{"id":"pranoprofen-eyedrops","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular irritation or stinging"},{"rate":null,"effect":"Conjunctival hyperemia"},{"rate":null,"effect":"Transient corneal erosion"},{"rate":null,"effect":"Photophobia"}]},"_chembl":{"chemblId":"CHEMBL367463","moleculeType":"Small molecule","molecularWeight":"255.27"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As an NSAID formulated as an ophthalmic solution, pranoprofen works by blocking COX-1 and COX-2 enzymes, thereby decreasing prostaglandin production in ocular tissues. This reduces inflammation, pain, and photophobia associated with various ocular conditions. The drug is applied topically to the eye where it exerts local anti-inflammatory effects.","oneSentence":"Pranoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes to reduce prostaglandin synthesis and inflammation in the eye.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:02:02.484Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postoperative inflammation and pain following ocular surgery"},{"name":"Allergic conjunctivitis"},{"name":"Seasonal allergic rhinoconjunctivitis"}]},"trialDetails":[{"nctId":"NCT07291089","phase":"PHASE4","title":"Iris Vascular Area Density-Based Preoperative Pain-Risk Screening and Intervention in Second-Eye Cataract Surgery","status":"COMPLETED","sponsor":"Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine","startDate":"2024-02-23","conditions":"Age Related Cataract, Pain Management During Cataract Surgery","enrollment":126},{"nctId":"NCT05771194","phase":"PHASE4","title":"Analysis of Postoperative Ocular Surface Changes and Intervention Effect After PPV in MGD Dry Eye Patients","status":"COMPLETED","sponsor":"Tianjin Medical University Eye Hospital","startDate":"2021-02-01","conditions":"Meibomian Gland Dysfunction of Unspecified Eye, Unspecified Eyelid","enrollment":40},{"nctId":"NCT03712670","phase":"NA","title":"Nutraceutical Support With Omega-3","status":"COMPLETED","sponsor":"Università degli Studi di Brescia","startDate":"2016-01-01","conditions":"Retinal Disease","enrollment":60},{"nctId":"NCT03355638","phase":"PHASE4","title":"Treatment of CNV With Aflibercept Combined With Pranoprofen Eye Drops or Nutraceutical Support With Omega-3","status":"COMPLETED","sponsor":"Università degli Studi di Brescia","startDate":"2016-01","conditions":"Macular Edema","enrollment":60},{"nctId":"NCT03013959","phase":"","title":"Observation on the Herpes Simplex Keratitis","status":"UNKNOWN","sponsor":"Peking Union Medical College","startDate":"2016-11","conditions":"Keratitis, Herpetic","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Pranoprofen Eyedrops","genericName":"Pranoprofen Eyedrops","companyName":"Università degli Studi di Brescia","companyId":"universit-degli-studi-di-brescia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pranoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes to reduce prostaglandin synthesis and inflammation in the eye. Used for Postoperative inflammation and pain following ocular surgery, Allergic conjunctivitis, Seasonal allergic rhinoconjunctivitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}