{"id":"porcine-fibrin-sealant-pfs","safety":{"commonSideEffects":[{"rate":"null","effect":"Hypersensitivity reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"PFS contains fibrinogen and thrombin, which are essential components in the coagulation cascade. When applied topically, these proteins convert to fibrin, forming a stable clot that seals tissues and promotes healing.","oneSentence":"Porcine Fibrin Sealant (PFS) works by promoting hemostasis and tissue sealing through the formation of a fibrin clot.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:29:42.058Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hemostasis in surgical procedures"}]},"trialDetails":[{"nctId":"NCT03847857","phase":"PHASE3","title":"Study of Porcine Fibrin Sealant in Preventing Cervical Anastomotic Leakage (PLACE030)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Sun Yat-sen University","startDate":"2019-02-21","conditions":"Esophageal Anastomotic Leak","enrollment":360},{"nctId":"NCT03529266","phase":"PHASE2","title":"Study of Porcine Fibrin Sealant in Preventing Cervical Anastomotic Leakage for Esophageal or Junctional Carcinoma.","status":"COMPLETED","sponsor":"Sun Yat-sen University","startDate":"2018-06-01","conditions":"Esophageal Cancer, Gastroesophageal Junction Cancer, Anastomotic Leak","enrollment":57}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Bioseal®"],"phase":"phase_3","status":"active","brandName":"Porcine Fibrin Sealant (PFS)","genericName":"Porcine Fibrin Sealant (PFS)","companyName":"Sun Yat-sen University","companyId":"sun-yat-sen-university","modality":"Biologic","firstApprovalDate":"","aiSummary":"Porcine Fibrin Sealant (PFS) works by promoting hemostasis and tissue sealing through the formation of a fibrin clot. Used for Hemostasis in surgical procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}