{"id":"post-cpb-drug-dobutamine-hydrochloride","safety":{"commonSideEffects":[{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Arrhythmias"},{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Tremor"}]},"_chembl":{"chemblId":"CHEMBL1200418","moleculeType":"Small molecule","molecularWeight":"337.85"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dobutamine selectively stimulates beta-1 adrenergic receptors on cardiac myocytes, increasing intracellular cAMP and enhancing myocardial contractility. It is commonly used in the post-cardiopulmonary bypass period to support cardiac function and improve hemodynamics when the heart has been temporarily stopped and requires inotropic support to resume adequate perfusion.","oneSentence":"Dobutamine is a beta-1 adrenergic agonist that increases cardiac contractility and heart rate to improve cardiac output in patients with low cardiac function.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:01:53.500Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inotropic support in the immediate post-cardiopulmonary bypass period"},{"name":"Acute decompensated heart failure with reduced cardiac output"}]},"trialDetails":[{"nctId":"NCT05025644","phase":"PHASE4","title":"Quantitative Assessment of Hypertrophic Obstructive Cardiomyopathy With Intraoperative Three-dimensional Transesophageal Echocardiography Under Provocative Dobutamine Stress Test","status":"UNKNOWN","sponsor":"University Health Network, Toronto","startDate":"2023-03","conditions":"Hypertrophic Obstructive Cardiomyopathy","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Transthoracic or 2D Echocardiogram","Transesophageal Echocardiogram (TEE)"],"phase":"marketed","status":"active","brandName":"Post-CPB Drug: Dobutamine Hydrochloride","genericName":"Post-CPB Drug: Dobutamine Hydrochloride","companyName":"University Health Network, Toronto","companyId":"university-health-network-toronto","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dobutamine is a beta-1 adrenergic agonist that increases cardiac contractility and heart rate to improve cardiac output in patients with low cardiac function. Used for Inotropic support in the immediate post-cardiopulmonary bypass period, Acute decompensated heart failure with reduced cardiac output.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}