{"id":"pranoprofen-eye-drops","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular irritation or stinging"},{"rate":null,"effect":"Conjunctival hyperemia"},{"rate":null,"effect":"Transient blurred vision"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As an NSAID, pranoprofen blocks COX-1 and COX-2 enzymes, thereby decreasing production of inflammatory prostaglandins in ocular tissues. This reduces inflammation, pain, and swelling in the eye. When formulated as eye drops, it provides local anti-inflammatory and analgesic effects for various ocular conditions.","oneSentence":"Pranoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes to reduce prostaglandin synthesis and inflammation in the eye.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:02:05.810Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postoperative ocular inflammation and pain following cataract surgery"},{"name":"Allergic conjunctivitis"},{"name":"Ocular inflammation associated with seasonal allergies"}]},"trialDetails":[{"nctId":"NCT07291089","phase":"PHASE4","title":"Iris Vascular Area Density-Based Preoperative Pain-Risk Screening and Intervention in Second-Eye Cataract Surgery","status":"COMPLETED","sponsor":"Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine","startDate":"2024-02-23","conditions":"Age Related Cataract, Pain Management During Cataract Surgery","enrollment":126},{"nctId":"NCT05771194","phase":"PHASE4","title":"Analysis of Postoperative Ocular Surface Changes and Intervention Effect After PPV in MGD Dry Eye Patients","status":"COMPLETED","sponsor":"Tianjin Medical University Eye Hospital","startDate":"2021-02-01","conditions":"Meibomian Gland Dysfunction of Unspecified Eye, Unspecified Eyelid","enrollment":40},{"nctId":"NCT03712670","phase":"NA","title":"Nutraceutical Support With Omega-3","status":"COMPLETED","sponsor":"Università degli Studi di Brescia","startDate":"2016-01-01","conditions":"Retinal Disease","enrollment":60},{"nctId":"NCT03355638","phase":"PHASE4","title":"Treatment of CNV With Aflibercept Combined With Pranoprofen Eye Drops or Nutraceutical Support With Omega-3","status":"COMPLETED","sponsor":"Università degli Studi di Brescia","startDate":"2016-01","conditions":"Macular Edema","enrollment":60},{"nctId":"NCT03013959","phase":"","title":"Observation on the Herpes Simplex Keratitis","status":"UNKNOWN","sponsor":"Peking Union Medical College","startDate":"2016-11","conditions":"Keratitis, Herpetic","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":13,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Pranoprofen eye drops","genericName":"Pranoprofen eye drops","companyName":"Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine","companyId":"shanghai-general-hospital-shanghai-jiao-tong-university-school-of-medicine","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pranoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes to reduce prostaglandin synthesis and inflammation in the eye. Used for Postoperative ocular inflammation and pain following cataract surgery, Allergic conjunctivitis, Ocular inflammation associated with seasonal allergies.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}