{"id":"postop-orphenadrine-iv","safety":{"commonSideEffects":[{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Urinary retention"},{"rate":null,"effect":"Blurred vision"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Orphenadrine acts as a competitive antagonist at muscarinic cholinergic receptors, which reduces acetylcholine-mediated muscle contraction and spasm. It also has local anesthetic and analgesic properties that contribute to pain relief. The IV formulation is used in acute postoperative settings for rapid onset of muscle relaxation and pain management.","oneSentence":"Orphenadrine is an anticholinergic agent that blocks muscarinic acetylcholine receptors to reduce muscle spasms and provide analgesic effects.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:42:18.972Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postoperative muscle spasm and pain relief"},{"name":"Acute musculoskeletal pain management"}]},"trialDetails":[{"nctId":"NCT05413902","phase":"PHASE4","title":"Multi-Modal Anesthesia Protocol in Pain Management of Patients Undergoing Posterior Lumbar Spinal Fusion Surgery","status":"COMPLETED","sponsor":"University of Puerto Rico","startDate":"2021-04-05","conditions":"Pain Management, Posterior Spinal Fusion","enrollment":100},{"nctId":"NCT02449369","phase":"PHASE4","title":"Intra-Venous Acetaminophen and Muscle Relaxants After Total Knee","status":"COMPLETED","sponsor":"AdventHealth","startDate":"2015-04","conditions":"Unilateral Knee Arthroplasty","enrollment":180},{"nctId":"NCT02958566","phase":"PHASE4","title":"Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery","status":"UNKNOWN","sponsor":"University of Illinois College of Medicine at Peoria","startDate":"2017-01","conditions":"Colon Cancer, Colon Diverticulosis, Colonic Neoplasms","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Norflex"],"phase":"marketed","status":"active","brandName":"Postop orphenadrine IV","genericName":"Postop orphenadrine IV","companyName":"AdventHealth","companyId":"adventhealth","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Orphenadrine is an anticholinergic agent that blocks muscarinic acetylcholine receptors to reduce muscle spasms and provide analgesic effects. Used for Postoperative muscle spasm and pain relief, Acute musculoskeletal pain management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}