{"id":"prajmalium","rwe":[],"tags":[{"label":"prajmalium","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C01BA08","category":"atc"},{"label":"Active","category":"status"},{"label":"Ventricular arrhythmia","category":"indication"},{"label":"Anti-Arrhythmia Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"prajmaline","offLabel":[],"synonyms":["prajmaline bitartrate","prajmaline","prajmalium","N4-Propylajmalinium","N-Propylajmalinium","N-Propylajmaline"],"timeline":[],"approvals":[],"brandName":"Prajmaline","ecosystem":[{"indication":"Ventricular arrhythmia","otherDrugs":[{"name":"bretylium","slug":"bretylium","company":"Intl Medication"},{"name":"disopyramide","slug":"disopyramide","company":"Gd Searle Llc"},{"name":"lidocaine","slug":"lidocaine","company":"Fresenius Kabi Usa"},{"name":"mexiletine","slug":"mexiletine","company":""}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"prajmalium","explanation":"Imagine your heart is like a city with many streets. Sodium channels are like traffic lights that control the flow of electrical signals through the heart. When these channels get stuck, it can cause abnormal heart rhythms. Prajmaline helps to fix these traffic lights, allowing the heart to beat normally.","oneSentence":"Prajmaline works by blocking sodium channels in the heart, which helps to regulate abnormal heart rhythms.","technicalDetail":"Prajmaline acts as a class I antiarrhythmic agent by blocking the sodium channels in the cardiac action potential, which helps to prolong the effective refractory period and reduce the frequency of ventricular arrhythmias."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2230","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=PRAJMALIUM","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=PRAJMALIUM","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:27:39.806887","biosimilars":[],"competitors":[{"drugName":"quinidine","drugSlug":"quinidine","fdaApproval":"1950-07-12","genericCount":35,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"procainamide","drugSlug":"procainamide","fdaApproval":"1950-06-02","genericCount":26,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"disopyramide","drugSlug":"disopyramide","fdaApproval":"1977-09-01","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"prajmalium","indications":{"approved":[{"name":"Ventricular arrhythmia","source":"DrugCentral","snomedId":44103008,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"quinidine","brandName":"quinidine","genericName":"quinidine","approvalYear":"1950","relationship":"same-class"},{"drugId":"procainamide","brandName":"procainamide","genericName":"procainamide","approvalYear":"1950","relationship":"same-class"},{"drugId":"disopyramide","brandName":"disopyramide","genericName":"disopyramide","approvalYear":"1977","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT02933437","phase":"PHASE2","title":"The Response To Ajmaline Provocation in Healthy Subjects","status":"UNKNOWN","sponsor":"St George's, University of London","startDate":"2017-10-22","conditions":["Brugada Syndrome","Sudden Death"],"enrollment":100,"completionDate":"2019-12"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"007115","UNII":"75934UD4GJ","CHEBI":"CHEBI:135560","RXNORM":"236896","UMLSCUI":"C0032899","ChEMBL_ID":"CHEMBL3833382","DRUGBANK_ID":"DB13555","PUBCHEM_CID":"76959818","MESH_DESCRIPTOR_UI":"D011219"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":58,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"C01BA08","allCodes":["C01BA08"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Prajmaline is a small molecule with the synonyms BITARTRATE DE PRAJMALIUM, BITARTRATO DE PRAJMALIO, GT-1012, NEO GILURYTHMAL, NEO-GILURYTMAL, and NPA-P. It has been studied in clinical trials for conditions such as Brugada Syndrome and Sudden Death, specifically in relation to its effects when used as the intervention Ajmaline.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}