{"id":"polymyxin-e","safety":{"commonSideEffects":[{"rate":"20-50","effect":"Nephrotoxicity (acute kidney injury)"},{"rate":"10-30","effect":"Neurotoxicity (paresthesias, dizziness, vertigo)"},{"rate":null,"effect":"Neuromuscular blockade"},{"rate":null,"effect":"Fever"}]},"_chembl":null,"_dailymed":{"setId":"42593c25-244f-44bb-a783-65608f9ab891","title":"GOOD NEIGHBOR PHARMACY EMERGENCY PREPAREDNESS AND FIRST AID CONTAINS 167 PIECES (BENZALKONIUM CHLORIDE, LIDOCAINE, BACITRACIN ZINC, NEOMYCIN SULFATE, POLYMYXIN B SULFATE, WATER, ISOPROPYL ALCOHOL, BENZOCAINE, ASPIRIN, ETHYL ALCOHOL) KIT [AMERISOURCEBERGEN]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Polymyxin E is a cyclic polypeptide antibiotic that acts as a cationic surfactant, penetrating and destabilizing the outer and inner membranes of gram-negative bacteria. It is bactericidal and particularly effective against multidrug-resistant gram-negative organisms. 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