{"id":"pramocaine","brandName":"pramocaine","genericName":"pramocaine","companyId":"unknown","companyName":"","phase":"unknown","status":"active","modality":"","aliases":[],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"Pramocaine is a small molecule with a modality of a topical anesthetic and antipruritic. It has been studied for various conditions including pruritis, focal seizure, muscle soreness, ichthyosis, and pruritus, and has been used as a treatment for uremic itch in adult hemodialysis patients.","enrichmentLevel":3,"visitCount":1,"mechanism":{"target":"Sigma non-opioid intracellular receptor 1, Sodium channel alpha subunits; brain (Types I, II, III), Membrane-associated progesterone receptor component 1"},"administration":{},"safety":{"boxedWarnings":[],"safetySignals":[],"drugInteractions":[],"commonSideEffects":[],"contraindications":["Abscess of intestine","Acute tuberculosis","Adrenal cortical hypofunction","Anastomosis of intestine","Anxiety","Atrophoderma","Benign prostatic hyperplasia","Chronic heart failure","Conduction disorder of the heart","Contact dermatitis","Denuded skin","Diabetes mellitus","Disorder of coronary artery","Diverticulitis of gastrointestinal tract","Fissure in skin","Fungal ear infection","Gastrointestinal fistula","Herpes simplex","Herpes zoster 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Soreness","completionDate":"2023-04-30"},{"nctId":"NCT06999902","phase":"Phase 2","title":"A Double-Blind, Randomized, Multicenter, Trial Evaluating the Efficacy and Safety of PRAX-628 in Adults With Focal Seizures (POWER1)","status":"RECRUITING","sponsor":"Praxis Precision Medicines","isPivotal":true,"enrollment":230,"indication":"Focal Seizure","completionDate":"2025-12-08"},{"nctId":"NCT03796052","phase":"NA","title":"A Single Center, Clinical Study to Determine the Safety and Efficacy of an Avena Sativa Skincare Regimen for Therapy-Related Pruritus and Xerosis in Cancer Patients","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer Inc. (J&JCI)","isPivotal":false,"enrollment":53,"indication":"Ichthyosis, Pruritus","completionDate":"2019-12-18"},{"nctId":"NCT00405288","phase":"N/A","title":"The Safety of Proctofoam-HC in the Third Trimester of Pregnancy","status":"COMPLETED","sponsor":"The Hospital for Sick Children","isPivotal":false,"enrollment":408,"indication":"Hemorrhoids, Pregnancy","completionDate":"2010-06"},{"nctId":"NCT00693654","phase":"Phase 4","title":"A Controlled Comparative Study of the Efficacy of SARNA Sensitive Lotion for Treatment of Uremic Pruritus in Adult Hemodialysis Patients","status":"COMPLETED","sponsor":"Wake Forest University","isPivotal":false,"enrollment":28,"indication":"Pruritis","completionDate":"2008-10"}],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":true,"score":2}}