{"id":"pqed-typhoid-conjugate-vaccine","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or erythema"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Myalgia"}]},"_chembl":{"chemblId":"CHEMBL2108822","moleculeType":"Vaccine component"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a conjugate vaccine that links typhoid polysaccharide antigens to a protein carrier, enhancing T-cell dependent B-cell responses and generating both antibody and cellular immunity. The conjugation strategy improves immunogenicity compared to unconjugated polysaccharide vaccines, particularly in younger populations, and provides protection against typhoid fever caused by Salmonella typhi.","oneSentence":"PQed Typhoid Conjugate Vaccine stimulates immune response against Salmonella typhi by presenting conjugated polysaccharide antigens to the adaptive immune system.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:29:46.435Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of typhoid fever caused by Salmonella typhi"}]},"trialDetails":[{"nctId":"NCT04051268","phase":"PHASE3","title":"Immunogenicity and Safety of Vi-DT (Diphtheria Toxoid) Typhoid Conjugate Vaccine (Phase III)","status":"COMPLETED","sponsor":"PT Bio Farma","startDate":"2020-03-02","conditions":"Safety Issues, Immunogenicity","enrollment":3071}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"PQed Typhoid Conjugate Vaccine","genericName":"PQed Typhoid Conjugate Vaccine","companyName":"PT Bio Farma","companyId":"pt-bio-farma","modality":"Biologic","firstApprovalDate":"","aiSummary":"PQed Typhoid Conjugate Vaccine stimulates immune response against Salmonella typhi by presenting conjugated polysaccharide antigens to the adaptive immune system. Used for Prevention of typhoid fever caused by Salmonella typhi.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}