{"id":"polysporin-ointment","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or rash"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Itching or burning at application site"}]},"_chembl":{"chemblId":"CHEMBL2108523","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bacitracin inhibits bacterial cell wall synthesis by blocking dephosphorylation of lipid carriers essential for peptidoglycan formation. Polymyxin B disrupts bacterial cell membranes by binding to lipopolysaccharides and causing leakage of cellular contents. Together, these agents provide broad-spectrum coverage against gram-positive and gram-negative bacteria commonly found in skin infections.","oneSentence":"Polysporin Ointment combines two antibiotics (bacitracin and polymyxin B) that work synergistically to inhibit bacterial cell wall synthesis and disrupt cell membrane integrity.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:01:47.787Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Minor cuts, scrapes, and wounds"},{"name":"Prevention of infection in minor skin injuries"},{"name":"Topical treatment of minor bacterial skin infections"}]},"trialDetails":[{"nctId":"NCT05000983","phase":"PHASE1, PHASE2","title":"A Between Patient Study of Plurogel® Compared to Standard Topical Dressing in Burn Injuries","status":"RECRUITING","sponsor":"University of Manitoba","startDate":"2021-10-20","conditions":"Burns","enrollment":25},{"nctId":"NCT04893863","phase":"PHASE1, PHASE2","title":"A Study of Plurogel® Compared to Standard Topical Dressing in Burn Injuries","status":"RECRUITING","sponsor":"University of Manitoba","startDate":"2021-10-01","conditions":"Burns","enrollment":20},{"nctId":"NCT03199911","phase":"PHASE4","title":"Topical Antibiotic Prophylaxis for Eyelids","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2017-10-02","conditions":"Antibiotic Side Effect, Eyelid; Wound, Eyelid Diseases","enrollment":401},{"nctId":"NCT00695578","phase":"PHASE4","title":"Clinical Trial to Evaluate Biafine Cream Versus Standard Care in Subjects With Actinic Keratosis Post Cryotherapy","status":"COMPLETED","sponsor":"Wake Forest University","startDate":"2006-10","conditions":"Actinic Keratosis","enrollment":20},{"nctId":"NCT03715387","phase":"PHASE2, PHASE3","title":"Tacrolimus for Malar Edema","status":"UNKNOWN","sponsor":"University of British Columbia","startDate":"2018-10-10","conditions":"Edema Face","enrollment":100},{"nctId":"NCT02497326","phase":"NA","title":"Heparin for the Treatment of Burn Wound Pain","status":"UNKNOWN","sponsor":"King Edward Medical University","startDate":"2015-04","conditions":"Second Degree Burns","enrollment":36},{"nctId":"NCT00990392","phase":"NA","title":"Topical Antibiotics for Prevention of Intensive Care Unit (ICU) Central Line Infections","status":"WITHDRAWN","sponsor":"Fraser Health","startDate":"2009-11","conditions":"Blood Stream Infections, Skin Diseases, Infectious","enrollment":""},{"nctId":"NCT00400595","phase":"PHASE4","title":"Use of Ointments in Prevention of Catheter Related Infections in PD","status":"COMPLETED","sponsor":"University Health Network, Toronto","startDate":"2006-02","conditions":"End Stage Renal Disease","enrollment":200},{"nctId":"NCT01608880","phase":"NA","title":"Effect of Nitroglycerin Ointment on Mastectomy Flap Necrosis","status":"COMPLETED","sponsor":"University of British Columbia","startDate":"2012-08","conditions":"Mastectomy Flap Necrosis","enrollment":154},{"nctId":"NCT02002169","phase":"NA","title":"Hemodialysis Infection Prevention Using Polysporin Ointment With Shower Technique in Satellite Centres Pilot Study","status":"UNKNOWN","sponsor":"University Health Network, Toronto","startDate":"2012-12","conditions":"End Stage Renal Failure on Dialysis","enrollment":78},{"nctId":"NCT00674999","phase":"PHASE2, PHASE3","title":"Use of Amnion on Partial Thickness Burns","status":"WITHDRAWN","sponsor":"The University of Texas Medical Branch, Galveston","startDate":"2005-06","conditions":"Burn","enrollment":""}],"_emaApprovals":[],"_faersSignals":[{"count":4,"reaction":"OEDEMA PERIPHERAL"},{"count":3,"reaction":"ABDOMINAL DISTENSION"},{"count":3,"reaction":"ABDOMINAL PAIN"},{"count":3,"reaction":"ASTHENIA"},{"count":3,"reaction":"BALANCE DISORDER"},{"count":3,"reaction":"DEPRESSION"},{"count":3,"reaction":"DIARRHOEA"},{"count":3,"reaction":"DRUG INEFFECTIVE"},{"count":3,"reaction":"FALL"},{"count":3,"reaction":"FATIGUE"}],"_approvalHistory":[],"publicationCount":10,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Polysporin","Bacitracin"],"phase":"marketed","status":"active","brandName":"Polysporin Ointment","genericName":"Polysporin Ointment","companyName":"University of British Columbia","companyId":"university-of-british-columbia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Polysporin Ointment combines two antibiotics (bacitracin and polymyxin B) that work synergistically to inhibit bacterial cell wall synthesis and disrupt cell membrane integrity. Used for Minor cuts, scrapes, and wounds, Prevention of infection in minor skin injuries, Topical treatment of minor bacterial skin infections.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}