{"id":"prasugrel-oral-tablet","safety":{"commonSideEffects":[{"rate":"1-15","effect":"Bleeding (major and minor)"},{"rate":"2-4","effect":"Dyspnea"},{"rate":"1-3","effect":"Bradycardia"},{"rate":"1-2","effect":"Rash"}]},"_chembl":{"chemblId":"CHEMBL1201772","moleculeType":"Small molecule","molecularWeight":"373.45"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Prasugrel is a prodrug that is metabolized to an active thiol metabolite, which then binds irreversibly to the P2Y12 receptor on platelet surfaces. This prevents adenosine diphosphate (ADP)-induced platelet activation and aggregation. By blocking this key pathway in platelet function, prasugrel reduces the risk of thrombotic cardiovascular events.","oneSentence":"Prasugrel is a thienopyridine antiplatelet agent that irreversibly inhibits the P2Y12 adenosine diphosphate receptor on platelets, preventing platelet aggregation and thrombosis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:02:01.855Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute coronary syndrome (ACS) including unstable angina, non-ST elevation myocardial infarction (NSTEMI), and ST elevation myocardial infarction (STEMI) managed with percutaneous coronary intervention (PCI)"}]},"trialDetails":[{"nctId":"NCT03430661","phase":"PHASE1","title":"A Study to Investigate the Interaction Between ACT-246475 and Clopidogrel, Prasugrel, and Ticagrelor in Healthy Subjects","status":"COMPLETED","sponsor":"Viatris Innovation GmbH","startDate":"2018-01-24","conditions":"Healthy","enrollment":77},{"nctId":"NCT06400940","phase":"PHASE4","title":"Prospective, Post-registration, Interventional, Randomized, in Parallel Groups, Multicenter Eurasian Clinical Study of DERIVO®/DERIVO® Mini Aneurysm Embolization Device, Europe-Asia","status":"RECRUITING","sponsor":"Federal State Budgetary Institution, V. 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The GASTRIM Study.","status":"COMPLETED","sponsor":"University Hospital, Bordeaux","startDate":"2014-12-08","conditions":"Impairment of Gastric Emptying, Acute Phase of Myocardial Infarction","enrollment":23},{"nctId":"NCT03672097","phase":"PHASE4","title":"Prasugrel Switching Study in Patients With Acute Coronary Syndrome (ACS) Who Underwent Percutaneous Coronary Intervention (PCI)","status":"COMPLETED","sponsor":"Daiichi Sankyo Taiwan Ltd., a Daiichi Sankyo Company","startDate":"2018-10-16","conditions":"Acute Coronary Syndrome (ACS)","enrollment":204},{"nctId":"NCT03296540","phase":"PHASE4","title":"CRUSHed vs. Uncrushed Prasugrel in STEMI Patients Undergoing PCI","status":"COMPLETED","sponsor":"Maasstad Hospital","startDate":"2017-11-28","conditions":"Cardiovascular Diseases","enrollment":729},{"nctId":"NCT04445623","phase":"PHASE3","title":"Prasugrel in Severe COVID-19 Pneumonia","status":"UNKNOWN","sponsor":"Azienda Ospedaliera Universitaria Integrata 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Used for Acute coronary syndrome (ACS) including unstable angina, non-ST elevation myocardial infarction (NSTEMI), and ST elevation myocardial infarction (STEMI) managed with percutaneous coronary intervention (PCI).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}