{"id":"poractant-alfa-intratracheal-suspension-curosurf","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Apnea"},{"rate":"5-10%","effect":"Pneumothorax"},{"rate":"5-10%","effect":"Bronchopulmonary dysplasia"}]},"_chembl":{"chemblId":"CHEMBL1201622","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Surfactant is a naturally occurring substance in the lungs that helps to reduce the surface tension of water, making it easier to breathe. Poractant alfa is a synthetic version of this substance, which is administered intratracheally to help improve lung function in premature infants with respiratory distress syndrome.","oneSentence":"Poractant alfa is a surfactant replacement therapy that helps to reduce the surface tension in the lungs, facilitating easier breathing.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:29:39.320Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Respiratory distress syndrome in premature infants"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Curosurf®","Surfactant endotracheal administration following a recruitment HFOV manoeuvre"],"phase":"phase_3","status":"active","brandName":"Poractant Alfa Intratracheal Suspension [Curosurf]","genericName":"Poractant Alfa Intratracheal Suspension [Curosurf]","companyName":"Hospital Clinic of Barcelona","companyId":"hospital-clinic-of-barcelona","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Poractant alfa is a surfactant replacement therapy that helps to reduce the surface tension in the lungs, facilitating easier breathing. Used for Respiratory distress syndrome in premature infants.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}