{"id":"posaconazole-delayed-release-oral-tablet","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Nausea"},{"rate":"8-12","effect":"Diarrhea"},{"rate":"5-10","effect":"Vomiting"},{"rate":"5-8","effect":"Headache"},{"rate":"5-8","effect":"Abdominal pain"},{"rate":"5-10","effect":"Elevated liver enzymes"}]},"_chembl":{"chemblId":"CHEMBL1397","moleculeType":"Small molecule","molecularWeight":"700.79"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Posaconazole is a triazole antifungal that selectively inhibits the cytochrome P450-dependent enzyme lanosterol 14α-demethylase in fungi. This blocks the synthesis of ergosterol, an essential component of the fungal cell membrane, leading to membrane instability and fungal cell death. The delayed-release formulation improves bioavailability and allows for more consistent plasma concentrations.","oneSentence":"Posaconazole inhibits fungal cell membrane synthesis by blocking lanosterol 14α-demethylase, a key enzyme in ergosterol production.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:42:13.073Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prophylaxis of invasive fungal infections in high-risk immunocompromised patients"},{"name":"Treatment of oropharyngeal candidiasis"},{"name":"Treatment of invasive aspergillosis"}]},"trialDetails":[{"nctId":"NCT04966585","phase":"PHASE4","title":"Pilot Study of Posaconazole in Crohn's Disease","status":"TERMINATED","sponsor":"Cedars-Sinai Medical Center","startDate":"2022-08-17","conditions":"Crohn Disease, CARD9 S12N Risk Allele","enrollment":10},{"nctId":"NCT05468372","phase":"PHASE2","title":"Amphotericin Versus Posaconazole for Pulmonary Mucormycosis","status":"RECRUITING","sponsor":"Post Graduate Institute of Medical Education and Research, Chandigarh","startDate":"2022-07-01","conditions":"Mucormycosis; Pulmonary (Etiology)","enrollment":50},{"nctId":"NCT03763396","phase":"EARLY_PHASE1","title":"Azoles Targeting Recurrent High Grade Gliomas","status":"NOT_YET_RECRUITING","sponsor":"University Health Network, Toronto","startDate":"2024-06-01","conditions":"Brain Tumor, Recurrent, Cancer, Advanced, Glioma of Brain","enrollment":30},{"nctId":"NCT03434704","phase":"PHASE2","title":"Peripheral Blood Stem Cell Transplantation From Family Haploidentical Donors in Patients With Myelodysplastic Syndrome and Acute Leukemia Under Primary Prophylaxis With Posaconazole","status":"COMPLETED","sponsor":"Ciceri Fabio","startDate":"2018-06-18","conditions":"Transplant-Related Hematologic Malignancy, Leukemia, Acute, Myelodysplastic Syndromes","enrollment":10},{"nctId":"NCT03760445","phase":"PHASE1, PHASE2","title":"HDM201 Added to CT in R/R or Newly Diagnosed AML","status":"WITHDRAWN","sponsor":"Novartis Pharmaceuticals","startDate":"2019-11-15","conditions":"Leukemia, Myeloid, Acute","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Noxafil"],"phase":"marketed","status":"active","brandName":"Posaconazole Delayed Release Oral Tablet","genericName":"Posaconazole Delayed Release Oral Tablet","companyName":"Cedars-Sinai Medical Center","companyId":"cedars-sinai-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Posaconazole inhibits fungal cell membrane synthesis by blocking lanosterol 14α-demethylase, a key enzyme in ergosterol production. Used for Prophylaxis of invasive fungal infections in high-risk immunocompromised patients, Treatment of oropharyngeal candidiasis, Treatment of invasive aspergillosis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}