{"id":"postop-hydromorphone-iv","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Hypotension"}]},"_chembl":{"chemblId":"CHEMBL1237055","moleculeType":"Small molecule","molecularWeight":"321.80"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Hydromorphone activates mu-opioid receptors in the brain and spinal cord, inhibiting pain signal transmission and modulating pain perception. This results in potent analgesia suitable for moderate to severe acute pain. The IV formulation provides rapid onset of action, making it appropriate for postoperative pain management in hospital settings.","oneSentence":"Hydromorphone is a mu-opioid receptor agonist that binds to opioid receptors in the central nervous system to produce analgesia and sedation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:01:55.167Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postoperative pain management"}]},"trialDetails":[{"nctId":"NCT06525740","phase":"PHASE4","title":"Methadone Versus Intrathecal Hydromorphone for Postoperative Pain Relief in Gynecologic Cancer Undergoing Surgery","status":"RECRUITING","sponsor":"Mayo Clinic","startDate":"2024-09-03","conditions":"Malignant Female Reproductive System Neoplasm","enrollment":140},{"nctId":"NCT03715517","phase":"NA","title":"Spinal Anesthesia For Enhanced Recovery After Liver Surgery","status":"RECRUITING","sponsor":"University of Manitoba","startDate":"2018-10-04","conditions":"Hepatectomy, Pain, Postoperative, Liver Neoplasms","enrollment":128},{"nctId":"NCT05279898","phase":"NA","title":"Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies","status":"COMPLETED","sponsor":"Beth Israel Deaconess Medical Center","startDate":"2023-02-28","conditions":"Postoperative Delirium, Hemodynamic Instability, Pain","enrollment":70},{"nctId":"NCT07092475","phase":"PHASE3","title":"The Impact of Intraoperative Methadone on Postoperative Opioid Use","status":"WITHDRAWN","sponsor":"University of Utah","startDate":"2025-11","conditions":"Breast Cancer, Opioid Use","enrollment":""},{"nctId":"NCT03726268","phase":"PHASE4","title":"Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement)","status":"COMPLETED","sponsor":"Duke University","startDate":"2018-11-29","conditions":"Opioid Use, Pain, Postoperative","enrollment":907},{"nctId":"NCT05842044","phase":"PHASE2","title":"NSAID Use After Robotic Partial Nephrectomy","status":"RECRUITING","sponsor":"University of Miami","startDate":"2023-09-15","conditions":"Kidney Cancer, Renal Cancer, Renal Neoplasm","enrollment":110},{"nctId":"NCT05231460","phase":"PHASE4","title":"Pain Management Study","status":"ENROLLING_BY_INVITATION","sponsor":"University of Arizona","startDate":"2022-02-18","conditions":"Pain, Postoperative","enrollment":244},{"nctId":"NCT06559969","phase":"PHASE2, PHASE3","title":"IV vs Epidural Opioids + Epidural Local Anesthetic for Laparotomy Analgesia","status":"RECRUITING","sponsor":"University of Iowa","startDate":"2024-09-17","conditions":"Laparotomy","enrollment":80},{"nctId":"NCT03020875","phase":"PHASE4","title":"IV vs Oral Acetaminophen in Spine Fusion Perioperative Care","status":"ENROLLING_BY_INVITATION","sponsor":"Hospital for Special Surgery, New York","startDate":"2017-01","conditions":"Multimodal Analgesic Approach","enrollment":166},{"nctId":"NCT05693675","phase":"PHASE2, PHASE3","title":"Postoperative Oral Methadone After Major Spine Surgery; Safety, Feasibility and Efficacy in Prevention of Progression to Chronic Opioid Usage at 3 Months","status":"WITHDRAWN","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2023-10-01","conditions":"Spine Surgery","enrollment":""},{"nctId":"NCT03987022","phase":"PHASE4","title":"ICE-T Pain Regimen for Total Laparoscopic Hysterectomy","status":"COMPLETED","sponsor":"MetroHealth Medical Center","startDate":"2019-08-01","conditions":"Opioid Substitution Treatment","enrollment":66},{"nctId":"NCT04811209","phase":"","title":"MCID and PASS for Acute Pain and Quality of Recovery After Orthopedic Surgery","status":"RECRUITING","sponsor":"University Health Network, Toronto","startDate":"2021-06-21","conditions":"Pain Management","enrollment":300},{"nctId":"NCT05252858","phase":"NA","title":"A Pilot Study Investigating the nCAP Signal Relief Patch in Subjects Undergoing Primary Hip or Knee Replacement Surgery","status":"COMPLETED","sponsor":"Jacques E. Chelly","startDate":"2022-03-21","conditions":"Opioid Use, Pain, Post Operative","enrollment":79},{"nctId":"NCT03115151","phase":"PHASE4","title":"Epidural and Intravenous Patient-Controlled Analgesia Following Lumbar Spinal Fusion Surgery","status":"TERMINATED","sponsor":"University of Texas Southwestern Medical Center","startDate":"2017-05-08","conditions":"Pain","enrollment":46},{"nctId":"NCT04429022","phase":"PHASE3","title":"Multimodal Pain Management After Robotic-Assisted Total Laparoscopic Hysterectomy","status":"COMPLETED","sponsor":"State University of New York at Buffalo","startDate":"2020-11-24","conditions":"Pain, Postoperative","enrollment":68},{"nctId":"NCT03052816","phase":"PHASE4","title":"Ice T Postoperative Multimodal Pain Regimen in FPMRS Surgery","status":"COMPLETED","sponsor":"University Hospitals Cleveland Medical Center","startDate":"2017-04-01","conditions":"Pain, Postoperative, Pelvic Organ Prolapse","enrollment":66},{"nctId":"NCT04464512","phase":"PHASE4","title":"Suboxone User Perioperative Early Referral and Enhanced Recovery After Surgery- Orthopaedic Trauma Surgery Population","status":"WITHDRAWN","sponsor":"West Virginia University","startDate":"2020-01-10","conditions":"Addiction Opiate, Chronic Pain, Fractures, Bone","enrollment":""},{"nctId":"NCT04639011","phase":"PHASE4","title":"Duloxetine Tibial Plateau","status":"WITHDRAWN","sponsor":"Boston Medical Center","startDate":"2022-10","conditions":"Tibial Plateau Fracture, Pain, Postoperative","enrollment":""},{"nctId":"NCT05200806","phase":"PHASE4","title":"A Prospective Pilot Study of a Non-Narcotic Post-Operative Course After Colectomy","status":"UNKNOWN","sponsor":"University of Vermont","startDate":"2022-02-07","conditions":"Analgesia, Post-Operative Pain, Breakthrough Pain","enrollment":25},{"nctId":"NCT02219581","phase":"PHASE4","title":"Steroids in Total Knee Arthroplasty","status":"TERMINATED","sponsor":"Thomas L Bradbury","startDate":"2014-10-16","conditions":"Postoperative Pain, Inflammation, Osteoarthritis","enrollment":1},{"nctId":"NCT03282669","phase":"PHASE4","title":"TC02 Obese Women Using It Morphine vs PCA IV Hydromorphone for Post-Cesarean Analgesia","status":"WITHDRAWN","sponsor":"Northwestern University","startDate":"2019-08","conditions":"Pain, Postoperative, Obesity, Respiratory Insufficiency","enrollment":""},{"nctId":"NCT01335542","phase":"PHASE4","title":"Analgesia After Total Knee Arthroplasty: Peri-Articular Injection Versus Epidural + Femoral Nerve Blockade","status":"COMPLETED","sponsor":"Hospital for Special Surgery, New York","startDate":"2010-03","conditions":"Readiness to Discharge","enrollment":91},{"nctId":"NCT03330119","phase":"PHASE3","title":"Determining the Effect of an \"Alternate Recovery Protocol\" Versus Current Standard of Care After Cesarean Section","status":"TERMINATED","sponsor":"Brest, Norman A., M.D.","startDate":"2017-10-04","conditions":"Pregnancy Related, Narcotic Use","enrollment":1494},{"nctId":"NCT02056301","phase":"PHASE4","title":"A Comparison Trial Between PCA and Epidural Analgesia for Pectus Excavatum Repair","status":"TERMINATED","sponsor":"Baylor College of Medicine","startDate":"2012-08","conditions":"Pectus Excavatum","enrollment":62},{"nctId":"NCT03104816","phase":"PHASE4","title":"The Effectiveness of IV/PO Acetaminophen in the Perioperative Period in Reducing Opiate Use After Lumbar Spine Fusion","status":"TERMINATED","sponsor":"University of Southern California","startDate":"2016-10","conditions":"Fusion of Spine, Lumbar Region","enrollment":28},{"nctId":"NCT02987920","phase":"PHASE4","title":"Dextromethorphan Use in Multimodal Analgesia Regimens for Total Knee Arthroplasty","status":"TERMINATED","sponsor":"University of Southern California","startDate":"2017-01","conditions":"Pain, Postoperative","enrollment":23},{"nctId":"NCT02190903","phase":"NA","title":"A Trial To Assess Risk of Delirium in Older Adults Undergoing Hip Fracture Surgery With Spinal or General Anesthesia","status":"COMPLETED","sponsor":"University of Pennsylvania","startDate":"2013-10","conditions":"Postoperative Complications, Hip Fracture, Delirium","enrollment":15},{"nctId":"NCT02449369","phase":"PHASE4","title":"Intra-Venous Acetaminophen and Muscle Relaxants After Total Knee","status":"COMPLETED","sponsor":"AdventHealth","startDate":"2015-04","conditions":"Unilateral Knee Arthroplasty","enrollment":180},{"nctId":"NCT01591382","phase":"PHASE4","title":"Efficacy Study of Ketamine for Postoperative Pain in Opioid Dependent Patients","status":"COMPLETED","sponsor":"Brigham and Women's Hospital","startDate":"2008-09","conditions":"Postoperative Pain","enrollment":64},{"nctId":"NCT02958566","phase":"PHASE4","title":"Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery","status":"UNKNOWN","sponsor":"University of Illinois College of Medicine at Peoria","startDate":"2017-01","conditions":"Colon Cancer, Colon Diverticulosis, Colonic Neoplasms","enrollment":80},{"nctId":"NCT01986946","phase":"PHASE3","title":"Epidural Analgesia Versus IV Analgesia in Lumbar Spine Fusions","status":"TERMINATED","sponsor":"Duke University","startDate":"2013-10","conditions":"Lumbar Spine Fusion, Pain, Back Pain","enrollment":17},{"nctId":"NCT02110719","phase":"PHASE4","title":"Decreasing Narcotics in Advanced Pelvic Surgery","status":"COMPLETED","sponsor":"Hartford Hospital","startDate":"2014-03","conditions":"Narcotic Use, Pain, Constipation","enrollment":138},{"nctId":"NCT01568437","phase":"PHASE3","title":"Transversus Abdominis Plane (TAP) Block in Laparoscopic Gastric-bypass Surgery","status":"COMPLETED","sponsor":"University Health Network, Toronto","startDate":"2012-01","conditions":"Gastric-bypass Surgery, Opioid Consumption, Obesity","enrollment":70},{"nctId":"NCT02491385","phase":"NA","title":"Thoracic Epidural for Postoperative Ileus","status":"COMPLETED","sponsor":"Samsung Medical Center","startDate":"2014-04","conditions":"Ileus","enrollment":28},{"nctId":"NCT02361775","phase":"EARLY_PHASE1","title":"Paravertebral Catheters for VATS Procedures","status":"COMPLETED","sponsor":"University of Minnesota","startDate":"2012-07","conditions":"Acute Pain","enrollment":50},{"nctId":"NCT01582490","phase":"PHASE4","title":"Study of EXPAREL in Patients Undergoing Breast Augmentation","status":"COMPLETED","sponsor":"Pacira Pharmaceuticals, Inc","startDate":"2012-04","conditions":"Mammoplasty, Postoperative Pain","enrollment":19},{"nctId":"NCT00295945","phase":"","title":"Epidural Analgesia or Patient-Controlled Analgesia in Treating Patients Who Have Undergone Surgery for Gynecologic Cancer","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2005-03","conditions":"Cervical Cancer, Endometrial Cancer, Fallopian Tube Cancer","enrollment":240},{"nctId":"NCT01908491","phase":"PHASE4","title":"Comparison of IV PCA and Wound Infusion After Repair of Pectus Excavatum","status":"COMPLETED","sponsor":"The Catholic University of Korea","startDate":"2012-10","conditions":"Pain, Side Effects","enrollment":80},{"nctId":"NCT00790179","phase":"NA","title":"Continuous Lumbar Plexus Block for Postoperative Pain Control After Total Hip Arthroplasty","status":"COMPLETED","sponsor":"Northwell Health","startDate":"2003-01","conditions":"Postoperative Pain","enrollment":225}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Dilaudid"],"phase":"marketed","status":"active","brandName":"Postop hydromorphone IV","genericName":"Postop hydromorphone IV","companyName":"AdventHealth","companyId":"adventhealth","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hydromorphone is a mu-opioid receptor agonist that binds to opioid receptors in the central nervous system to produce analgesia and sedation. Used for Postoperative pain management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}