdominal pain"},{"rate":"5-10%","effect":"Leukopenia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This action results in a decrease in the production of lymphocytes, which are a type of white blood cell involved in the immune response. By reducing the number of lymphocytes, mycophenolate helps to prevent the body from rejecting transplanted organs. Additionally, its immunosuppressive effects can also help to reduce inflammation and prevent autoimmune diseases.","oneSentence":"Mycophenolate works by inhibiting inosine monophosphate dehydrogenase, an enzyme crucial for the synthesis of guanosine nucleotides, thereby suppressing lymphocyte proliferation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:29:56.341Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of organ rejection in kidney transplant patients"},{"name":"Treatment of certain autoimmune diseases, such as lupus nephritis"}]},"trialDetails":[{"nctId":"NCT00966836","phase":"PHASE3","title":"Prevention of Transplant Atherosclerosis With Everolimus and Anti-cytomegalovirus Therapy","status":"UNKNOWN","sponsor":"University of Bologna","startDate":"2009-04","conditions":"Heart Transplantation, Cardiac Allograft Vasculopathy, Cytomegalovirus Infection","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":26,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Pre-emptive mycophenolate","genericName":"Pre-emptive mycophenolate","companyName":"University of Bologna","companyId":"university-of-bologna","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mycophenolate works by inhibiting inosine monophosphate dehydrogenase, an enzyme crucial for the synthesis of guanosine nucleotides, thereby suppressing lymphocyte proliferation. Used for Prevention of organ rejection in kidney transplant patients, Treatment of certain autoimmune diseases, such as lupus nephritis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}