{"id":"polygynax","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or burning"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Vulvovaginal discomfort"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The formulation combines neomycin sulfate, polymyxin B sulfate, and nystatin to provide broad-spectrum antimicrobial coverage against common vaginal pathogens. Neomycin and polymyxin B target bacterial cell walls and membranes, while nystatin disrupts fungal cell membranes by binding to ergosterol. This triple-agent approach addresses both bacterial and fungal vaginal infections simultaneously.","oneSentence":"POLYGYNAX is a vaginal capsule containing a combination of antibiotics and antifungal agents that eliminates pathogenic bacteria and fungi in the vaginal tract.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:29:32.458Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Vaginal infections caused by susceptible bacteria and Candida species"},{"name":"Non-specific vaginitis"}]},"trialDetails":[{"nctId":"NCT02515656","phase":"PHASE3","title":"Assessment of the Efficacy of POLYGYNAX® in the Empirical Treatment of Infectious Vaginitis","status":"COMPLETED","sponsor":"Laboratoire Innotech International","startDate":"2015-09","conditions":"Vaginitis","enrollment":661}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":11,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"POLYGYNAX®","genericName":"POLYGYNAX®","companyName":"Laboratoire Innotech International","companyId":"laboratoire-innotech-international","modality":"Small molecule","firstApprovalDate":"","aiSummary":"POLYGYNAX is a vaginal capsule containing a combination of antibiotics and antifungal agents that eliminates pathogenic bacteria and fungi in the vaginal tract. Used for Vaginal infections caused by susceptible bacteria and Candida species, Non-specific vaginitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}