{"id":"polysporin-triple","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation or rash"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Sensitization to neomycin"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Polysporin Triple contains bacitracin, neomycin, and polymyxin B, three antibiotics with complementary mechanisms of action. Bacitracin inhibits bacterial cell wall synthesis, neomycin inhibits protein synthesis by binding to the 30S ribosomal subunit, and polymyxin B disrupts bacterial cell membranes. This triple combination provides broad-spectrum coverage against common skin pathogens.","oneSentence":"Polysporin Triple is a topical antibiotic combination that kills bacteria by inhibiting protein synthesis and cell wall integrity through multiple mechanisms.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:01:51.882Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of infection in minor cuts, scrapes, and burns"},{"name":"Topical treatment of minor bacterial skin infections"}]},"trialDetails":[{"nctId":"NCT00990392","phase":"NA","title":"Topical Antibiotics for Prevention of Intensive Care Unit (ICU) Central Line Infections","status":"WITHDRAWN","sponsor":"Fraser Health","startDate":"2009-11","conditions":"Blood Stream Infections, Skin Diseases, Infectious","enrollment":""},{"nctId":"NCT00400595","phase":"PHASE4","title":"Use of Ointments in Prevention of Catheter Related Infections in PD","status":"COMPLETED","sponsor":"University Health Network, Toronto","startDate":"2006-02","conditions":"End Stage Renal Disease","enrollment":200},{"nctId":"NCT02002169","phase":"NA","title":"Hemodialysis Infection Prevention Using Polysporin Ointment With Shower Technique in Satellite Centres Pilot Study","status":"UNKNOWN","sponsor":"University Health Network, Toronto","startDate":"2012-12","conditions":"End Stage Renal Failure on Dialysis","enrollment":78}],"_emaApprovals":[],"_faersSignals":[{"count":3,"reaction":"COAGULATION TIME PROLONGED"},{"count":3,"reaction":"DRUG INTERACTION"},{"count":3,"reaction":"OFF LABEL USE"},{"count":2,"reaction":"ANXIETY"},{"count":2,"reaction":"COUGH"},{"count":2,"reaction":"FISTULA"},{"count":2,"reaction":"NASOPHARYNGITIS"},{"count":2,"reaction":"URTICARIA"},{"count":1,"reaction":"ABDOMINAL DISCOMFORT"},{"count":1,"reaction":"ABDOMINAL DISTENSION"}],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Polysporin Triple","genericName":"Polysporin Triple","companyName":"University Health Network, Toronto","companyId":"university-health-network-toronto","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Polysporin Triple is a topical antibiotic combination that kills bacteria by inhibiting protein synthesis and cell wall integrity through multiple mechanisms. Used for Prevention of infection in minor cuts, scrapes, and burns, Topical treatment of minor bacterial skin infections.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}