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PPIs are prodrugs that require activation in the acidic environment of the stomach to exert their effect.","oneSentence":"PPIs inhibit the proton pump (H+/K+-ATPase) in gastric parietal cells to reduce gastric acid secretion.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:02:00.712Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Gastroesophageal reflux disease (GERD)"},{"name":"Peptic ulcer disease"},{"name":"Zollinger-Ellison syndrome"},{"name":"Prevention of NSAID-induced ulcers"}]},"trialDetails":[{"nctId":"NCT07137442","phase":"","title":"Distinguishing Tics and Functional Tics Using Clinical Neurophysiological Techniques","status":"RECRUITING","sponsor":"National Institute of Neurological Disorders and Stroke (NINDS)","startDate":"2026-04-01","conditions":"Tics, Functional Tics","enrollment":75},{"nctId":"NCT05556824","phase":"PHASE2","title":"Multi-Center Study of Panosyl-Isomaltooligosaccharides Adjunctive to PPI Therapy to Treat 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