{"id":"pre-and-probiotic-fortification","safety":{"commonSideEffects":[{"rate":null,"effect":"Bloating"},{"rate":null,"effect":"Flatulence"},{"rate":null,"effect":"Mild gastrointestinal discomfort"}]},"_chembl":{"chemblId":"CHEMBL6068346","moleculeType":"Vaccine component"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This intervention combines prebiotics (non-digestible food components that selectively feed beneficial bacteria) and probiotics (live beneficial microorganisms) to restore and maintain a healthy gut microbiome. By promoting the growth of beneficial bacteria and improving intestinal barrier function, the approach aims to enhance nutrient absorption, reduce pathogenic colonization, and modulate immune system activation.","oneSentence":"Pre- and probiotic fortification enhances gut microbiota composition and function to improve digestive health and systemic immune responses.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:29:53.991Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Malnutrition and micronutrient deficiency in resource-limited settings"},{"name":"Gastrointestinal health and immune function optimization"}]},"trialDetails":[{"nctId":"NCT00255385","phase":"PHASE3","title":"Efficacy of Bifidus DR10 and Oligo Saccharides / Micronutrient Fortification of Milk","status":"COMPLETED","sponsor":"Johns Hopkins Bloomberg School of Public Health","startDate":"2002-04","conditions":"Diarrhea, Pneumonia, Febrile Illness","enrollment":1200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Pre and Probiotic fortification","genericName":"Pre and Probiotic fortification","companyName":"Johns Hopkins Bloomberg School of Public Health","companyId":"johns-hopkins-bloomberg-school-of-public-health","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pre- and probiotic fortification enhances gut microbiota composition and function to improve digestive health and systemic immune responses. Used for Malnutrition and micronutrient deficiency in resource-limited settings, Gastrointestinal health and immune function optimization.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}