{"id":"potassium-nitrate","rwe":[],"_fda":{"id":"c850c90a-b9bc-44b7-b30c-3f297f3ae164","set_id":"02f4cf0b-188c-4522-b759-ffe4a9d150e8","openfda":{"unii":["RU45X2JN0Z","8ZYQ1474W7"],"route":["DENTAL"],"spl_id":["c850c90a-b9bc-44b7-b30c-3f297f3ae164"],"brand_name":["Sodium Fluoride 5000 ppm Sensitive"],"spl_set_id":["02f4cf0b-188c-4522-b759-ffe4a9d150e8"],"package_ndc":["11527-704-42"],"product_ndc":["11527-704"],"generic_name":["SODIUM FLUORIDE1.1%, POTASSIUM NITRATE 5%"],"product_type":["HUMAN PRESCRIPTION DRUG"],"substance_name":["POTASSIUM NITRATE","SODIUM FLUORIDE"],"manufacturer_name":["Sheffield Pharmaceuticals LLC"],"is_original_packager":[true]},"version":"2","warnings":["WARNINGS: Not for systemic treatment- Do not Swallow. Keep out of the reach of children. Children under 12 years of age, consult a dentist or physician. Note: Sensitive teeth may indicate a serious problem that may need prompt care by a dentist. See your dentist if the problem persists or worsens. Do not use this product longer than 4 weeks unless recommended by a dentist or physician."],"pregnancy":["Pregnancy: Teratogenic Effects Pregnancy Category B. It has been shown that fluoride crosses the placenta of rats, but only 0.01% of the amount administered is incorporated in fetal tissue. Animal studies (rats, mice, rabbits) have shown that fluoride is not a teratogen. Maternal exposure to 12.2 mg fluoride/kg of body weight (rats) or 13.1 mg/kg of body weight (rabbits) did not affect the litter size or fetal weight and did not increase the frequency of skeletal or visceral malformations. There are no adequate and well-controlled studies in pregnant women. However, epidemiological studies conducted in areas with high levels of naturally fluoridated water showed no increase in birth defects. Heavy exposure to fluoride during in utero development may result in skeletal fluorosis, which becomes evident in childhood."],"overdosage":["OVERDOSAGE: Accidental ingestion of large amounts of fluoride may result in acute burning in the mouth and sore tongue. Nausea, vomitting, and diarrhea may occur soon after ingestion (within 30 minutes)and are accompanied by salivation, hematemesis, and epigastric cramping abdominal pain. These symptoms may persist for 24 hours. If less than 5 mg fluoride/kg body weight (i.e. less than 2.3 mg fluoride/lb body weight) have been ingested, give calcium (e.g.milk) orally to relieve gastrointestinal symptoms and observe for a few hours. If more than 5 mg fluoride/kg body weight (i.e. more than 2.3 mg fluoride/lb body weight) have been ingested, induce vomitting, give orally soluble calcium (e.g. milk, 5% calcium gluconate or calcium lactate solution) and immediately seek medical assistance. For accidental ingestion of more than 15 mg fluoride /kg of body weight (i.e. more than 6.9 mg fluoride/lb body weight), induce vomitting and admit immediately to a hospital facility. A treatment dose (a thin ribbon) of Sodium Fluoride 5000 ppm Sensitive contains approximately 2.5 mg fluoride. A 3.4 FLOZ (100 ml) tube contains approximately 575 mg fluoride."],"references":["REFERENCES: American Dental Association, Accepted Dental Therapeutics, Ed. 40, Chicago, ADA, 405-407(1984). H.R. Englander et al., JADA, 75, 638-644 (1967). H.R. Englander et al., JADA, 78, 783-787 (1969). H.R. Englander et al., JADA, 82, 354-358 (1971)."],"description":["DESCRIPTION: Self-topical neutral fluoride toothpaste containing 1.1% (w/w) sodium fluoride and 5% potassium nitrate."],"precautions":["PRECAUTIONS: General not for systemic treatment. DO NOT SWALLOW. Carcinogenesis, Mutagenesis, Impairment of Fertility: In a study conducted in rodents, no carcinogenesis was found in male and female mice and female rats treated with fluoride at dose levels ranging from 4.1 to 9.1 mg/kg of body weight. Equivocal evidence of carcinogenesis was reported in male rats treated with 2.5 and 4.1 mg/kg of body weight. In a second study, no carcinogenesis was observed in rats, males or females, treated with fluoride up to 11.3 mg/kg of body weight. Epidemiological data provide no credible evidence for an association between fluoride, either naturally occurring or added to drinking water, and risk of human cancer. Fluoride ion is not mutagenic in standard bacterial systems. It has been shown that fluoride ion has potential to induce chromosome aberrations in cultured human and rodent cells at doses much higher than those to which humans are exposed. In vivo data are conflicting. Some studies report chromosome damage in rodents, while other studies using similar protocols report negative results. Potential adverse reproductive effects of fluoride exposure in humans have not been adequately evaluated. Adverse effects on reproduction were reported for rats, mice, fox, and cattle exposed to 100 ppm or greater concentrations of fluoride in their diet or drinking water. Other studies conducted in rats demonstrated that lower concentrations of fluoride (5 mg/kg of body weight) did not result in impaired fertility and reproductive capabilities. Pregnancy: Teratogenic Effects Pregnancy Category B. It has been shown that fluoride crosses the placenta of rats, but only 0.01% of the amount administered is incorporated in fetal tissue. Animal studies (rats, mice, rabbits) have shown that fluoride is not a teratogen. Maternal exposure to 12.2 mg fluoride/kg of body weight (rats) or 13.1 mg/kg of body weight (rabbits) did not affect the litter size or fetal weight and did not increase the frequency of skeletal or visceral malformations. There are no adequate and well-controlled studies in pregnant women. However, epidemiological studies conducted in areas with high levels of naturally fluoridated water showed no increase in birth defects. Heavy exposure to fluoride during in utero development may result in skeletal fluorosis, which becomes evident in childhood. Nursing Mothers: It is not known if fluoride is excreted in human milk. However, many drugs are excreted in milk, and caution should be exercised when products containing fluoride are administered to a nursing woman. Reduced milk production was reported in farm-raised fox when the animals were fed a diet containing a high concentration of fluoride (98-137 mg/kg of body weight). No adverse effects on parturition, lactation, or offspring were seen in rats administered fluoride up to 5 mg/kg of body weight. Pediatric Use: Safety and effectiveness in pediatric patients below the age of 12 years have not been established. Please refer to the CONTRAINDICATIONS and WARNINGS sections."],"how_supplied":["HOW SUPPLIED: Mild Mint 3.4 floz. (100ml) net wt. tube NDC# 11527-704-42 STORAGE: Store at Controlled Room Temperature, 20-25°C (68-77°F)."],"pediatric_use":["Pediatric Use: Safety and effectiveness in pediatric patients below the age of 12 years have not been established. Please refer to the CONTRAINDICATIONS and WARNINGS sections."],"effective_time":"20200401","nursing_mothers":["Nursing Mothers: It is not known if fluoride is excreted in human milk. However, many drugs are excreted in milk, and caution should be exercised when products containing fluoride are administered to a nursing woman. Reduced milk production was reported in farm-raised fox when the animals were fed a diet containing a high concentration of fluoride (98-137 mg/kg of body weight). No adverse effects on parturition, lactation, or offspring were seen in rats administered fluoride up to 5 mg/kg of body weight."],"adverse_reactions":["ADVERSE REACTIONS: Allergic reactions and other idiosyncrasies have been rarely reported. To report SUSPECTED ADVERSE REACTIONS, contact Sheffield Pharmaceuticals, LLC. at 1-800-222-1087 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch."],"contraindications":["CONTRAINDICATIONS: Do not use in pediatric patients under age 12 years unless recommended by a dentist or physician."],"how_supplied_table":["<table width=\"75%\" cellspacing=\"0\" cellpadding=\"0\"> <tbody> <tr styleCode=\"Botrule First\"> <td styleCode=\"Lrule Rrule\" rowspan=\"2\" align=\"left\" valign=\"top\"/> <td styleCode=\"Rrule\" align=\"left\" valign=\"top\"> <content styleCode=\"bold\">HOW SUPPLIED:</content> </td> <td styleCode=\"Rrule\" align=\"left\" valign=\"top\"> <content styleCode=\"bold\">Mild Mint </content> </td> <td styleCode=\"Rrule\" align=\"left\" valign=\"top\"/> </tr> <tr> <td styleCode=\"Lrule Rrule\" align=\"left\" valign=\"top\">3.4 floz. (100ml) net wt. tube</td> <td styleCode=\"Rrule\" align=\"left\" valign=\"top\">NDC# 11527-704-42</td> <td styleCode=\"Rrule\" align=\"left\" valign=\"top\"/> </tr> </tbody> </table>"],"inactive_ingredient":["Inactive Ingredients: Blue 1, Carrageenan, Cocamidopropyl Betaine, Flavor, Hydrated Silica, Mica, PEG-12, Poloxamer 407, Sodium Hydroxide, Sodium Laurryl Sulfate, Sodium Saccharin, Sorbitol, Titanium Dioxide, Water (purified), Yellow 10"],"storage_and_handling":["STORAGE: Store at Controlled Room Temperature, 20-25°C (68-77°F)."],"clinical_pharmacology":["CLINICAL PHARMACOLOGY: Frequent topical applications to the teeth with preparations having a relatively high fluoride content increase tooth resistance to acid dissolution and enhance penetration of the fluoride ion into tooth enamel."],"indications_and_usage":["INDICATIONS AND USAGE: A dental caries preventive and sensitive toothpaste; for twice daily self-applied topical use,following by rinsing, helps reduce the painful sensitivity of the teeth to cold, heat, acid, sweets or contact in adults patients and children 12 years of age and older. It is well established that 1.1% sodium fluoride is safe and extraordinarily effective as a caries preventive when applied frequently with mouthpiece applicators. 1-4 Sodium Fluoride 5000 ppm Sensitive 1.1% sodium fluoride toothpaste with 5% potassium nitrate in a squeeze-tube is easily applied onto a toothbrush. This prescription toothpaste should be used twice daily in place of your regular toothpaste, unless otherwise instructed by your dental professional. May be used whether or not drinking water is fluoridated, since topical fluoride cannot produce fluorosis. (See WARNINGS for exception.)"],"spl_unclassified_section":["SODIUM FLUORIDE 5000 ppm Sensitive toothpaste Rx ONLY","Active Ingredients: Sodium Fluoride 1.1% (w/w) Potassium Nitrate 5%"],"dosage_and_administration":["DOSAGE AND ADMINISTRATION: Follow these instructions unless otherwise instructed by your dental professional: Adults and pediatric patients 12 years of age or older, apply at least a 1 inch strip of Sodium Fluoride 5000 ppm Sensitive onto a soft bristle toothbrush. Brush teeth thoroughly for at least 1 minute, expectorate, and rinse mouth thoroughly. Use twice daily, (morning and evening) or as recommended by dentist or physician. Make sure to brush all sensitive areas of the teeth. Children under 12 years of age:consultant a dentist or physician."],"spl_product_data_elements":["Sodium Fluoride 5000 ppm Sensitive Sodium Fluoride1.1%, Potassium Nitrate 5% SODIUM FLUORIDE FLUORIDE ION POTASSIUM NITRATE NITRATE ION FD&C BLUE NO. 1 CARRAGEENAN COCAMIDOPROPYL BETAINE HYDRATED SILICA MICA POLYETHYLENE GLYCOL 600 POLOXAMER 407 SODIUM HYDROXIDE SODIUM LAURYL SULFATE POTASSIUM SODIUM SACCHARATE SORBITOL TITANIUM DIOXIDE WATER D&C YELLOW NO. 10"],"package_label_principal_display_panel":["PRINCIPAL DISPLAY PANEL - 100ml Tube Wentworth NDC 11527-704-42 Sodium Fluoride 5000 ppm MILD MINT Sensitive 1.1% Sodium Fluoride, 5% Potassium Nitrate Prescription Strength toothpaste for Sensitive Teeth 3.4 FLOZ (100ml) Rx only Wentworth Sensitive Tube.jpg","PRINCIPAL DISPLAY PANEL - 100 ml Carton Wentworth NDC 11527-704-42 Sodium Fluoride 5000 ppm MILD MINT Sensitive 1.1% Sodium Fluoride, 5% Potassium Nitrate Prescription Strength toothpaste for Sensitive teeth 3.4 FLOZ (100ml) Rx only 544198-SH00145_Sensitve_Carton.jpg"],"carcinogenesis_and_mutagenesis_and_impairment_of_fertility":["Carcinogenesis, Mutagenesis, Impairment of Fertility: In a study conducted in rodents, no carcinogenesis was found in male and female mice and female rats treated with fluoride at dose levels ranging from 4.1 to 9.1 mg/kg of body weight. Equivocal evidence of carcinogenesis was reported in male rats treated with 2.5 and 4.1 mg/kg of body weight. In a second study, no carcinogenesis was observed in rats, males or females, treated with fluoride up to 11.3 mg/kg of body weight. Epidemiological data provide no credible evidence for an association between fluoride, either naturally occurring or added to drinking water, and risk of human cancer. Fluoride ion is not mutagenic in standard bacterial systems. It has been shown that fluoride ion has potential to induce chromosome aberrations in cultured human and rodent cells at doses much higher than those to which humans are exposed. In vivo data are conflicting. Some studies report chromosome damage in rodents, while other studies using similar protocols report negative results. Potential adverse reproductive effects of fluoride exposure in humans have not been adequately evaluated. Adverse effects on reproduction were reported for rats, mice, fox, and cattle exposed to 100 ppm or greater concentrations of fluoride in their diet or drinking water. Other studies conducted in rats demonstrated that lower concentrations of fluoride (5 mg/kg of body weight) did not result in impaired fertility and reproductive capabilities."]},"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Dental","category":"route"},{"label":"Gel","category":"form"},{"label":"Active","category":"status"},{"label":"Prevention of dental caries","category":"indication"},{"label":"Explosive Agents","category":"pharmacology"}],"phase":"marketed","safety":{"boxedWarnings":[],"safetySignals":[{"date":"","signal":"DRUG INEFFECTIVE","source":"FDA FAERS","actionTaken":"236 reports"},{"date":"","signal":"PRODUCT USE IN UNAPPROVED INDICATION","source":"FDA FAERS","actionTaken":"95 reports"},{"date":"","signal":"ORAL DISCOMFORT","source":"FDA FAERS","actionTaken":"94 reports"},{"date":"","signal":"HYPERAESTHESIA TEETH","source":"FDA FAERS","actionTaken":"85 reports"},{"date":"","signal":"FATIGUE","source":"FDA FAERS","actionTaken":"82 reports"},{"date":"","signal":"NAUSEA","source":"FDA FAERS","actionTaken":"81 reports"},{"date":"","signal":"CONDITION AGGRAVATED","source":"FDA FAERS","actionTaken":"75 reports"},{"date":"","signal":"DIARRHOEA","source":"FDA FAERS","actionTaken":"74 reports"},{"date":"","signal":"DRUG EFFECTIVE FOR UNAPPROVED INDICATION","source":"FDA FAERS","actionTaken":"72 reports"},{"date":"","signal":"PAIN","source":"FDA FAERS","actionTaken":"61 reports"}],"commonSideEffects":[{"effect":"Respiratory tract infection bacterial","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Respiratory tract infection viral","drugRate":"LLR 87","severity":"common","_validated":true},{"effect":"Cytokine release syndrome","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Fibrin D dimer increased","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Stoma site discharge","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Stoma site erythema","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"On and off phenomenon","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Fibroma","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Stoma site irritation","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Bradykinesia","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Freezing phenomenon","drugRate":"LLR 22","severity":"common","_validated":true},{"effect":"Tension","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Platelet count decreased","drugRate":"","severity":"common","_validated":false,"_confidence":0.3},{"effect":"Stoma site pain","drugRate":"","severity":"common","_validated":false,"_confidence":0.3}],"contraindications":["Dental fluorosis"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=POTASSIUM NITRATE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T01:06:37.084132+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T01:06:43.548554+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=POTASSIUM NITRATE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T01:06:43.872183+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T01:06:35.826178+00:00"},"indications.approved":{"url":"","method":"ai_extraction","source":"FDA Label + AI","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"fda_label","retrievedAt":"2026-04-20T01:07:04.466308+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T01:06:35.826209+00:00"},"safety.safetySignals":{"url":"https://api.fda.gov/drug/event.json","method":"api_direct","source":"FDA FAERS","rawText":"","confidence":1,"sourceType":"fda_faers","retrievedAt":"2026-04-20T01:06:45.828976+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1644029/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:06:45.012906+00:00"}},"allNames":"saltpeter","offLabel":[],"synonyms":["potassium nitrate","nitric acid potassium salt","saltpeter"],"timeline":[],"approvals":[{"date":"","orphan":false,"company":"","regulator":"FDA"}],"brandName":"Saltpeter","ecosystem":[{"indication":"Prevention of dental caries","otherDrugs":[{"name":"colecalciferol","slug":"colecalciferol","company":"Sandoz"},{"name":"ergocalciferol","slug":"ergocalciferol","company":"Sanofi Aventis Us"},{"name":"retinol","slug":"retinol","company":"Hospira"},{"name":"sodium fluoride","slug":"sodium-fluoride","company":"Colgate Palmolive"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","explanation":"","oneSentence":"","technicalDetail":"Saltpeter's mechanism of action involves the release of nitric oxide, which activates the enzyme nitric oxide synthase, leading to the production of cyclic guanosine monophosphate (cGMP) and subsequent relaxation of smooth muscle cells, reducing tooth sensitivity and bacterial growth."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4263","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=POTASSIUM%20NITRATE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=POTASSIUM NITRATE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:27:20.001163","_validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T01:07:04.644467+00:00","fieldsConflicting":13,"overallConfidence":0.8},"biosimilars":[],"competitors":[],"genericName":"potassium nitrate","indications":{"approved":[{"id":"potassium-nitrate-dental-caries-prevention","name":"Dental Caries Prevention","dosing":null,"approvals":[],"diseaseId":"","eligibility":"Adults and children 12 years of age and older","pivotalTrial":null,"restrictions":[],"patientPopulation":"Adults and children 12 years of age and older","diagnosticRequired":null,"brandNameForIndication":"Saltpeter"},{"id":"potassium-nitrate-sensitive-teeth-relief","name":"Sensitive Teeth Relief","dosing":null,"approvals":[],"diseaseId":"","eligibility":"Adults and children 12 years of age and older","pivotalTrial":null,"restrictions":[],"patientPopulation":"Adults and children 12 years of age and older","diagnosticRequired":null,"brandNameForIndication":"Saltpeter"}],"offLabel":[{"name":"Dental Plaque Prevention","source":"DrugCentral","drugName":"POTASSIUM NITRATE","evidenceCount":6,"evidenceLevel":"emerging"},{"name":"Gingivitis","source":"DrugCentral","drugName":"POTASSIUM NITRATE","evidenceCount":37,"evidenceLevel":"moderate"}],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT06956599","phase":"PHASE3","title":"Hypersensitivity Reduction Efficacy: 5% Potassium Nitrate Toothpaste Compared to Colgate Cavity Protection Toothpaste","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2025-05-10","conditions":["Dentin Hypersensitivity"],"enrollment":80,"completionDate":"2025-08-11"},{"nctId":"NCT07478640","phase":"PHASE3","title":"Bioadhesive Film of Acmella Oleracea (Jambu) in the Reduction of Post-bleaching Dental Sensitivity Caused by Bleaching With 35% Hydrogen Peroxide.","status":"COMPLETED","sponsor":"Universidade Federal do Para","startDate":"2024-04-01","conditions":["Tooth Sensitivity","Teeth Whitening"],"enrollment":72,"completionDate":"2026-03-02"},{"nctId":"NCT07016074","phase":"PHASE2","title":"Inorganic Nitrate (NaNO3) Prevention of Contrast-Associated Acute Kidney Injury","status":"RECRUITING","sponsor":"University of Michigan","startDate":"2025-06-30","conditions":["Kidney Injury, Acute"],"enrollment":100,"completionDate":"2026-07"},{"nctId":"NCT07419763","phase":"NA","title":"Intra Oral Appliance (IOA) Model Evaluating the Efficacy of Sensitive Toothpaste","status":"COMPLETED","sponsor":"Church & Dwight Company, Inc.","startDate":"2025-04-15","conditions":["Dental Caries"],"enrollment":30,"completionDate":"2025-06-10"},{"nctId":"NCT07215767","phase":"PHASE3","title":"Clinical Study to Investigate the Antihypersensitivity Efficacy of a Novel Dentifrice","status":"RECRUITING","sponsor":"HALEON","startDate":"2025-09-16","conditions":["Dentin Hypersensitivity"],"enrollment":850,"completionDate":"2026-08"},{"nctId":"NCT07297732","phase":"NA","title":"A Study to Investigate the Tooth Whitening and Dentin Hypersensitivity Effectiveness of Two Experimental Toothpastes","status":"RECRUITING","sponsor":"HALEON","startDate":"2025-12-15","conditions":["Dentin Hypersensitivity"],"enrollment":105,"completionDate":"2026-03"},{"nctId":"NCT06967818","phase":"NA","title":"Combined Use of Potassium Nitrate Gel and Diode Laser for Dentin Hypersensitivity","status":"COMPLETED","sponsor":"University of Pavia","startDate":"2025-07-15","conditions":["Dentin Hypersensitivity"],"enrollment":23,"completionDate":"2026-01-10"},{"nctId":"NCT07172425","phase":"NA","title":"Evaluation of Adding Nitrate Into Foods for Regulating Nitric Oxide Bioavailability in Healthy Individuals","status":"RECRUITING","sponsor":"Queen Mary University of London","startDate":"2025-10-15","conditions":["Healthy Volunteers","Nitric Oxide","Vascular Function"],"enrollment":30,"completionDate":"2027-02"},{"nctId":"NCT06949072","phase":"NA","title":"A Clinical Study to Assess an Experimental Dentifrice in an Experimental Model of Early Stage Caries","status":"COMPLETED","sponsor":"HALEON","startDate":"2025-04-28","conditions":["Dental Caries"],"enrollment":47,"completionDate":"2025-09-11"},{"nctId":"NCT05138575","phase":"PHASE2","title":"SGLT2i and KNO3 in HFpEF - The SAK HFpEF Trial","status":"RECRUITING","sponsor":"University of Pennsylvania","startDate":"2022-01-24","conditions":["Heart Failure With Preserved Ejection Fraction"],"enrollment":53,"completionDate":"2026-03-01"},{"nctId":"NCT07056855","phase":"NA","title":"Three Different Topically Applied Materials as Non-invasive Treatment of Sensitivity in Permanent Teeth With Molar Incisor Hypomineralization","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-07-10","conditions":["Dentine Hypersensitivity"],"enrollment":48,"completionDate":"2025-07-20"},{"nctId":"NCT07027566","phase":"PHASE1","title":"Effect of an Experimental Cannabidiol Gel on Tooth Sensitivity","status":"NOT_YET_RECRUITING","sponsor":"Universidade Federal do Para","startDate":"2025-07-25","conditions":["Dentin Sensitivity"],"enrollment":75,"completionDate":"2026-07"},{"nctId":"NCT04913805","phase":"PHASE2","title":"Matching Perfusion and Metabolic Activity in HFpEF","status":"RECRUITING","sponsor":"University of Pennsylvania","startDate":"2021-10-11","conditions":["Heart Failure With Preserved Ejection Fraction"],"enrollment":53,"completionDate":"2027-05-01"},{"nctId":"NCT06971783","phase":"NA","title":"Effect of an Experimental Gel Based on Acmella Oleracea Extract Associated or Not With Fluoride on Dentin Hypersensitivity","status":"COMPLETED","sponsor":"Universidade Federal do Para","startDate":"2024-08-20","conditions":["Dentin Desensitizers","Non-carious Cervical Lesions","Dentin Hypersensitivity"],"enrollment":100,"completionDate":"2025-03-20"},{"nctId":"NCT02797184","phase":"PHASE1,PHASE2","title":"Inorganic NItrate and EXercise Performance in Heart Failure (iNIX-HF): Dose Response","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2017-10-31","conditions":["Heart Failure"],"enrollment":42,"completionDate":"2021-12-15"},{"nctId":"NCT06872749","phase":"NA","title":"Effect of an Experimental Gel Containing Copaiba Oil-resin in the Control of Dentin Hypersensitivity","status":"COMPLETED","sponsor":"Universidade Federal do Para","startDate":"2024-09-20","conditions":["Pain","Dentin Sensitivity","Dentin Desensitizing Agents"],"enrollment":75,"completionDate":"2025-03-10"},{"nctId":"NCT06242444","phase":"NA","title":"An Erosion Study to Investigate the Efficacy of an Experimental Dentifrice to Remineralize Enamel","status":"COMPLETED","sponsor":"HALEON","startDate":"2024-02-26","conditions":["Tooth Erosion"],"enrollment":33,"completionDate":"2024-05-07"},{"nctId":"NCT06896565","phase":"NA","title":"Effect of Nano Hydroxy Apatite Varnish and Potassium Nitrate Gel on the MIH-affected Permanent Teeth","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-06-01","conditions":["Molar Incisor Hypomineralisation"],"enrollment":48,"completionDate":"2026-08-01"},{"nctId":"NCT06923904","phase":"NA","title":"Potassium Nitrate Gel and Diode Laser in the Treatment of Dentinal Hypersensitivity","status":"NOT_YET_RECRUITING","sponsor":"University of Pavia","startDate":"2025-04-15","conditions":["Dentistry","Desensitization"],"enrollment":12,"completionDate":"2025-10-30"},{"nctId":"NCT05562167","phase":"PHASE2","title":"The Inorganic Nitrate and eXercise Performance in Heart Failure (iNIX-HF)","status":"RECRUITING","sponsor":"Washington University School of Medicine","startDate":"2023-03-31","conditions":["Heart Failure"],"enrollment":75,"completionDate":"2027-07-31"},{"nctId":"NCT06394557","phase":"NA","title":"Evaluation of In-office Bleaching-induced Sensitivity With 2 or 7 Days Interval Between Sessions","status":"ACTIVE_NOT_RECRUITING","sponsor":"Universidade Federal Fluminense","startDate":"2023-08-14","conditions":["Tooth Sensitivity"],"enrollment":47,"completionDate":"2025-12"},{"nctId":"NCT06614764","phase":"NA","title":"Effect of Andiroba on Control of Post-whitening Tooth Sensitivity","status":"COMPLETED","sponsor":"Universidade Federal do Para","startDate":"2024-10-01","conditions":["Tooth Bleaching","Pain","Dentin Desensitizing Agents"],"enrollment":75,"completionDate":"2024-11-30"},{"nctId":"NCT06871709","phase":"NA","title":"Clinical and Radiographic Evaluation of Potassium Nitrate in Polycarboxylate Versus Mineral Trioxide Aggregate in Vital Pulpotomy in Primary Molars","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-05-30","conditions":["Vital Pulp Therapies","Pulpotomy","Pulp Disease, Dental","Pulpotomies Primary Teeth","Pulp Therapy"],"enrollment":50,"completionDate":"2026-12-30"},{"nctId":"NCT06627790","phase":"PHASE3","title":"Efficacy of a Potassium Nitrate Containing Herbal Mouthwash to a Potassium Oxalate Mouthwash in Dentinal Hypersensitivity","status":"RECRUITING","sponsor":"Dr. D. Y. Patil Dental College & Hospital","startDate":"2025-02-25","conditions":["Dentin Hypersensitivity"],"enrollment":40,"completionDate":"2025-05"},{"nctId":"NCT06502535","phase":"NA","title":"Inulin and Nitrate's Effects on Vascular Health and Gut Microbiome","status":"COMPLETED","sponsor":"University of Exeter","startDate":"2023-05-09","conditions":["Endothelial Dysfunction","High Blood Pressure","Gut Microbiota Dysbiosis and Nutrition"],"enrollment":22,"completionDate":"2024-07-31"},{"nctId":"NCT06746558","phase":"NA","title":"Potassium Nitrate Gel and Diode Laser for Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"University of Modena and Reggio Emilia","startDate":"2023-01-07","conditions":["Hypersensitivity Dentin"],"enrollment":12,"completionDate":"2023-10-31"},{"nctId":"NCT05810974","phase":"NA","title":"The Impact of Inorganic Nitrate-rich Beetroot Juice on Microvascular Blood Flow and Cognitive Function","status":"COMPLETED","sponsor":"University of Reading","startDate":"2023-03-14","conditions":["Post Menopausal"],"enrollment":20,"completionDate":"2023-08-07"},{"nctId":"NCT05243745","phase":"NA","title":"Exploratory Clinical Study to Investigate the Ability of an Experimental Combination Dentifrice to Protect Sensitive Teeth","status":"COMPLETED","sponsor":"HALEON","startDate":"2022-02-28","conditions":["Dentin Sensitivity"],"enrollment":120,"completionDate":"2022-10-03"},{"nctId":"NCT06216262","phase":"NA","title":"Evaluation of the Effectiveness of Home-Use Desensitizing Agents on Dentin Hypersensitivity","status":"COMPLETED","sponsor":"Çanakkale Onsekiz Mart University","startDate":"2024-03-01","conditions":["Dentin Sensitivity"],"enrollment":180,"completionDate":"2024-08-23"},{"nctId":"NCT03259165","phase":"PHASE2","title":"Nitroglycerin vs. Furosemide Using Lung Ultrasound Pilot Trial","status":"TERMINATED","sponsor":"Indiana University","startDate":"2017-12-14","conditions":["Heart Failure","Heart Failure Acute","Acute Cardiac Failure","Acute Cardiac Pulmonary Edema"],"enrollment":52,"completionDate":"2021-12-31"},{"nctId":"NCT06417580","phase":"PHASE2","title":"Effect of Pregabalin Gel in Controlling Cervical Dentin Hypersensitivity","status":"NOT_YET_RECRUITING","sponsor":"Jesuína Lamartine Nogueira Araújo","startDate":"2024-05-28","conditions":["Dentin Sensitivity"],"enrollment":18,"completionDate":"2024-09-28"},{"nctId":"NCT06066671","phase":"NA","title":"The Effect of an Experimental Gel Based on Copaiba Oil Resin in Reducing Post-bleaching Tooth Sensitivity","status":"COMPLETED","sponsor":"Universidade Federal do Para","startDate":"2024-01-10","conditions":["Tooth Bleaching Pain"],"enrollment":75,"completionDate":"2024-05-07"},{"nctId":"NCT06358911","phase":"PHASE4","title":"A Clinical Study for the Effect of 4th Generation Poly AmidoAmine Dendrimer on Post-Bleaching Hypersensitivity and Shade Stability","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2021-11-13","conditions":["Tooth Hypersensitivity"],"enrollment":60,"completionDate":"2023-09-10"},{"nctId":"NCT06358924","phase":"PHASE4","title":"Effect of Different Desensitizing Agents on Post-bleaching Hypersensitivity and Shade Stability","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2021-11-13","conditions":["Tooth Hypersensitivity"],"enrollment":48,"completionDate":"2023-09-20"},{"nctId":"NCT05459558","phase":"NA","title":"Clinical Study to Investigate the Tooth Stain Removal Efficacy of Two Experimental Toothpastes Compared to a Standard Toothpaste When Used Twice Daily for 8 Weeks","status":"COMPLETED","sponsor":"HALEON","startDate":"2022-09-15","conditions":["Oral Hygiene"],"enrollment":280,"completionDate":"2022-12-04"},{"nctId":"NCT04964063","phase":"NA","title":"A Real-World Evidence Study to Evaluate Oral Health Related Quality of Life Using an Anti-Sensitivity Toothpaste","status":"COMPLETED","sponsor":"HALEON","startDate":"2021-08-31","conditions":["Dentin Sensitivity"],"enrollment":655,"completionDate":"2022-05-13"},{"nctId":"NCT02351063","phase":"NA","title":"HF Assessment With BNP in the Home: Part II","status":"TERMINATED","sponsor":"Alere San Diego","startDate":"2014-04","conditions":["Heart Failure"],"enrollment":1,"completionDate":"2014-07"},{"nctId":"NCT06180707","phase":"PHASE3","title":"Pregabalin Gel in Reducing Post-operative Tooth Sensitivity Surgery Caused by Bleaching With 35% Hydrogen Peroxide","status":"UNKNOWN","sponsor":"Universidade Federal do Para","startDate":"2024-01-05","conditions":["Tooth Bleaching","Sensitivity, Tooth"],"enrollment":75,"completionDate":"2024-04-30"},{"nctId":"NCT02840799","phase":"PHASE2","title":"Effect of KNO3 Compared to KCl on Oxygen UpTake in Heart Failure With Preserved Ejection Fraction (KNO3CK OUT HFPEF)","status":"COMPLETED","sponsor":"University of Pennsylvania","startDate":"2016-08","conditions":["Heart Failure"],"enrollment":84,"completionDate":"2022-08"},{"nctId":"NCT05710341","phase":"NA","title":"Nitrate INFORMER Water Study","status":"COMPLETED","sponsor":"Edith Cowan University","startDate":"2023-02-08","conditions":["Health Risk Behaviors"],"enrollment":25,"completionDate":"2023-05-30"},{"nctId":"NCT04590040","phase":"NA","title":"Trial of Nano-hydroxyapatite-Containing Toothpastes for Relief of Dentin Hypersensitivity","status":"COMPLETED","sponsor":"The University of Texas Health Science Center at San Antonio","startDate":"2020-07-28","conditions":["Dentin Sensitivity"],"enrollment":192,"completionDate":"2023-03-01"},{"nctId":"NCT05392868","phase":"PHASE2","title":"Managing Dentine Hypersensitivity With Silver Diamine Fluoride on Older Adults","status":"UNKNOWN","sponsor":"The University of Hong Kong","startDate":"2023-02-01","conditions":["Dentine Hypersensitivity"],"enrollment":166,"completionDate":"2024-02-28"},{"nctId":"NCT03775902","phase":"NA","title":"Regulation of KATP Channels and Na+/K+ ATPase in Relation to Fatigue Development","status":"COMPLETED","sponsor":"University of Copenhagen","startDate":"2018-12-19","conditions":["Insulin Resistance"],"enrollment":16,"completionDate":"2020-01-01"},{"nctId":"NCT05912907","phase":"NA","title":"Potassium Nitrate in Polycarboxylate as a Direct Pulp Capping","status":"UNKNOWN","sponsor":"Minia University","startDate":"2022-06-01","conditions":["Pulp Disease, Dental"],"enrollment":126,"completionDate":"2024-07"},{"nctId":"NCT05853523","phase":"PHASE2","title":"The Desensitizing Treatment Effects of the Laser and Ozone on Dentin Hypersensitivity: In-vivo Comparison","status":"COMPLETED","sponsor":"University of L'Aquila","startDate":"2021-02-27","conditions":["Dentin Sensitivity"],"enrollment":44,"completionDate":"2022-08-27"},{"nctId":"NCT03627130","phase":"PHASE2","title":"The Use of Inorganic Nitrate for the Prevention of Contrast-induced Nephropathy","status":"COMPLETED","sponsor":"Barts & The London NHS Trust","startDate":"2018-11-29","conditions":["Contrast-induced Nephropathy","Acute Kidney Injury","Acute Coronary Syndrome"],"enrollment":640,"completionDate":"2022-05-30"},{"nctId":"NCT05290298","phase":"NA","title":"Nitrate-based Nutritional Formula for Oxygen Saturation and Patient-reported Outcomes in Covid-19","status":"COMPLETED","sponsor":"University of Novi Sad, Faculty of Sport and Physical Education","startDate":"2021-09-01","conditions":["COVID-19"],"enrollment":52,"completionDate":"2022-02-15"},{"nctId":"NCT02519738","phase":"PHASE3","title":"Granulation Tissue Treatment: Silver Nitrate vs Kenalog vs Washcloth Abrasion","status":"TERMINATED","sponsor":"University of Michigan","startDate":"2015-01-15","conditions":["Other Abnormal Granulation Tissue Nos"],"enrollment":52,"completionDate":"2018-11-13"},{"nctId":"NCT04700241","phase":"NA","title":"Nitrate and Brain Insulin-Sensitivity","status":"COMPLETED","sponsor":"Maastricht University Medical Center","startDate":"2021-01-21","conditions":["Nitrate","Brain Insulin-sensitivity","Vascular Function"],"enrollment":18,"completionDate":"2021-05-05"},{"nctId":"NCT04755400","phase":"NA","title":"The Effect of Orally Administrated Nitrate on Renal Parameters and Systemic Haemodynamics","status":"COMPLETED","sponsor":"Frank Mose","startDate":"2018-09-01","conditions":["Hypertension"],"enrollment":18,"completionDate":"2020-03-15"},{"nctId":"NCT04632121","phase":"","title":"Oral Nicorandil in ST Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention","status":"UNKNOWN","sponsor":"Ahmed Abdel Nasser Abdel Rady","startDate":"2021-04-01","conditions":["Nicorandil"],"enrollment":300,"completionDate":"2023-12-29"},{"nctId":"NCT02956070","phase":"NA","title":"Anti-inflammatory Steroids in the Prevention of Tooth Sensitivity","status":"COMPLETED","sponsor":"Universidade Federal Fluminense","startDate":"2015-10","conditions":["Inflammation"],"enrollment":70,"completionDate":"2016-05"},{"nctId":"NCT03965039","phase":"NA","title":"A Clinical Study to Assess the Effects of Various Dentifrice Technologies on Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"Procter and Gamble","startDate":"2019-07-08","conditions":["Dentin Hypersensitivity"],"enrollment":120,"completionDate":"2019-10-03"},{"nctId":"NCT03943095","phase":"PHASE2","title":"Study to Characterize the Efficacy of a Dual Active Dentifrice for the Relief of Dentin Hypersensitivity","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2019-05-13","conditions":["Dentin Hypersensitivity","Dentin Sensitivity"],"enrollment":123,"completionDate":"2019-08-28"},{"nctId":"NCT03523598","phase":"NA","title":"Potassium Nitrate and Post-bleaching Sensitivity","status":"COMPLETED","sponsor":"Universidade Federal de Sergipe","startDate":"2018-05-26","conditions":["Medicaments Substances in Therapeutic Use"],"enrollment":75,"completionDate":"2018-09-01"},{"nctId":"NCT03483051","phase":"PHASE2","title":"Targeting Pulsatile Load to Increase Exercise Capacity and Quality of Life After Aortic Valve Replacement for Severe Aortic Stenosis (PULSE AS)","status":"COMPLETED","sponsor":"University of Pennsylvania","startDate":"2018-05-01","conditions":["Aortic Valve Stenosis"],"enrollment":5,"completionDate":"2019-05-23"},{"nctId":"NCT04305483","phase":"NA","title":"Evaluation of the Color Change of the Laser and Chemical Vital Whitening Method in the Teeth","status":"COMPLETED","sponsor":"Yuzuncu Yil University","startDate":"2013-12-01","conditions":["Color; Change Teeth, Posteruptive"],"enrollment":40,"completionDate":"2014-03-13"},{"nctId":"NCT02936830","phase":"PHASE4","title":"Effectiveness of Nanohydroxyapetite Paste on Reducing Dentin Hypersensitivity","status":"COMPLETED","sponsor":"Riyadh Colleges of Dentistry and Pharmacy","startDate":"2016-10","conditions":["Dentin Hypersensitivity"],"enrollment":63,"completionDate":"2017-06"},{"nctId":"NCT04179994","phase":"NA","title":"Efficacy of Miswak Extract Toothpaste as Compared Potassium Nitrate in The Management of Dentinal Hypersensitivity","status":"UNKNOWN","sponsor":"Ministry of Health, Saudi Arabia","startDate":"2020-01-01","conditions":["Dentine Hypersensitivity"],"enrollment":96,"completionDate":"2020-07-25"},{"nctId":"NCT04156152","phase":"NA","title":"Effectiveness of the Use of Desensitizing Dentifrices Based on Nanocrystals of Hydroxyapatite / 5% Potassium Nitrate / 1450ppm Sodium Monofluorophosphate and Potassium Nitrate 5% / 1426ppm Sodium Floride in the Treatment of Dentine Hypersensitivity. Test Randomized Clinical","status":"UNKNOWN","sponsor":"Universidad del Desarrollo","startDate":"2020-04-10","conditions":["Hypersensitivity Dentin"],"enrollment":32,"completionDate":"2020-08-21"},{"nctId":"NCT04006470","phase":"","title":"Meta-analysis of Stannous Fluoride and the Effects on Enamel Erosion","status":"COMPLETED","sponsor":"Procter and Gamble","startDate":"2018-01-08","conditions":["Enamel Erosion"],"enrollment":172,"completionDate":"2018-11-30"},{"nctId":"NCT04005417","phase":"","title":"Meta-analysis of Stannous Fluoride Dentifrice and the Effects on Dentine Hypersensitivity","status":"COMPLETED","sponsor":"Procter and Gamble","startDate":"2018-01-08","conditions":["Dentine Hypersensitivity"],"enrollment":1036,"completionDate":"2018-11-30"},{"nctId":"NCT03362697","phase":"NA","title":"Lactobacillus Reuteri for Treatment of Uncomplicated UTI in Pregnant Women","status":"COMPLETED","sponsor":"Innovacion y Desarrollo de Estrategias en Salud","startDate":"2017-12-15","conditions":["Urinary Tract Infection in Pregnancy"],"enrollment":150,"completionDate":"2019-06-18"},{"nctId":"NCT03909789","phase":"NA","title":"Effect of Inorganic Nitrate Supplement on Blood Pressure","status":"COMPLETED","sponsor":"Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center","startDate":"2017-11-17","conditions":["Blood Pressure","Endothelial Dysfunction"],"enrollment":67,"completionDate":"2018-06-22"},{"nctId":"NCT02916615","phase":"NA","title":"Effects of Nitrate in Vegetables on Blood Pressure in Subjects With Prehypertension","status":"COMPLETED","sponsor":"Karolinska Institutet","startDate":"2016-01","conditions":["Hypertension","Cardiovascular Disease"],"enrollment":225,"completionDate":"2019-01-30"},{"nctId":"NCT03267511","phase":"PHASE2","title":"A Study to Investigate the Stain and Plaque Removal Capability of Two Experimental Potassium Nitrate Dentifrices","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2017-09-25","conditions":["Oral Hygiene"],"enrollment":123,"completionDate":"2017-12-02"},{"nctId":"NCT02918617","phase":"PHASE2","title":"Clinical Efficacy in Relieving Dentin Hypersensitivity of Nanohydroxyapatite-Containing Toothpastes and Cream","status":"COMPLETED","sponsor":"The University of Texas Health Science Center at San Antonio","startDate":"2015-05","conditions":["Dentin Sensitivity"],"enrollment":203,"completionDate":"2016-09"},{"nctId":"NCT03738514","phase":"PHASE2","title":"Comparison of Efficacy of 5% Fluorocalcium Phosphosilicate Dentifrice and Potassium Nitrate Dentifrice on Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"Government Dental College and Research Institute, Bangalore","startDate":"2017-12-22","conditions":["Dentinal Hypersensitivity"],"enrollment":120,"completionDate":"2018-02-22"},{"nctId":"NCT02949115","phase":"PHASE2","title":"Effects of Red Beetroot Juice on High-Fat Meal-Induced Endothelial Dysfunction and Cardiometabolic Disturbances","status":"UNKNOWN","sponsor":"Colorado State University","startDate":"2016-11","conditions":["Overweight","Obesity","Aging","Menopause"],"enrollment":15,"completionDate":"2019-06"},{"nctId":"NCT02226562","phase":"PHASE2","title":"Clinical Study Investigating the Efficacy of a Mouthwash in Providing Long Term Relief From Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2014-09-02","conditions":["Dentin Sensitivity"],"enrollment":191,"completionDate":"2014-12-05"},{"nctId":"NCT03637426","phase":"NA","title":"Effect of Nano-hydroxyapatite and LASER on Dentin Hypersensitivity","status":"COMPLETED","sponsor":"Universidade Federal do Para","startDate":"2018-01-08","conditions":["Dentin Sensitivity"],"enrollment":80,"completionDate":"2018-08-03"},{"nctId":"NCT03621163","phase":"NA","title":"Copmere Between Bleaching and Laminate Veneers","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2018-12-05","conditions":["Discoloration, Tooth"],"enrollment":1,"completionDate":"2019-12-20"},{"nctId":"NCT02941653","phase":"NA","title":"Potassium Oxalate and Potassium Nitrate and Post-bleaching Sensitivity","status":"COMPLETED","sponsor":"Universidade Federal de Sergipe","startDate":"2016-11","conditions":["Medicaments Substances in Therapeutic Use"],"enrollment":47,"completionDate":"2017-10"},{"nctId":"NCT03434782","phase":"PHASE1","title":"Effect of Laser and Potassium Nitrate Application on the Sensitivity Control in Bleached Teeth","status":"COMPLETED","sponsor":"Universidade Federal do Para","startDate":"2017-04-24","conditions":["Dentin Sensitivity"],"enrollment":50,"completionDate":"2018-01-15"},{"nctId":"NCT03323372","phase":"PHASE2","title":"Different Concentrations of Potassium Nitrate in In-office Tooth Bleaching Sensitivity","status":"COMPLETED","sponsor":"Universidade Federal do Amazonas","startDate":"2016-12-21","conditions":["Tooth Sensitivity"],"enrollment":56,"completionDate":"2017-05-20"},{"nctId":"NCT02256345","phase":"PHASE2","title":"Pharmacokinetics, Pharmacodynamics, and Impact of Inorganic Nitrate on Exercise in HFpEF","status":"COMPLETED","sponsor":"University of Pennsylvania","startDate":"2015-01","conditions":["Heart Failure","Diastolic Heart Failure"],"enrollment":12,"completionDate":"2016-06"},{"nctId":"NCT02613130","phase":"NA","title":"A Study to Evaluate Oral Malodor and Other Outcomes Following The Use of Two-Step Toothpaste Oral Hygiene","status":"COMPLETED","sponsor":"Procter and Gamble","startDate":"2015-11","conditions":["Oral Malodor"],"enrollment":60,"completionDate":"2015-12"},{"nctId":"NCT03237793","phase":"NA","title":"Treatment of Hypersensitivity Using Diode Laser and Desensitising Agent on Fluorosed and Non-fluorosed Teeth","status":"COMPLETED","sponsor":"Krishnadevaraya College of Dental Sciences & Hospital","startDate":"2014-07","conditions":["Fluorosis, Dental","Non-Fluoride Enamel Opacities","Dentin Sensitivity"],"enrollment":90,"completionDate":"2015-09"},{"nctId":"NCT02533466","phase":"NA","title":"In Vivo Investigation of Initial Stages of Enamel Erosion","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2015-10-01","conditions":["Tooth Erosion"],"enrollment":30,"completionDate":"2015-11-06"},{"nctId":"NCT03166748","phase":"NA","title":"Clinical and Radiographic Assessments of Potassium Nitrate in Polycarboxylate Versus Mineral Trioxide Aggregate as Pulpotomy Biomaterials in Immature Mandibular First Permanent Molars","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2017-06","conditions":["Pulpotomy of Immature Lower First Molar(Apexegenesis)"],"enrollment":50,"completionDate":"2018-08"},{"nctId":"NCT02770573","phase":"NA","title":"Use of Biomaterials as Desensitizer Agents","status":"UNKNOWN","sponsor":"Università degli Studi di Sassari","startDate":"2016-03","conditions":["Dentin Sensitivity"],"enrollment":90,"completionDate":"2017-12"},{"nctId":"NCT03039270","phase":"NA","title":"Evaluation of Sensitivity With and Without Sonic Activation of a Desensitizing Gel Before in Office Bleaching in Adults","status":"COMPLETED","sponsor":"Federal University of Amazonas","startDate":"2016-01-18","conditions":["Dentin Sensitivity","Tooth Bleaching"],"enrollment":31,"completionDate":"2016-04-15"},{"nctId":"NCT03019224","phase":"PHASE4","title":"Effects of Desensitizing Dentifrices on the Reduction of Pain Sensitivity Caused by In-office Dental Whitening","status":"COMPLETED","sponsor":"University of Campinas, Brazil","startDate":"2016-01","conditions":["Tooth Whitening","Sensitivity"],"enrollment":4,"completionDate":"2016-08"},{"nctId":"NCT00752089","phase":"PHASE2","title":"Experimental Dentifrice Remineralization/Fluoride Uptake in an in Situ Model","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2007-09","conditions":["Dental Erosion"],"enrollment":20,"completionDate":"2008-01"},{"nctId":"NCT02895321","phase":"PHASE4","title":"Nano-hydroxyapatite With Potassium Nitrate in the Therapy of the Dental Sensitivity","status":"COMPLETED","sponsor":"Università degli Studi di Sassari","startDate":"2016-03","conditions":["Dentin Sensitivity"],"enrollment":35,"completionDate":"2016-09"},{"nctId":"NCT02931734","phase":"NA","title":"Assessment of Different Protocols for Cervical Dentin Hypersensitivity Treatment","status":"COMPLETED","sponsor":"Federal University of Uberlandia","startDate":"2014-10","conditions":["Hypersensitivity Dentin","Dentin Sensitivity","Dentin Hypersensitivity","Dentine Hypersensitivity"],"enrollment":140,"completionDate":"2015-07"},{"nctId":"NCT02829879","phase":"PHASE3","title":"Effectiveness of Arginin and Potassium Nitrate Dentifrices in Dentin Hypersensitivity Therapy","status":"UNKNOWN","sponsor":"University of Chile","startDate":"2015-12","conditions":["Dentin Sensitivity"],"enrollment":50,"completionDate":""},{"nctId":"NCT01727258","phase":"NA","title":"A Test on a New Experimental Mouth Rinse for Relieving Tooth Sensitivity","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer and Personal Products Worldwide","startDate":"2012-12","conditions":["Dentin Sensitivity"],"enrollment":153,"completionDate":"2013-02"},{"nctId":"NCT01345292","phase":"NA","title":"A Study of the Relief of Tooth Sensitivity of an Experimental Mouthrinse Device","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer and Personal Products Worldwide","startDate":"2011-04","conditions":["Dentin Sensitivity"],"enrollment":226,"completionDate":"2011-05"},{"nctId":"NCT01587950","phase":"PHASE1","title":"The Effects of Potassium Nitrate in Reducing Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2009-02","conditions":["Dentinal Hypersensitivity","Dental Pain"],"enrollment":12,"completionDate":"2009-04"},{"nctId":"NCT01610089","phase":"NA","title":"Nitric Oxide Flux and Ureagenesis in Argininosuccinate Synthetase Deficiency (ASSD)(Citrullinemia I)","status":"COMPLETED","sponsor":"Baylor College of Medicine","startDate":"2012-12","conditions":["Citrullinemia"],"enrollment":6,"completionDate":"2013-09"},{"nctId":"NCT02162927","phase":"NA","title":"Dietary Nitrate Supplementation and Crossfit Athletes","status":"COMPLETED","sponsor":"Florida State University","startDate":"2014-08","conditions":["Performance"],"enrollment":12,"completionDate":"2014-11"},{"nctId":"NCT01115452","phase":"PHASE2","title":"Efficacy of Potassium Nitrate Solution in Reducing Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2009-09","conditions":["Dentine Hypersensitivity"],"enrollment":32,"completionDate":"2009-10"},{"nctId":"NCT01657903","phase":"NA","title":"Evaluation of Efficacy of Experimental Gel to Foam Dentifrices in Dental Erosion","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2011-11","conditions":["Dental Erosion","Acid Wear"],"enrollment":56,"completionDate":"2012-02"},{"nctId":"NCT01333930","phase":"NA","title":"Placebo Controlled Study for Characterisation of Immunological Effects and Safety of Active O2","status":"COMPLETED","sponsor":"Adelholzener Alpenquellen GmbH","startDate":"2012-01","conditions":["Healthy"],"enrollment":44,"completionDate":"2012-04"},{"nctId":"NCT01426360","phase":"NA","title":"Instant and Lasting Relief Effects of Strontium Chloride/Potassium Nitrate Dentifrice on Dentin Hypersensitivity","status":"COMPLETED","sponsor":"Sun Yat-sen University","startDate":"2011-09","conditions":["Dentine Hypersensitivity"],"enrollment":79,"completionDate":"2011-09"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"route":"Dental","formulation":"Gel","formulations":[{"form":"GEL","route":"DENTAL","productName":"Sensitive Tooth PasteMulti Action"},{"form":"GEL","route":"DENTAL","productName":"Sensitive Tooth PasteWhitening"},{"form":"GEL","route":"DENTAL","productName":"Sodium Fluoride and Potassium Nitrate"},{"form":"GEL, DENTIFRICE","route":"DENTAL","productName":"Alora Sensitivity"},{"form":"GEL, DENTIFRICE","route":"DENTAL","productName":"Alora Sensitivity Whitening"},{"form":"GEL, DENTIFRICE","route":"DENTAL","productName":"COLGATE SENSITIVE WHITENING FRESH MINT"},{"form":"GEL, DENTIFRICE","route":"DENTAL","productName":"Colgate Enamel Health Sensitivity Relief"},{"form":"GEL, DENTIFRICE","route":"DENTAL","productName":"Opalescence Sensitivity Relief Whitening"},{"form":"GEL, DENTIFRICE","route":"DENTAL","productName":"Aim SensitiveCavity Protection"},{"form":"GEL, DENTIFRICE","route":"DENTAL","productName":"HAPEE GUMTECT SENSITIVE 100"},{"form":"GEL, DENTIFRICE","route":"DENTAL","productName":"Kiss My FaceEnamel Extra"},{"form":"GEL, DENTIFRICE","route":"DENTAL","productName":"Kiss My FaceSensitive"},{"form":"GEL, DENTIFRICE","route":"DENTAL","productName":"PreviDent 5000 Enamel Protect"},{"form":"GEL, DENTIFRICE","route":"DENTAL","productName":"PreviDent 5000 Sensitive"},{"form":"GEL, DENTIFRICE","route":"DENTAL","productName":"Sodium Fluoride 5000 ppm Enamel Protect"}]},"crossReferences":{"NUI":"N0000145854","MMSL":"5334","NDDF":"000692","UNII":"RU45X2JN0Z","VUID":"4017466","CHEBI":"CHEBI:63043","VANDF":"4017466","RXNORM":"34316","UMLSCUI":"C0071772","chemblId":"CHEMBL1644029","ChEMBL_ID":"CHEMBL1644029","KEGG_DRUG":"D02051","DRUGBANK_ID":"DB11090","PUBCHEM_CID":"24434","SNOMEDCT_US":"419267005","MESH_SUPPLEMENTAL_RECORD_UI":"C023844"},"formularyStatus":[],"_enricherVersion":"v2","_offLabelChecked":true,"developmentCodes":[],"ownershipHistory":[],"publicationCount":1012,"therapeuticAreas":["Infectious Disease"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"withdrawn","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":""},{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"IL","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"SG","regulator":"HSA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AE","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"KR","regulator":"MFDS","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AU","regulator":"TGA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"GB","regulator":"MHRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T01:07:04.644467+00:00","fieldsConflicting":13,"overallConfidence":0.8},"verificationStatus":"verified","dataCompleteness":{"mechanism":false,"indications":true,"safety":true,"trials":true,"score":3}}