{"id":"postmenopausal-topical-vaginal-estrogen-cream","safety":{"commonSideEffects":[{"rate":null,"effect":"Vaginal irritation or burning"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Vaginal discharge"}]},"_chembl":{"chemblId":"CHEMBL2108947","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Postmenopausal vaginal atrophy results from declining estrogen levels, causing vaginal dryness, irritation, and dyspareunia. Topical vaginal estrogen cream is applied directly to the vaginal epithelium, where it is absorbed locally to restore tissue elasticity, increase vaginal lubrication, and normalize the vaginal microenvironment. This localized delivery minimizes systemic estrogen exposure compared to oral hormone replacement therapy.","oneSentence":"Topical vaginal estrogen cream delivers estrogen directly to vaginal tissues to restore estrogen levels and alleviate symptoms of vaginal atrophy in postmenopausal women.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:01:56.675Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postmenopausal vaginal atrophy (genitourinary syndrome of menopause)"},{"name":"Vaginal dryness and dyspareunia in postmenopausal women"}]},"trialDetails":[{"nctId":"NCT06873971","phase":"NA","title":"Er:YAG Laser Combined With Vaginal Estriol for Genitourinary Syndrome of Menopause","status":"RECRUITING","sponsor":"University of Nove de Julho","startDate":"2025-12-10","conditions":"Genitourinary Syndrome of Menopause","enrollment":60},{"nctId":"NCT01886794","phase":"PHASE4","title":"Hormonal Status on Blood Flow and Tissue in Pelvic Organ Prolapse","status":"TERMINATED","sponsor":"The University of Texas Medical Branch, Galveston","startDate":"2013-06-06","conditions":"Pelvic Floor Disorders","enrollment":7},{"nctId":"NCT05863975","phase":"PHASE4","title":"Treatment of HPV Infection in Perimenopausal and Postmenopausal Women","status":"UNKNOWN","sponsor":"Qianfoshan Hospital","startDate":"2023-07-01","conditions":"HPV Infection","enrollment":150},{"nctId":"NCT05118685","phase":"PHASE1","title":"Estrogen and Platelet Rich Plasma in Treatment of Atrophic Vaginitis","status":"UNKNOWN","sponsor":"Fayoum University","startDate":"2021-11-13","conditions":"Atrophic Vaginitis, Postmenopausal Atrophic Vaginitis","enrollment":100},{"nctId":"NCT02869165","phase":"PHASE4","title":"Vaginal and Urinary Microbiome Trial","status":"COMPLETED","sponsor":"University of Louisville","startDate":"2017-01","conditions":"Atrophic Vaginitis, Menopause, Recurrent Urinary Tract Infections","enrollment":110},{"nctId":"NCT02419729","phase":"PHASE3","title":"Evaluation of Fractional CO2 Laser Treatment Efficacy and Comparison to Vaginal Estrogen Therapy in Postmenopausal Women With Vulvovaginal Atrophy","status":"COMPLETED","sponsor":"Faculdade de Medicina do ABC","startDate":"2015-03","conditions":"Vulvovaginal Atrophy","enrollment":45}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Estrace vaginal cream"],"phase":"marketed","status":"active","brandName":"Postmenopausal, topical vaginal estrogen cream","genericName":"Postmenopausal, topical vaginal estrogen cream","companyName":"The University of Texas Medical Branch, Galveston","companyId":"the-university-of-texas-medical-branch-galveston","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Topical vaginal estrogen cream delivers estrogen directly to vaginal tissues to restore estrogen levels and alleviate symptoms of vaginal atrophy in postmenopausal women. Used for Postmenopausal vaginal atrophy (genitourinary syndrome of menopause), Vaginal dryness and dyspareunia in postmenopausal women.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}