{"id":"postoperative-pain-management-with-acetaminophen","safety":{"commonSideEffects":[{"rate":null,"effect":"Hepatotoxicity (at overdose)"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Rash"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":{"chemblId":"CHEMBL1647","moleculeType":"Small molecule","molecularWeight":"327.29"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Acetaminophen works primarily through inhibition of cyclooxygenase (COX) enzymes in the brain and spinal cord, reducing the production of prostaglandins that mediate pain and fever signaling. Unlike NSAIDs, it has minimal peripheral anti-inflammatory effects. The exact mechanism remains incompletely understood, but central nervous system effects predominate, making it effective for mild to moderate pain without significant gastrointestinal or cardiovascular side effects at therapeutic doses.","oneSentence":"Acetaminophen reduces pain and fever by inhibiting prostaglandin synthesis in the central nervous system.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:01:58.111Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postoperative pain management"},{"name":"Fever reduction"},{"name":"Mild to moderate pain"}]},"trialDetails":[{"nctId":"NCT07094542","phase":"PHASE2","title":"Jaw Muscle Pain Post Wisdom Molar Surgery","status":"NOT_YET_RECRUITING","sponsor":"Rutgers, The State University of New Jersey","startDate":"2026-05","conditions":"Post Operative Pain, Impacted Third Molar Tooth, Muscle Pain","enrollment":80},{"nctId":"NCT07423650","phase":"PHASE4","title":"Continous Infusion of Nefopam for Patients Undergoing Pancreatoduodenectomy","status":"RECRUITING","sponsor":"Iuliu Hatieganu University of Medicine and Pharmacy","startDate":"2026-03","conditions":"Pancreatoduodenectomy, Pain Management, Opioid Analgesia","enrollment":93},{"nctId":"NCT07489001","phase":"","title":"Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery","status":"RECRUITING","sponsor":"Marmara University","startDate":"2025-12-09","conditions":"Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy, Lumbar Degenerative Spondylolisthesis","enrollment":75},{"nctId":"NCT06112548","phase":"NA","title":"The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral TKA","status":"COMPLETED","sponsor":"Damascus University","startDate":"2024-03-01","conditions":"Arthritis Knee, Pain, Arthroplasty Complications","enrollment":80},{"nctId":"NCT07458282","phase":"NA","title":"The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-03-10","conditions":"Laparoscopic Surgery, Liposomal Bupivacaine, Transversus Abdominis Plane Block","enrollment":318},{"nctId":"NCT07458295","phase":"NA","title":"The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery in Gynecologic Oncology","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-03-10","conditions":"Laparoscopic Surgery, Gynecologic Oncology Patient, Liposomal Bupivacaine","enrollment":110},{"nctId":"NCT07458256","phase":"NA","title":"The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Laparoscopic Surgery","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-03-10","conditions":"Laparoscopic Surgery, Liposomal Bupivacaine, Local Infiltration","enrollment":190},{"nctId":"NCT07463482","phase":"NA","title":"Preoperative High-Dose Oral Paracetamol for Postoperative Analgesia in Children Undergoing Tonsillectomy\"","status":"NOT_YET_RECRUITING","sponsor":"Thammasat University","startDate":"2026-03","conditions":"Post Operative Analgesia, Tonsillectomy With or Without Adenoidectomy","enrollment":54},{"nctId":"NCT07432711","phase":"NA","title":"The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Video-assisted Thoracoscopic Surgery","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-03-02","conditions":"Video-assisted Thoracoscopic Surgery (VATS), Pain Management, Liposomal Bupivacaine","enrollment":100},{"nctId":"NCT07154433","phase":"NA","title":"A Study on Reducing Opioid Use After Minimally Invasive Ankle Surgery","status":"RECRUITING","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2025-09-01","conditions":"Ankle (Ligaments); Instability (Old Injury), Ankle Sprain, Talus Osteochondral Defect","enrollment":110},{"nctId":"NCT07442539","phase":"NA","title":"The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Hemorrhoid Surgery","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-03-02","conditions":"Hemorrhoid Surgery, Liposome Bupivacaine, Pain Management","enrollment":156},{"nctId":"NCT07441902","phase":"NA","title":"The Efficacy and Safety of Liposomal Bupivacaine for Rhomboid Intercostal Nerve Block in Relieving Postoperative Pain After Video-assisted Thoracoscopic Surgery","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-03-02","conditions":"Video-assisted Thoracoscopic Surgery (VATS), Pain Management, Liposomal Bupivacaine","enrollment":134},{"nctId":"NCT07401134","phase":"PHASE4","title":"Improving Postoperative Recovery: A Study of Multimodal Perineal Analgesia Protocol (MPAP) After Vaginal Surgery","status":"RECRUITING","sponsor":"University of Miami","startDate":"2026-02-18","conditions":"Perineal Injury, Pain Vulva, Perineum; Injury","enrollment":70},{"nctId":"NCT07435493","phase":"NA","title":"Fentanyl Versus Opioid Free Multimodal Analgesia for Perioperative Pain Control in Children With Mild to Moderate Obstructive Sleep Apnea","status":"NOT_YET_RECRUITING","sponsor":"Ain Shams University","startDate":"2026-11-30","conditions":"Adenotonsillectomy, Obstructive Sleep Apnea (OSA), Fentanyl","enrollment":64},{"nctId":"NCT06878014","phase":"PHASE4","title":"Comparing the Safety and Effectiveness of Different Doses of Morphine Administered in Spinal Anethesia for Pain Relief After Hip Replacement Surgery","status":"RECRUITING","sponsor":"Medical University of Silesia","startDate":"2025-03-04","conditions":"Analgesics, Opioid, Anesthesia, Spinal, Total Hip Replacement","enrollment":120},{"nctId":"NCT05640674","phase":"PHASE4","title":"Post-operative Pain Management in Children With Supracondylar Humerus Fractures","status":"TERMINATED","sponsor":"Baylor College of Medicine","startDate":"2023-09-12","conditions":"Supracondylar Humerus Fracture","enrollment":29},{"nctId":"NCT05144828","phase":"PHASE4","title":"Efficacy of Intercostal CryoAnalgesia in Robotic Lung Resection","status":"COMPLETED","sponsor":"Medical College of Wisconsin","startDate":"2022-02-15","conditions":"Pain, Postoperative, Lung Diseases","enrollment":33},{"nctId":"NCT07368790","phase":"NA","title":"Elective Total Abdominal Hysterectomy With Preoperative Analgesia Intravenous Paracetamol Versus Placebo","status":"COMPLETED","sponsor":"Queen Savang Vadhana Memorial Hospital, Thailand","startDate":"2024-10-10","conditions":"Postoperative Pain","enrollment":40},{"nctId":"NCT07357376","phase":"PHASE3","title":"Evaluating Suzetrigine for Pain Control Following TKA","status":"NOT_YET_RECRUITING","sponsor":"AdventHealth","startDate":"2026-03-01","conditions":"Postoperative Pain Following Knee Arthroplasty","enrollment":210},{"nctId":"NCT07348627","phase":"PHASE3","title":"Opioid-Sparing Joint Replacement","status":"NOT_YET_RECRUITING","sponsor":"Emory University","startDate":"2026-02","conditions":"Pain Management, Opioid Consumption","enrollment":120},{"nctId":"NCT06309693","phase":"NA","title":"Postoperative Pain Management Following Robotic Assisted Sacrocolpopexy","status":"COMPLETED","sponsor":"University of Alabama at Birmingham","startDate":"2025-01-22","conditions":"Pelvic Organ Prolapse, Post Operative Pain","enrollment":70},{"nctId":"NCT07331441","phase":"NA","title":"External Oblique Intercostal Plane Block for Postoperative Analgesia After Major Upper Abdominal Surgery","status":"NOT_YET_RECRUITING","sponsor":"Jun Zhang","startDate":"2026-01-15","conditions":"Abdominal Surgery, Postoperative Pain","enrollment":78},{"nctId":"NCT06565546","phase":"NA","title":"CYP2D6 Genotype-guided Management of Opioid Analgesics in Patients Undergoing Elective Ventral Hernia Repairs","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Florida","startDate":"2025-01-29","conditions":"Ventral Hernia","enrollment":100},{"nctId":"NCT07320833","phase":"NA","title":"Ultrasound-Guided PASC Block vs Femoral-Sciatic Nerve Block for Postoperative Analgesia After Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2023-02-01","conditions":"Knee Osteoarthritis, Postoperative Pain, Total Knee Arthroplasty","enrollment":62},{"nctId":"NCT07310524","phase":"NA","title":"COMPARISON OF OPIOID-FREE AND OPIOID-BASED ANESTHESIA TECHNIQUES ON qNOX INDEX IN ABDOMINAL SURGERY UNDER GENERAL ANESTHESIA","status":"COMPLETED","sponsor":"Muhammad Rahman Efendi Nasution","startDate":"2025-09-08","conditions":"Opioid-free Anesthesia","enrollment":42},{"nctId":"NCT06298227","phase":"NA","title":"Erector Spinae Plane Block vs Quadratus Lumborum Block for Laparoscopic Nephrectomy","status":"RECRUITING","sponsor":"Istanbul Medipol University Hospital","startDate":"2024-03-11","conditions":"Kidney Diseases, Kidney Failure","enrollment":60},{"nctId":"NCT06942702","phase":"NA","title":"Efficacy of Genicular Block on Total Knee Arthroplasty Surgery","status":"NOT_YET_RECRUITING","sponsor":"Mersin University","startDate":"2025-12-20","conditions":"Total Knee Anthroplasty, Genicular Nerves Block","enrollment":44},{"nctId":"NCT07296770","phase":"PHASE3","title":"An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service","status":"NOT_YET_RECRUITING","sponsor":"University of California, San Francisco","startDate":"2026-05-01","conditions":"Postsurgical Pain Management, Postsurgical Pain, Chronic, Opioid Use After Surgery","enrollment":126},{"nctId":"NCT07200544","phase":"PHASE4","title":"Meloxicam in Mohs Micrographic Surgery","status":"RECRUITING","sponsor":"University of Oklahoma","startDate":"2025-10-15","conditions":"Postoperative Pain, Acute, Skin Cancer","enrollment":300},{"nctId":"NCT07279883","phase":"","title":"Length of Hospital Stay and Postoperative Analgesic Requirements After Introduction of a Specific Maxillary Nerve Block in Children Undergoing Cleft Palate Surgery","status":"RECRUITING","sponsor":"Karolinska Institutet","startDate":"2017-01-01","conditions":"Cleft Palate Children","enrollment":150},{"nctId":"NCT05279898","phase":"NA","title":"Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies","status":"COMPLETED","sponsor":"Beth Israel Deaconess Medical Center","startDate":"2023-02-28","conditions":"Postoperative Delirium, Hemodynamic Instability, Pain","enrollment":70},{"nctId":"NCT07235995","phase":"PHASE4","title":"Paracetamol and Mannitol Injection and Postoperative Delirium","status":"NOT_YET_RECRUITING","sponsor":"Xiangya Hospital of Central South University","startDate":"2025-12-01","conditions":"Postoperative Delirium, Elderly, Non Cardiac Surgery","enrollment":1092},{"nctId":"NCT05840406","phase":"NA","title":"Effect of a Transversus Abdominis Plane Block on Wound Healing, Stress, and Immune Response After a Cesarean Delivery","status":"COMPLETED","sponsor":"University Hospital Sestre Milosrdnice","startDate":"2024-09-03","conditions":"Postoperative Pain, Cesarean Section, Wound Heal","enrollment":105},{"nctId":"NCT03823534","phase":"PHASE3","title":"Post-Op Pain Control for Prophylactic Intramedullary Nailing.","status":"RECRUITING","sponsor":"St. Louis University","startDate":"2019-02-20","conditions":"Bone Metastases, Lymphoma, Multiple Myeloma","enrollment":60},{"nctId":"NCT03413371","phase":"NA","title":"Different Peribulbar Blocks With SPI-guided Anaesthesia for VRS (P&MSPIVRS)","status":"COMPLETED","sponsor":"Medical University of Silesia","startDate":"2018-04-26","conditions":"Vitreoretinal Surgeries, Postoperative Nausea and Vomiting, Postoperative Pain","enrollment":184},{"nctId":"NCT07134660","phase":"NA","title":"Thoracic Surgery Intercostal Block Trial With Liposomal vs. Hydrochloride Bupivacaine","status":"NOT_YET_RECRUITING","sponsor":"Shanghai Pulmonary Hospital, Shanghai, China","startDate":"2025-09-01","conditions":"Postoperative Pain, Acute, Lung Cancer","enrollment":210},{"nctId":"NCT00712712","phase":"PHASE2","title":"Morphine After Radiofrequency Ablation of Painful Bone Metastases in Patients With Cancer","status":"COMPLETED","sponsor":"Institut Bergonié","startDate":"2007-12-24","conditions":"Metastatic Cancer, Pain, Unspecified Adult Solid Tumor, Protocol Specific","enrollment":78},{"nctId":"NCT05231460","phase":"PHASE4","title":"Pain Management Study","status":"ENROLLING_BY_INVITATION","sponsor":"University of Arizona","startDate":"2022-02-18","conditions":"Pain, Postoperative","enrollment":244},{"nctId":"NCT05708521","phase":"PHASE4","title":"Personalization of Opioid Prescription Following Orthognathic Surgery","status":"ACTIVE_NOT_RECRUITING","sponsor":"Nova Scotia Health Authority","startDate":"2023-04-24","conditions":"Pain, Postoperative, Orthognathic Surgery, Opioid Use","enrollment":201},{"nctId":"NCT06935331","phase":"PHASE4","title":"Prospective Opioid-Free AIS Fusion","status":"NOT_YET_RECRUITING","sponsor":"OrthoCarolina Research Institute, Inc.","startDate":"2025-08-15","conditions":"Adolescent Idiopathic Scoliosis (AIS)","enrollment":58},{"nctId":"NCT06225466","phase":"PHASE4","title":"Muscle Relaxation for Pediatric Adenotonsillectomy","status":"COMPLETED","sponsor":"University of Texas Southwestern Medical Center","startDate":"2024-04-10","conditions":"Tonsillectomy","enrollment":172},{"nctId":"NCT07084753","phase":"NA","title":"Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy","status":"NOT_YET_RECRUITING","sponsor":"IVO JURISIC","startDate":"2025-07-30","conditions":"Obese Patients, Bariatric Surgical Pain, Bariatric Surgery (Sleeve Gastrectomy )","enrollment":36},{"nctId":"NCT05100017","phase":"NA","title":"Methocarbamol vs Oxybutynin for Management of Pain and Discomfort S/P Ureteroscopy Procedure","status":"RECRUITING","sponsor":"Northwestern University","startDate":"2021-09-30","conditions":"Kidney Calculi, Kidney Diseases, Nephrolithiasis","enrollment":126},{"nctId":"NCT06174363","phase":"NA","title":"Analgesic Efficacy of Maxigesic in Breast Cancer Surgery","status":"RECRUITING","sponsor":"Yonsei University","startDate":"2023-12-28","conditions":"Breast Cancer","enrollment":84},{"nctId":"NCT07011472","phase":"NA","title":"Post-Operative Analgesic Selection in Patients Planned for Third Molar Extraction After Undergoing Shared Decision Making Using 2- Versus 3-Option Decision-Aids","status":"RECRUITING","sponsor":"Rutgers, The State University of New Jersey","startDate":"2025-06-16","conditions":"Pain Management, Shared Decision Making","enrollment":100},{"nctId":"NCT07037888","phase":"PHASE4","title":"Efficacy of Ketorolac for Postoperative Pain Management in Hip Arthroscopy: A Prospective Double-Blinded Randomized Controlled Trial","status":"RECRUITING","sponsor":"Henry Ford Health System","startDate":"2023-12-13","conditions":"Femoracetabular Impingement, Hip Arthroscopy","enrollment":100},{"nctId":"NCT03992859","phase":"NA","title":"Continuous Serrates Plane Block in Axillary Dissection","status":"COMPLETED","sponsor":"Azienda USL Reggio Emilia - IRCCS","startDate":"2018-01-12","conditions":"Breast Cancer","enrollment":15},{"nctId":"NCT07017361","phase":"NA","title":"ERAS Program Implementation for MIPD","status":"NOT_YET_RECRUITING","sponsor":"Seoul National University Hospital","startDate":"2025-07-15","conditions":"Pancreaticoduodenectomy, ERAS, Minimally Invasive Surgery","enrollment":140},{"nctId":"NCT07002788","phase":"NA","title":"Comparison Paravertebral and Serratus Anterior Plane Block in Video-assisted Thoracoscopic Surgery.","status":"ACTIVE_NOT_RECRUITING","sponsor":"Hacettepe University","startDate":"2024-12-01","conditions":"Lung Cancer (NSCLC), Lung Adenocarcinoma, Video Assisted Thoracic Surgery (VATS)","enrollment":122},{"nctId":"NCT05287217","phase":"NA","title":"Post-operative Pain Control With Acetaminophen and Ibuprofen After Functional Endoscopic Sinus Surgery","status":"TERMINATED","sponsor":"University of Illinois at Chicago","startDate":"2022-07-29","conditions":"Chronic Rhinosinusitis (Diagnosis)","enrollment":60},{"nctId":"NCT06967363","phase":"","title":"Multimodal Imaging and Biospecimen Collection for Low Back Pain (LBPB)","status":"NOT_YET_RECRUITING","sponsor":"Peking University Third Hospital","startDate":"2025-05-15","conditions":"Chronic Low Back Pain (CLBP), Acute Low Back Pain, Low Back Pain","enrollment":360},{"nctId":"NCT06683911","phase":"","title":"Opioids Continue to Play a Primary Role in the Management of Perioperative Pain Due to Opioid-Free Anesthesia in Open Heart Surgery.","status":"COMPLETED","sponsor":"Ankara City Hospital Bilkent","startDate":"2024-04-03","conditions":"Undergoing Open-Heart Surgery","enrollment":98},{"nctId":"NCT06948513","phase":"PHASE3","title":"Effect of Over-the-counter Analgesics on Postoperative Pain","status":"COMPLETED","sponsor":"Zitelli & Brodland Skin Cancer Center","startDate":"2022-12-22","conditions":"Pain Management","enrollment":200},{"nctId":"NCT02202369","phase":"PHASE4","title":"Multimodal Analgesia vs. Routine Care Pain Management for Lumbar Spine Fusion Surgery: A Prospective Randomized Study","status":"SUSPENDED","sponsor":"OrthoCarolina Research Institute, Inc.","startDate":"2015-06-25","conditions":"Single Level Lumbar Decompression and Fusion Spine Surgery","enrollment":50},{"nctId":"NCT03020875","phase":"PHASE4","title":"IV vs Oral Acetaminophen in Spine Fusion Perioperative Care","status":"ENROLLING_BY_INVITATION","sponsor":"Hospital for Special Surgery, New York","startDate":"2017-01","conditions":"Multimodal Analgesic Approach","enrollment":166},{"nctId":"NCT06653465","phase":"PHASE2, PHASE3","title":"Intravenous Acetaminophen for Postoperative Delirium in Older Patients Recovering From Major Noncardiac Surgery","status":"NOT_YET_RECRUITING","sponsor":"RenJi Hospital","startDate":"2025-06","conditions":"Delirium in Old Age","enrollment":1930},{"nctId":"NCT05050409","phase":"NA","title":"SMART Embedded Intervention for Military Postsurgical Engagement Readiness","status":"RECRUITING","sponsor":"University of Utah","startDate":"2022-05-01","conditions":"Knee Pain Chronic","enrollment":500},{"nctId":"NCT06570577","phase":"NA","title":"Opioid Sparing Effect of an ISP Nerve Block on Post-Op Pain Control in Posterior Cervical Spine Surgery","status":"RECRUITING","sponsor":"Stony Brook University","startDate":"2025-02-21","conditions":"Pain, Postoperative","enrollment":60},{"nctId":"NCT06340932","phase":"","title":"Impact of Opioid Avoidance Protocol for ACL Reconstruction","status":"COMPLETED","sponsor":"Matthew Varacallo","startDate":"2024-04-27","conditions":"ACL Tear, Post Operative Pain","enrollment":32},{"nctId":"NCT04761302","phase":"PHASE4","title":"Postoperative Pain Management in Patients Undergoing Intramedullary Nail Fixation After Tibia and Femoral Fractures","status":"COMPLETED","sponsor":"University of Puerto Rico","startDate":"2021-04-18","conditions":"Femur Fracture, Tibial Fractures","enrollment":167},{"nctId":"NCT06839716","phase":"NA","title":"Comparison of Ropivacaine-Poloxamer 407 Hydrogel and TAP Block for Postoperative Pain Management in Laparoscopic/Robotic Gastrectomy","status":"RECRUITING","sponsor":"Gangnam Severance Hospital","startDate":"2025-02-01","conditions":"Gastric Cancer","enrollment":134},{"nctId":"NCT03987022","phase":"PHASE4","title":"ICE-T Pain Regimen for Total Laparoscopic Hysterectomy","status":"COMPLETED","sponsor":"MetroHealth Medical Center","startDate":"2019-08-01","conditions":"Opioid Substitution Treatment","enrollment":66},{"nctId":"NCT04491617","phase":"NA","title":"STandard Versus No Opioid Prescription After Prolapse and Anti-INcontinence Surgery Trial","status":"COMPLETED","sponsor":"The Cleveland Clinic","startDate":"2020-08-27","conditions":"Postoperative Pain, Opioid Use, Prolapse; Female","enrollment":129},{"nctId":"NCT06507345","phase":"NA","title":"Postoperative Analgesia Intervention With Non-opioid Alternatives (PAIN-Alt) Trial - Breast Surgery","status":"RECRUITING","sponsor":"McGill University Health Centre/Research Institute of the McGill University Health Centre","startDate":"2024-11-26","conditions":"Post Operative Pain, Opioid Analgesic Adverse Reaction, Surgery","enrollment":540},{"nctId":"NCT06750627","phase":"PHASE4","title":"Efficacy of Continuous Erector Spinae Plane Block to Reduce Postoperative Pain in Patients Undergoing Unilateral Thoracotomy","status":"NOT_YET_RECRUITING","sponsor":"Udayana University","startDate":"2025-01-01","conditions":"Continuous Erector Spinae Plane Block, Unilateral Thoracotomy","enrollment":30},{"nctId":"NCT03711734","phase":"NA","title":"Acupuncture ACL (Anterior Cruciate Ligament)","status":"COMPLETED","sponsor":"Hospital for Special Surgery, New York","startDate":"2018-11-01","conditions":"ACL, ACL Injury, Anterior Cruciate Ligament Injury","enrollment":40},{"nctId":"NCT03084536","phase":"PHASE2","title":"PECS Block vs. Multimodal Analgesia for Prevention of Persistent Postoperative Pain in Breast Surgery","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2017-06-07","conditions":"Breast Cancer, Breast Cancer Female, Cancer of Breast","enrollment":134},{"nctId":"NCT02588027","phase":"NA","title":"Effect of Ibuprofen on Postoperative Opiate Medication Use and Shoulder Functional Outcomes","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2015-10","conditions":"Rotator Cuff Tear Arthropathy","enrollment":110},{"nctId":"NCT06721819","phase":"PHASE3","title":"The SCOPE Trial: Sleep, Cognition, and Pain Bundle Vs. ERAS-cardiac for Postoperative Delirium","status":"NOT_YET_RECRUITING","sponsor":"Beth Israel Deaconess Medical Center","startDate":"2025-02-01","conditions":"Delirium, Postoperative, Delirium in Old Age","enrollment":406},{"nctId":"NCT05672784","phase":"NA","title":"Genicular Nerve Block Versus Its Combination With Infiltration Between Popliteal Artery and Capsule of Posterior Knee","status":"RECRUITING","sponsor":"Zagazig University","startDate":"2022-11-05","conditions":"Postoperative Pain","enrollment":63},{"nctId":"NCT04254679","phase":"PHASE2, PHASE3","title":"Pilot Trial: Postoperative Opioid-free Analgesia","status":"COMPLETED","sponsor":"McGill University Health Centre/Research Institute of the McGill University Health Centre","startDate":"2020-01-29","conditions":"Outpatient Surgery, Abdominal Surgery, Breast Surgery","enrollment":81},{"nctId":"NCT06656299","phase":"NA","title":"EOIB for Laparoscopic Cholecystectomy","status":"RECRUITING","sponsor":"Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital","startDate":"2024-10-30","conditions":"Cholecystitis, Cholecystitis, Acute, Cholecystitis, Chronic","enrollment":60},{"nctId":"NCT04147013","phase":"PHASE4","title":"Effect of Celecoxib on Postoperative Analgesia and Disease Severity in AERD Patients with CRS","status":"ACTIVE_NOT_RECRUITING","sponsor":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","startDate":"2020-02-18","conditions":"Chronic Rhinosinusitis with Nasal Polyps, Aspirin-exacerbated Respiratory Disease","enrollment":44},{"nctId":"NCT05158270","phase":"NA","title":"Erector Spinae Plane Block Versus Subcostal Anterior Quadratus Lumborum Block in Laparoscopic Cholecystectomy","status":"COMPLETED","sponsor":"Zagazig University","startDate":"2021-11-15","conditions":"Laparoscopic Cholecystectomy, Quadratus Lumborum Block, Erector Spinae Plane Block","enrollment":81},{"nctId":"NCT03859024","phase":"PHASE4","title":"Efficacy of Opioid-limiting Pain Management Protocol in Men Undergoing Urethroplasty","status":"COMPLETED","sponsor":"University of Alabama at Birmingham","startDate":"2019-03-22","conditions":"Pain, Postoperative, Urethral Stricture","enrollment":48},{"nctId":"NCT03467750","phase":"PHASE4","title":"Effect of Ketorolac on Post Adenotonsillectomy Pain","status":"COMPLETED","sponsor":"Emory University","startDate":"2018-07-19","conditions":"Obstructive Sleep Apnea","enrollment":63},{"nctId":"NCT04879823","phase":"PHASE3","title":"Post-operative Course of Dexamethasone to Reduce Tonsillectomy Morbidity","status":"TERMINATED","sponsor":"David Chi, MD","startDate":"2021-08-05","conditions":"Adenotonsillectomy, Analgesia, Surgery","enrollment":222},{"nctId":"NCT04791761","phase":"PHASE1, PHASE2","title":"Non-Opioid Pain Medications After Intracapsular Adenotonsillectomy","status":"TERMINATED","sponsor":"David Chi, MD","startDate":"2021-04-13","conditions":"Adenotonsillectomy, Post-operative Analgesia, Opioid Use","enrollment":73},{"nctId":"NCT04973748","phase":"NA","title":"Conditioned Open-label Placebo (COLP) for Peri-operative Pain Management in Patients With Head and Neck Cancer","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2023-02-07","conditions":"Postoperative Pain, Opioid Use","enrollment":9},{"nctId":"NCT04469868","phase":"NA","title":"No Opioids PrescrIptions On Discharge After Surgery","status":"COMPLETED","sponsor":"Albany Medical College","startDate":"2018-12-15","conditions":"Opioid Use, Prescription Drug Abuse and Dependency, Surgery","enrollment":350},{"nctId":"NCT04811209","phase":"","title":"MCID and PASS for Acute Pain and Quality of Recovery After Orthopedic Surgery","status":"RECRUITING","sponsor":"University Health Network, Toronto","startDate":"2021-06-21","conditions":"Pain Management","enrollment":300},{"nctId":"NCT06514222","phase":"EARLY_PHASE1","title":"Pain Control Following Third Molar Surgery","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Sharjah","startDate":"2024-07-01","conditions":"Post Operative Pain, Impacted Third Molar Tooth","enrollment":56},{"nctId":"NCT06478758","phase":"PHASE4","title":"Ibuprofen Use on Post-operative Pain Following Cholecystectomy","status":"COMPLETED","sponsor":"Giresun University","startDate":"2024-02-01","conditions":"Acute Post-operative Pain","enrollment":71},{"nctId":"NCT06420388","phase":"NA","title":"2% Lidocaine Gel in Reducing Postoperative Pain Following Haemorrhoidectomy","status":"RECRUITING","sponsor":"E-DA Hospital","startDate":"2023-05-01","conditions":"Surgery, Pain, Postoperative","enrollment":400},{"nctId":"NCT06417268","phase":"PHASE2","title":"Combined Pericapsular Nerve Group Block and Lateral Femoral Cutaneous Nerve Block for Pediatric Hip Surgeries","status":"RECRUITING","sponsor":"Kasr El Aini Hospital","startDate":"2024-03-01","conditions":"Pericapsular Nerve Group Block","enrollment":68},{"nctId":"NCT06397807","phase":"","title":"Postoperative Pain Management on Patients Undergoing Lung Tumor Resection","status":"NOT_YET_RECRUITING","sponsor":"China Medical University Hospital","startDate":"2024-05-31","conditions":"Postoperative Pain, Lung Cancer, Lung Tumor","enrollment":400},{"nctId":"NCT03867539","phase":"PHASE4","title":"Exparel and Education to Avoid Opioids After Carpal Tunnel Release","status":"RECRUITING","sponsor":"Kettering Health Network","startDate":"2019-02-15","conditions":"Carpal Tunnel Syndrome","enrollment":64},{"nctId":"NCT04790812","phase":"PHASE4","title":"Preemptive Analgesia With Celecoxib for Acute Dental Pain Management","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2021-04-22","conditions":"Pain, Postoperative","enrollment":65},{"nctId":"NCT06304181","phase":"NA","title":"Effect of Paracetamol and Mannitol Injection on Postoperative Analgesia in Patients With Thoracoscopic Lobectomy","status":"NOT_YET_RECRUITING","sponsor":"The Fourth Affiliated Hospital of Zhejiang University School of Medicine","startDate":"2024-03-15","conditions":"Postoperative Analgesia","enrollment":90},{"nctId":"NCT04905563","phase":"PHASE4","title":"NSAIDs vs Opioids for Post-op Pain in Supracondylar Humerus Fractures","status":"TERMINATED","sponsor":"Le Bonheur Children's Hospital","startDate":"2021-06-07","conditions":"Supracondylar Humerus Fracture","enrollment":30},{"nctId":"NCT04010266","phase":"NA","title":"RelieVRx for Total Knee Arthroplasty (TKA) for the Reduction of Acute Postoperative Pain and Opioid Use","status":"COMPLETED","sponsor":"AppliedVR Inc.","startDate":"2021-03-01","conditions":"Opioid Use, Arthropathy of Knee, Pain, Postoperative","enrollment":63},{"nctId":"NCT04990804","phase":"PHASE4","title":"Opioid Free vs. Standard Perioperative Pain Regimen for Anterior Cervical Discectomy and Fusion (ACDF) Surgery","status":"TERMINATED","sponsor":"Vanderbilt University Medical Center","startDate":"2021-08-01","conditions":"Opioid Use, Spinal Diseases, Surgery--Complications","enrollment":8},{"nctId":"NCT03738904","phase":"PHASE4","title":"Prospective Randomized Controlled Trial of an Enhanced Recovery Protocol for Anorectal Surgery","status":"COMPLETED","sponsor":"Cedars-Sinai Medical Center","startDate":"2018-10-26","conditions":"Anorectal Disorder","enrollment":111},{"nctId":"NCT03389243","phase":"NA","title":"Paracetamol and Metamizole With SPI-guided Anaesthesia for VRS","status":"COMPLETED","sponsor":"Medical University of Silesia","startDate":"2018-01-15","conditions":"Vitreoretinal Surgeries, Postoperative Nausea and Vomiting, Postoperative Pain","enrollment":165},{"nctId":"NCT03415555","phase":"PHASE4","title":"Postoperative Analgesia After Minithoracotomy","status":"COMPLETED","sponsor":"Medical University of Lublin","startDate":"2018-02-07","conditions":"Postoperative Pain, Mitral Valve Disease","enrollment":19},{"nctId":"NCT02804126","phase":"PHASE4","title":"Comparison of Two Pain-treatment Techniques After Cesarean Section","status":"COMPLETED","sponsor":"Michał Borys","startDate":"2017-06-01","conditions":"Cesarean Section, Pain Management, Neuropathic Pain","enrollment":232},{"nctId":"NCT03404908","phase":"PHASE4","title":"TAP vs QLB in Patients After Cesarean Delivery","status":"COMPLETED","sponsor":"Medical University of Lublin","startDate":"2018-02-07","conditions":"Cesarean Section, Postoperative Pain","enrollment":105},{"nctId":"NCT06120088","phase":"","title":"U.S. Guided Erector Spinae Block for Postoperative Pain Management in Paraumbilical Hernia Repair Patients","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2023-12-01","conditions":"Regional Anesthesia","enrollment":300},{"nctId":"NCT06050551","phase":"NA","title":"Pigtail or Chest Tube Placement After Uniportal Video-assisted Thoracoscopic Surgery","status":"UNKNOWN","sponsor":"National Cheng-Kung University Hospital","startDate":"2023-03-08","conditions":"Post Operative Pain, Acute, Post-Op Complication, Opioid Use, Unspecified","enrollment":40},{"nctId":"NCT05316168","phase":"PHASE3","title":"Post Operative Pain Management for ACL Reconstruction","status":"UNKNOWN","sponsor":"Rothman Institute Orthopaedics","startDate":"2023-09-30","conditions":"Pain, Postoperative","enrollment":154}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1233,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Postoperative pain management with acetaminophen","genericName":"Postoperative pain management with acetaminophen","companyName":"University Hospital Sestre Milosrdnice","companyId":"university-hospital-sestre-milosrdnice","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Acetaminophen reduces pain and fever by inhibiting prostaglandin synthesis in the central nervous system. Used for Postoperative pain management, Fever reduction, Mild to moderate pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}