{"id":"polyethylene-glycols","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Nausea"},{"rate":"10-20","effect":"Abdominal bloating"},{"rate":"5-15","effect":"Abdominal cramping"},{"rate":"5-10","effect":"Vomiting"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Polyethylene glycols (PEGs) are inert polymers that are poorly absorbed in the gastrointestinal tract. They create an osmotic gradient that pulls water into the bowel lumen, increasing stool bulk and frequency without being metabolized or causing electrolyte imbalances. This mechanism makes them effective for treating constipation and for bowel preparation prior to colonoscopy.","oneSentence":"Polyethylene glycols act as osmotic laxatives that draw water into the intestinal lumen to promote bowel movements.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:01:56.124Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Constipation"},{"name":"Bowel preparation for colonoscopy and other gastrointestinal procedures"}]},"trialDetails":[{"nctId":"NCT03914625","phase":"PHASE3","title":"A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2019-07-03","conditions":"B Acute Lymphoblastic Leukemia, B Lymphoblastic Lymphoma, Down Syndrome","enrollment":6720},{"nctId":"NCT04123795","phase":"PHASE3","title":"A Study to Evaluate the Pharmacokinetics, Safety, and Effectiveness of Certolizumab Pegol in Children With Moderate to Severe Chronic Plaque Psoriasis","status":"ACTIVE_NOT_RECRUITING","sponsor":"UCB Biopharma SRL","startDate":"2020-01-21","conditions":"Moderate Chronic Plaque Psoriasis, Severe Chronic Plaque Psoriasis, Mixed Guttate/Plaque Psoriasis","enrollment":49},{"nctId":"NCT03654170","phase":"PHASE1","title":"A Study in Healthy Men to Find Out How BI 425809 is Taken up and Handled by the Body","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2018-09-11","conditions":"Healthy","enrollment":6},{"nctId":"NCT06357897","phase":"NA","title":"The Efficacy and Palatability of Developed Polyethylene Glycol-based Formula for Children With Functional Constipation","status":"RECRUITING","sponsor":"Chulalongkorn University","startDate":"2024-05-03","conditions":"Functional Constipation","enrollment":52},{"nctId":"NCT07491913","phase":"NA","title":"Biologic Treatment Withdrawal in Takayasu Arteritis Patients in Sustained Remission","status":"RECRUITING","sponsor":"Marmara University","startDate":"2025-06-15","conditions":"Takayasu Arteritis","enrollment":40},{"nctId":"NCT06159777","phase":"PHASE4","title":"Pre-operative Polyethylene Glycol 3350 for Minimally Invasive Urogynecologic Surgery","status":"COMPLETED","sponsor":"University Hospitals Cleveland Medical Center","startDate":"2024-06-05","conditions":"Constipation, Surgical Procedure, Unspecified, Prolapse; Female","enrollment":74},{"nctId":"NCT05312970","phase":"PHASE4","title":"Varithena Versus Endothermal Ablation of the Great Saphenous Vein (VERITAS)","status":"TERMINATED","sponsor":"Boston Scientific Corporation","startDate":"2023-02-10","conditions":"Varicose Veins","enrollment":43},{"nctId":"NCT02938520","phase":"PHASE3","title":"Study to Evaluate the Efficacy, Safety, and Tolerability of Long-acting Intramuscular Cabotegravir and Rilpivirine for Maintenance of Virologic Suppression Following Switch From an Integrase Inhibitor in HIV-1 Infected Therapy Naive Participants","status":"ACTIVE_NOT_RECRUITING","sponsor":"ViiV Healthcare","startDate":"2016-10-27","conditions":"HIV Infections","enrollment":631},{"nctId":"NCT07478029","phase":"","title":"Clinical Study of PEG Bowel Preparation in Appendectomy Patients","status":"RECRUITING","sponsor":"Huaping Xie","startDate":"2024-02-23","conditions":"Appendicitis, Appendicitis Acute","enrollment":10},{"nctId":"NCT07235085","phase":"PHASE3","title":"A Study to Evaluate the Efficacy and Safety of OTX-TKI (Axitinib Implant) in Participants With Non-Proliferative Diabetic Retinopathy","status":"RECRUITING","sponsor":"Ocular Therapeutix, Inc.","startDate":"2025-11-17","conditions":"Non-Proliferative Diabetic Retinopathy","enrollment":930},{"nctId":"NCT07246902","phase":"","title":"Mobilization and Outcomes After Venous Closure","status":"RECRUITING","sponsor":"Cordis US Corp.","startDate":"2025-11-24","conditions":"Venous Vascular Closure, Electrophysiology Study","enrollment":300},{"nctId":"NCT07465705","phase":"PHASE3","title":"Clinical Trial on Bowel Preparation Comparing Mannitol 100g to Plenvu Both in a Same Day Regimen (CLEARWAY)","status":"RECRUITING","sponsor":"NTC srl","startDate":"2025-09-02","conditions":"Elective Colonoscopy","enrollment":412},{"nctId":"NCT06124157","phase":"PHASE3","title":"A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)","status":"RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2025-05-30","conditions":"B Acute Lymphoblastic Leukemia","enrollment":222},{"nctId":"NCT05172999","phase":"PHASE2, PHASE3","title":"Loxenatide Plus LNG-IUS in Endometrial Atypical Hyperplasia","status":"COMPLETED","sponsor":"Fudan University","startDate":"2022-01-08","conditions":"Atypical Endometrial Hyperplasia, Obesity, Fertility Issues","enrollment":30},{"nctId":"NCT05602194","phase":"PHASE3","title":"Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for Leukemia or Lymphoma","status":"RECRUITING","sponsor":"Children's Oncology Group","startDate":"2023-08-14","conditions":"B Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1, B Acute Lymphoblastic Leukemia, BCR-ABL1-Like","enrollment":440},{"nctId":"NCT03959085","phase":"PHASE3","title":"Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy","status":"RECRUITING","sponsor":"Children's Oncology Group","startDate":"2019-10-31","conditions":"B Acute Lymphoblastic Leukemia, B Lymphoblastic Lymphoma, Central Nervous System Leukemia","enrollment":5951},{"nctId":"NCT06520826","phase":"PHASE3","title":"Vafseo Outcomes In-Center Experience","status":"ACTIVE_NOT_RECRUITING","sponsor":"USRC Kidney Research","startDate":"2024-11-20","conditions":"Anemia of Chronic Kidney Disease","enrollment":2200},{"nctId":"NCT03932201","phase":"","title":"Evaluating Effectiveness and Long Term Safety of Damoctocog Alfa Pegol in Patients, Who Have Been Diagnosed With Hemophilia A","status":"ACTIVE_NOT_RECRUITING","sponsor":"Bayer","startDate":"2019-10-21","conditions":"Hemophilia A","enrollment":371},{"nctId":"NCT05157971","phase":"PHASE1","title":"Venetoclax and a Pediatric-Inspired Regimen for the Treatment of Newly Diagnosed B Cell Acute Lymphoblastic Leukemia","status":"RECRUITING","sponsor":"City of Hope Medical Center","startDate":"2022-03-17","conditions":"B Acute Lymphoblastic Leukemia, Ph-Like Acute Lymphoblastic Leukemia","enrollment":24},{"nctId":"NCT04789044","phase":"PHASE2","title":"Evaluating the Safety and Efficacy of Polyethylene Glycol (PEG) Mediated Fusion (PEG Fusion)","status":"RECRUITING","sponsor":"Major Extremity Trauma Research Consortium","startDate":"2023-06-01","conditions":"Peripheral Nerve Injuries","enrollment":40},{"nctId":"NCT03165734","phase":"PHASE3","title":"A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis","status":"RECRUITING","sponsor":"Swedish Orphan Biovitrum","startDate":"2017-06-26","conditions":"Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis","enrollment":399},{"nctId":"NCT07429760","phase":"NA","title":"Mechanical Bowel Preparation With or Without Oral Antibiotics in Left Sided Colorectal Cancer Surgery","status":"ENROLLING_BY_INVITATION","sponsor":"Shaukat Khanum Memorial Cancer Hospital & Research Centre","startDate":"2025-08-01","conditions":"Colorectal Cancer","enrollment":60},{"nctId":"NCT03007147","phase":"PHASE3","title":"Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia","status":"ACTIVE_NOT_RECRUITING","sponsor":"Children's Oncology Group","startDate":"2017-08-08","conditions":"Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia, Mixed Phenotype Acute Leukemia","enrollment":475},{"nctId":"NCT07426133","phase":"NA","title":"Whatsapp Based Patient Education to Improve Bowel Preparation for Colonoscopy","status":"COMPLETED","sponsor":"Shaukat Khanum Memorial Cancer Hospital & Research Centre","startDate":"2025-03-23","conditions":"Assessing Bowel Preparation Quality","enrollment":110},{"nctId":"NCT02981628","phase":"PHASE2","title":"Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or Relapsed or Refractory CD22 Positive B Acute Lymphoblastic Leukemia","status":"RECRUITING","sponsor":"Children's Oncology Group","startDate":"2017-06-19","conditions":"Recurrent B Acute Lymphoblastic Leukemia, Recurrent B Lymphoblastic Lymphoma, Refractory B Acute Lymphoblastic Leukemia","enrollment":80},{"nctId":"NCT06016387","phase":"PHASE2","title":"Tucatinib, Trastuzumab and Capecitabine With Brain and/or Spinal Radiotherapy (XRT) in Patients With HER2+, HER2 Mutated and/or HER2-amplified Metastatic Breast Cancer and Leptomeningeal Disease: A Multi-centre Phase II, Single Arm Feasibility Study","status":"RECRUITING","sponsor":"Sunnybrook Health Sciences Centre","startDate":"2023-11-25","conditions":"HER2-positive Breast Cancer, LMD","enrollment":30},{"nctId":"NCT04199026","phase":"NA","title":"Implantable Microdevice for the Delivery of Drugs and Their Effect on Tumors in Patients With Metastatic or Recurrent Sarcoma","status":"RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2025-02-25","conditions":"Metastatic Sarcoma, Recurrent Sarcoma, Resectable Sarcoma","enrollment":20},{"nctId":"NCT07260500","phase":"PHASE2","title":"A Phase II Study of PEG-rhGH Injection for Short Children Born Small for Gestational Age: Efficacy, Safety, and Pharmacokinetics","status":"RECRUITING","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2025-11-11","conditions":"Short Stature Children Born Small for Gestational Age (SGA)","enrollment":72},{"nctId":"NCT05305066","phase":"NA","title":"Stand UP to Rheumatoid Arthritis (SUPRA)","status":"RECRUITING","sponsor":"Marie Hudson, MD","startDate":"2023-02-01","conditions":"Rheumatoid Arthritis","enrollment":75},{"nctId":"NCT07370740","phase":"NA","title":"A Clinical Trial to Investigate the Safety and Efficacy of Bloat on Gas and Bloating in Healthy Women","status":"NOT_YET_RECRUITING","sponsor":"Arrae","startDate":"2026-05","conditions":"Bloating, Gastrointestinal Symptoms, Intestinal Gas","enrollment":100},{"nctId":"NCT05230758","phase":"PHASE3","title":"Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain Tumour","status":"RECRUITING","sponsor":"Donald Mabbott","startDate":"2022-07-01","conditions":"Medulloblastoma, Childhood, Cognitive Impairment","enrollment":140},{"nctId":"NCT06377956","phase":"","title":"The Associations Between Gut Length, Gut Microbiota and Food Assimilation","status":"COMPLETED","sponsor":"Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences","startDate":"2024-05-15","conditions":"Healthy Nutrition, Food Preferences, Metabolic Syndrome, Protection Against","enrollment":42},{"nctId":"NCT07218523","phase":"PHASE3","title":"A Study to Investigate Bowel Cleansing With PLENVU® Compared to Sodium Picosulfate in Participants Aged 1 to < 18 Years of Age in Preparation for Colonoscopy","status":"RECRUITING","sponsor":"Norgine","startDate":"2025-12-29","conditions":"Bowel Cleansing Prior to Clinical Procedures","enrollment":212},{"nctId":"NCT07337694","phase":"NA","title":"Exploring the Clinical Value of an AI-Assisted Patient Self-Assessment App for Bowel Preparation: A Multicenter Study","status":"NOT_YET_RECRUITING","sponsor":"Sixth Affiliated Hospital, Sun Yat-sen University","startDate":"2026-01-01","conditions":"Bowel Preparation for Colonoscopy, Colonoscopy","enrollment":524},{"nctId":"NCT02714881","phase":"","title":"Lipids, Inflammation, and CV Risk in RA","status":"COMPLETED","sponsor":"Brigham and Women's Hospital","startDate":"2016-10-17","conditions":"Rheumatoid Arthritis, Cardiovascular Disease","enrollment":74},{"nctId":"NCT07353853","phase":"NA","title":"Pre-packaged Low-residue Diet for Bowel Preparation in Patients With Inflammatory Bowel Disease","status":"RECRUITING","sponsor":"Changhai Hospital","startDate":"2026-01-01","conditions":"IBD (Inflammatory Bowel Disease), Colonoscopy, Colonoscopy: Bowel Preparation","enrollment":1000},{"nctId":"NCT07277907","phase":"PHASE3","title":"Efficacy and Safety of Lubiprostone in the Treatment of Slow Transit Constipation","status":"RECRUITING","sponsor":"Third Military Medical University","startDate":"2025-11-13","conditions":"Slow Transit Constipation, Pharmacotherapy","enrollment":346},{"nctId":"NCT07352566","phase":"PHASE4","title":"Utilization of a Microdevice for Psoriasis and Atopic Dermatitis","status":"NOT_YET_RECRUITING","sponsor":"University of California, San Francisco","startDate":"2026-01-01","conditions":"Psoriasis, Atopic Dermatitis","enrollment":10},{"nctId":"NCT04113382","phase":"PHASE1, PHASE2","title":"Study Assessing CLENPIQ as Bowel Preparation for Pediatric Colonoscopy","status":"RECRUITING","sponsor":"Ferring Pharmaceuticals","startDate":"2022-06-23","conditions":"Bowel Preparation","enrollment":30},{"nctId":"NCT07201311","phase":"PHASE2","title":"Combined Gastrointestinal Decontamination in Acute Severe Poisoning","status":"NOT_YET_RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2026-03","conditions":"Severe Poisoning With Cardiotropic or Psychotropic Drug, Admission to Intensive Care","enrollment":200},{"nctId":"NCT07335705","phase":"","title":"Analysis of Factors Influencing the Quality of Bowel Preparation Before Colonoscopy in IBD Patients","status":"RECRUITING","sponsor":"Changhai Hospital","startDate":"2025-12-08","conditions":"IBD (Inflammatory Bowel Disease), Colonoscopy, Colonoscopy: Bowel Preparation","enrollment":1000},{"nctId":"NCT06994585","phase":"NA","title":"Comparing the Bowel Cleansing Efcacy of Picosulfate Sodium/ Citric Acid / Magnesium Oxide and Polyethylene Glycol: A Randomized Trial in Taiwan","status":"COMPLETED","sponsor":"Fu Jen Catholic University Hospital","startDate":"2024-03-20","conditions":"Bowel Preparation","enrollment":440},{"nctId":"NCT07329738","phase":"NA","title":"Single-Subject Research Design on 3D-Printed Prosthetic Sockets","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of British Columbia","startDate":"2023-07-17","conditions":"Transtibial Amputees","enrollment":8},{"nctId":"NCT03808610","phase":"PHASE1, PHASE2","title":"Low-Intensity Chemotherapy and Venetoclax in Treating Patients With Relapsed or Refractory B- or T-Cell Acute Lymphoblastic Leukemia","status":"ACTIVE_NOT_RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2019-04-03","conditions":"Recurrent B Acute Lymphoblastic Leukemia, Recurrent T Acute Lymphoblastic Leukemia, Refractory B Acute Lymphoblastic Leukemia","enrollment":50},{"nctId":"NCT07328880","phase":"NA","title":"4-L Split-dose Polyethylene Glycol and Bisacodyl and Docusate Sodium Regimen Versus 2-L Split-dose Polyethylene Glycol Plus Oral Simethicone Regimen for Bowel Preparation Before Colonoscopy","status":"RECRUITING","sponsor":"Tanta University","startDate":"2025-04-01","conditions":"Colonoscopy Preparation","enrollment":450},{"nctId":"NCT01596335","phase":"PHASE3","title":"Clinical Study of TA-650 in Patients With Refractory Kawasaki Disease","status":"COMPLETED","sponsor":"Tanabe Pharma Corporation","startDate":"2012-05","conditions":"Kawasaki Disease Refractory to Initial Therapy With Intravenous Immunoglobulin","enrollment":31},{"nctId":"NCT00501826","phase":"PHASE2","title":"Combination Chemotherapy and Nelarabine in Treating Patients With T-cell Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma","status":"RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2007-07-11","conditions":"T Acute Lymphoblastic Leukemia, T Lymphoblastic Lymphoma","enrollment":160},{"nctId":"NCT07320989","phase":"NA","title":"Impact of Chewing Gum on Bowel Preparation in Patients Undergoing Colonoscopy","status":"NOT_YET_RECRUITING","sponsor":"University of Maryland, Baltimore","startDate":"2025-12-21","conditions":"Colon Cancer Screening","enrollment":100},{"nctId":"NCT05658523","phase":"PHASE3","title":"COVID-19 Booster Study in Healthy Adults in Australia","status":"ACTIVE_NOT_RECRUITING","sponsor":"Murdoch Childrens Research Institute","startDate":"2023-02-28","conditions":"COVID-19","enrollment":496},{"nctId":"NCT07072585","phase":"PHASE2, PHASE3","title":"Testing the Addition of Daratumumab to Chemotherapy for Treating Patients With Newly-Diagnosed T-Cell Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LL)","status":"NOT_YET_RECRUITING","sponsor":"Children's Oncology Group","startDate":"2026-06-28","conditions":"Stage II T Lymphoblastic Leukemia/Lymphoma, Stage III T Lymphoblastic Leukemia/Lymphoma, Stage IV T Lymphoblastic Leukemia/Lymphoma","enrollment":1708},{"nctId":"NCT02951052","phase":"PHASE3","title":"Study Evaluating the Efficacy, Safety, and Tolerability of Switching to Long-acting Cabotegravir Plus Long-acting Rilpivirine From Current Antiretroviral Regimen in Virologically Suppressed HIV-1-infected Adults","status":"ACTIVE_NOT_RECRUITING","sponsor":"ViiV Healthcare","startDate":"2016-10-28","conditions":"Infection, Human Immunodeficiency Virus, HIV Infections","enrollment":618},{"nctId":"NCT06778434","phase":"PHASE2","title":"The Effect of Topical Imipramine on Photodynamic Therapy-Mediated Immunosuppression on Forearms or Face on US Veterans","status":"RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2025-04-01","conditions":"Actinic Keratosis, Imipramine, Photodynamic Therapy","enrollment":48},{"nctId":"NCT04361656","phase":"","title":"The Effect of Adding Lubiprostone to Standard Large-Volume PEG-ELS on The Quality of Inpatient Colonoscopy Preparation","status":"WITHDRAWN","sponsor":"Henry Ford Health System","startDate":"2020-05-01","conditions":"Colonoscopy Preparation","enrollment":""},{"nctId":"NCT04745910","phase":"PHASE4","title":"Pegloticase for the Reduction of Uric Acid in Patients With Tumor Lysis Syndrome","status":"ACTIVE_NOT_RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2022-04-05","conditions":"Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm, Tumor Lysis Syndrome","enrollment":10},{"nctId":"NCT04759885","phase":"PHASE2, PHASE3","title":"Efficacy and Safety of mAnnitol in Bowel Preparation During Elective Colonoscopy and Comparison With Moviprep®","status":"COMPLETED","sponsor":"NTC srl","startDate":"2020-06-18","conditions":"Elective Colonoscopy","enrollment":886},{"nctId":"NCT03117751","phase":"PHASE2, PHASE3","title":"Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma","status":"ACTIVE_NOT_RECRUITING","sponsor":"St. Jude Children's Research Hospital","startDate":"2017-03-29","conditions":"Acute Lymphoblastic Leukemia, Acute Lymphoblastic Lymphoma","enrollment":790},{"nctId":"NCT02101853","phase":"PHASE3","title":"Blinatumomab in Treating Younger Patients With Relapsed B-cell Acute Lymphoblastic Leukemia","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2014-12-17","conditions":"Recurrent B Acute Lymphoblastic Leukemia","enrollment":669},{"nctId":"NCT02112916","phase":"PHASE3","title":"Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2014-10-04","conditions":"Adult T Acute Lymphoblastic Leukemia, Ann Arbor Stage II Adult Lymphoblastic Lymphoma, Ann Arbor Stage II Childhood Lymphoblastic Lymphoma","enrollment":847},{"nctId":"NCT02003222","phase":"PHASE3","title":"Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2014-05-19","conditions":"Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative","enrollment":488},{"nctId":"NCT02883049","phase":"PHASE3","title":"Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2012-02-29","conditions":"B Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia, BCR-ABL1-Like, Central Nervous System Leukemia","enrollment":5949},{"nctId":"NCT06132165","phase":"PHASE1","title":"Efficacy of Skin Cooling in Reducing Pain Associated With Non-invasive Treatments of Neurofibromatosis Type 1 Cutaneous Neurofibromas","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2024-03-01","conditions":"Neurofibromatosis 1","enrollment":13},{"nctId":"NCT06342830","phase":"PHASE2","title":"Comparing the Effect of Different Intracanal Dressing on Failed Root Canal Treated Cases on Periapical Healing","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2024-06-20","conditions":"Periapical Disease","enrollment":60},{"nctId":"NCT05036278","phase":"PHASE4","title":"Prophylaxis Regimen for Hemophilia A Patients","status":"COMPLETED","sponsor":"Bayer","startDate":"2022-07-28","conditions":"Hemophilia A, Prophylaxis of Bleeding","enrollment":21},{"nctId":"NCT07143370","phase":"NA","title":"Microbial Colonization in Three Dimensional (3D) Printed Orthodontic Clear Aligners","status":"COMPLETED","sponsor":"University of Michigan","startDate":"2025-09-02","conditions":"Orthodontic Aligner, Microbial Colonization","enrollment":30},{"nctId":"NCT05424757","phase":"","title":"Polyethylene Glycol Safety in Children","status":"COMPLETED","sponsor":"Children's Hospital of Philadelphia","startDate":"2022-09-30","conditions":"Polyethylene Glycols, Children, Only","enrollment":158},{"nctId":"NCT05897086","phase":"PHASE2, PHASE3","title":"Polyethylene-glycol Assisted Nerve Repair in Phalloplasty","status":"ENROLLING_BY_INVITATION","sponsor":"Vanderbilt University Medical Center","startDate":"2023-08-01","conditions":"Gender Dysphoria","enrollment":30},{"nctId":"NCT02359825","phase":"PHASE1","title":"Nerve Repair Using Hydrophilic Polymers to Promote Immediate Fusion of Severed Axons and Swift Return of Function","status":"RECRUITING","sponsor":"Vanderbilt University Medical Center","startDate":"2019-09-19","conditions":"Peripheral Nerve Injury","enrollment":18},{"nctId":"NCT04991025","phase":"PHASE2","title":"Adding Certolizumab to Chemotherapy + Nivolumab in People Who Have Lung Cancer That Can Be Treated With Surgery","status":"RECRUITING","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2022-10-19","conditions":"Lung Cancer, Lung Cancer Stage II, Lung Cancer Stage III","enrollment":60},{"nctId":"NCT06028438","phase":"PHASE2","title":"A Study to Evaluate the Nipocalimab and Certolizumab Combination Therapy in Participants With Active Rheumatoid Arthritis","status":"COMPLETED","sponsor":"Janssen Research & Development, LLC","startDate":"2023-08-15","conditions":"Arthritis, Rheumatoid","enrollment":103},{"nctId":"NCT05439772","phase":"PHASE4","title":"Examining the Effect of Ondansetron on Bowel Prep Success","status":"COMPLETED","sponsor":"State University of New York - Downstate Medical Center","startDate":"2021-01-01","conditions":"Abdominal Pain, Inflammatory Bowel Diseases, Eosinophilic Gastroenteritis","enrollment":41},{"nctId":"NCT03945825","phase":"PHASE1","title":"Flublok or Fluzone With Advax-CpG55.2 or AF03","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2019-06-10","conditions":"Influenza, Influenza Immunisation","enrollment":241},{"nctId":"NCT07216157","phase":"NA","title":"NoSeal Trial: Comparing Sealants Versus No Sealant for Preventing CSF Leak After Endonasal Skull Base Surgery","status":"RECRUITING","sponsor":"Maria Sklodowska-Curie National Research Institute of Oncology","startDate":"2025-08-15","conditions":"CerebroSpinal Fluid (CSF) Leak","enrollment":225},{"nctId":"NCT07215000","phase":"PHASE4","title":"Cleansing Options in Out-Patient Setting to Improve Tolerance (COOP SIT) Trial","status":"RECRUITING","sponsor":"Morehouse School of Medicine","startDate":"2025-10-01","conditions":"Colorectal Cancer Screening, Bowel Cleansing for Colonoscopy","enrollment":300},{"nctId":"NCT05379322","phase":"PHASE3","title":"The Use of Synovial Biopsies in Predicting Response to Biologic Therapy in Rheumatoid Arthritis Patients","status":"WITHDRAWN","sponsor":"Abu Dhabi Stem Cells Center","startDate":"2023-03-01","conditions":"Rheumatoid Arthritis","enrollment":""},{"nctId":"NCT07206329","phase":"NA","title":"PEG-Asc Vs. SPMC for Bowel Preparation in Capsule-based Procedures","status":"COMPLETED","sponsor":"Unidade Local de Saúde do Alto Ave, EPE","startDate":"2024-01-01","conditions":"Bowel Preparation Solution","enrollment":220},{"nctId":"NCT04501614","phase":"PHASE1, PHASE2","title":"A Study of Ponatinib With Chemotherapy in Children, Teenagers, and Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia","status":"TERMINATED","sponsor":"Takeda","startDate":"2021-02-24","conditions":"Pediatric Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia (Ph+ALL), Ph+ Mixed Phenotype Acute Leukemia (MPAL), Philadelphia Chromosome-Like ALL (Ph-like ALL)","enrollment":11},{"nctId":"NCT05042440","phase":"PHASE1","title":"Pharmacokinetic Assessment of Standard Half-Life (SHL) FVIII, Extended Half-Life (EHL) FVIII, and Efanesoctocog Alfa (BIVV001) in Severe Hemophilia A","status":"COMPLETED","sponsor":"Sanofi","startDate":"2021-08-11","conditions":"Hemophilia A","enrollment":13},{"nctId":"NCT05088408","phase":"NA","title":"Comparative Study Between Colonoscopy Bowel Preparation With Clear Liquids, With and Without Two Servings of High Energy Nutritional Supplement","status":"COMPLETED","sponsor":"Clínica de Gastroenterologia","startDate":"2020-10-30","conditions":"Colonoscopy, Bowel Preparation","enrollment":299},{"nctId":"NCT07145827","phase":"NA","title":"Effect of Metformin on Endometrial Thickness in Postmenopausal Breast Cancer Patients Receiving Tamoxifen","status":"COMPLETED","sponsor":"Uruk University","startDate":"2024-01-02","conditions":"Breast Cancer, Endometrial Hyperplasia and Endometrial Cancers","enrollment":60},{"nctId":"NCT00661388","phase":"PHASE3","title":"A Study of Monthly Subcutaneous Mircera for the Treatment of Chronic Renal Anemia in Predialysis Patients Not Treated With ESA.","status":"COMPLETED","sponsor":"Hoffmann-La Roche","startDate":"2008-08","conditions":"Anemia","enrollment":75},{"nctId":"NCT06514989","phase":"NA","title":"Efficacy of Low-residue Full Nutritive Formula Powder in Bowel Preparation for Colonoscopy","status":"COMPLETED","sponsor":"Changhai Hospital","startDate":"2024-07-01","conditions":"Bowel Preparation for Colonoscopy","enrollment":757},{"nctId":"NCT00560404","phase":"PHASE3","title":"A Study of Subcutaneous Mircera for the Maintenance Treatment of Dialysis Patients With Chronic Renal Anemia.","status":"COMPLETED","sponsor":"Hoffmann-La Roche","startDate":"2008-04","conditions":"Anemia","enrollment":233},{"nctId":"NCT04546399","phase":"PHASE2","title":"A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)","status":"RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2020-12-17","conditions":"Down Syndrome, Recurrent B Acute Lymphoblastic Leukemia","enrollment":461},{"nctId":"NCT06037473","phase":"","title":"The Efficacy and Safety of PEGylated GH for the Treatment of Short Stature in Chinese Children-GLOBE Reg","status":"RECRUITING","sponsor":"Beijing Children's Hospital","startDate":"2023-08-01","conditions":"Growth Hormone Treatment, Growth Disorders","enrollment":2600},{"nctId":"NCT07144488","phase":"NA","title":"The Impact of Olive Oil Polyphenol Supplementation on Metabolic Syndrome Parameters: Preclinical Investigations Have Demonstrated That Olive Oil Polyphenols, Notably Oleocanthal, Oleacein, and Allied Secoiridoids, Possess Anti-inflammatory and Antioxidant Attributes","status":"COMPLETED","sponsor":"Apostolos Loukas Medical Centre Cyprus","startDate":"2024-09-01","conditions":"Metabolic Syndrome","enrollment":106},{"nctId":"NCT05117996","phase":"NA","title":"Simplified Bowel Preparation Versus Standard Bowel Preparation Before Capsule Endoscopy in Patients With Crohn's Disease","status":"COMPLETED","sponsor":"Nantes University Hospital","startDate":"2022-07-05","conditions":"Crohn Disease","enrollment":144},{"nctId":"NCT04474002","phase":"PHASE4","title":"Efficacy, Tolerance and Safety of Split Dose Bowel Preparation for Colonoscopy: 4L Polyethylene Glycol (PEG) Versus 1L Polyethylene Glycol Plus Sodium Picosulfate-magnesium Citrate (SPMC)","status":"COMPLETED","sponsor":"Queen Elizabeth Hospital, Hong Kong","startDate":"2020-12-07","conditions":"Bowel Preparation Solutions, Colonoscopy","enrollment":158},{"nctId":"NCT06867822","phase":"PHASE1","title":"Trial of ProAgio in Advanced/Metastatic Colorectal Cancer","status":"RECRUITING","sponsor":"University of Alabama at Birmingham","startDate":"2025-07-17","conditions":"Advanced Colorectal Cancer, Metastatic Colorectal Cancer","enrollment":27},{"nctId":"NCT07138898","phase":"PHASE2","title":"Immunosuppressant Management in Rheumatology Patients Undergoing Elective Total Shoulder Arthroplasty","status":"NOT_YET_RECRUITING","sponsor":"NYU Langone Health","startDate":"2025-09","conditions":"Rheumatic Disease","enrollment":80},{"nctId":"NCT04263896","phase":"PHASE4","title":"Bowel Function After Minimally Invasive Hysterectomy","status":"COMPLETED","sponsor":"University of Chicago","startDate":"2019-08-28","conditions":"Constipation","enrollment":97},{"nctId":"NCT03255694","phase":"PHASE2","title":"A Study Extension Period of PEG-somatropin (Pegylated-somatropin) in the Treatment of Children With Idiopathic Short Stature","status":"ACTIVE_NOT_RECRUITING","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2017-05-12","conditions":"Dwarfism","enrollment":360},{"nctId":"NCT07084350","phase":"NA","title":"Combination of Lactulose and Polyethylene Glycol Electrolytes Powder (PEG-ELS) for Bowel Preparation in Type II Diabetes Mellitus Patients","status":"NOT_YET_RECRUITING","sponsor":"General Hospital of Shenyang Military Region","startDate":"2025-08-25","conditions":"Type II Diabetes Mellitus","enrollment":254},{"nctId":"NCT07120490","phase":"NA","title":"STOP-CDI: Efficacy of Fecal Microbiota Transplantation vs Fidaxomicin vs Vancomycin in Treating and Preventing Relapse of Clostridioides Difficile Infection","status":"NOT_YET_RECRUITING","sponsor":"Medical University of Warsaw","startDate":"2025-10","conditions":"Clostridioides Difficile Infection, Clostridioides Difficile Infection Recurrence, Fecal Microbiota Transplantation (FMT)","enrollment":424},{"nctId":"NCT04997733","phase":"PHASE3","title":"Fecal Microbiota Transplantation in Crohn's Disease as Relay After Anti-TNF Withdrawal","status":"RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2021-09-22","conditions":"Crohn Disease","enrollment":150},{"nctId":"NCT03414502","phase":"PHASE3","title":"Treatment of Rheumatoid Arthritis With DMARDs: Predictors of Response","status":"RECRUITING","sponsor":"University of Nebraska","startDate":"2007-12-10","conditions":"Rheumatoid Arthritis","enrollment":400},{"nctId":"NCT06797505","phase":"PHASE1","title":"A Bioequivalence Study of Two Different PEG-rhGH Preparations","status":"COMPLETED","sponsor":"Changchun GeneScience Pharmaceutical Co., Ltd.","startDate":"2025-02-10","conditions":"Pediatric Growth Hormone Deficiency (PGHD)","enrollment":87},{"nctId":"NCT07109128","phase":"NA","title":"The T1D Talks Pilot Study","status":"ENROLLING_BY_INVITATION","sponsor":"Western Michigan University School of Medicine","startDate":"2024-02-15","conditions":"Type 1 Diabetes (T1D)","enrollment":18},{"nctId":"NCT06506136","phase":"PHASE1, PHASE2","title":"Evaluation of Fluoxetine for Refractory Constipation With Somatic Symptom Disorder Features","status":"NOT_YET_RECRUITING","sponsor":"Zhifeng Zhao, PhD","startDate":"2025-09-01","conditions":"Refractory Constipation, Somatic Symptom Disorder (DSM-5), Functional Constipation (FC)","enrollment":194},{"nctId":"NCT05660473","phase":"PHASE2","title":"Pediatric-inspired Regimen Combined With Venetoclax for Adolescent and Adult Patients With de Novo Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia","status":"RECRUITING","sponsor":"Institute of Hematology & Blood Diseases Hospital, China","startDate":"2022-08-01","conditions":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","enrollment":100},{"nctId":"NCT06455813","phase":"PHASE4","title":"What Laxative Should be Used After Hip Fracture Surgery?","status":"RECRUITING","sponsor":"Odense University Hospital","startDate":"2024-10-07","conditions":"Hip Fractures","enrollment":375}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":994,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["glycerin enema","asol","Miralax","Coolprep®; Taejoon Pharmaceuticals, Seoul, Korea"],"phase":"marketed","status":"active","brandName":"Polyethylene Glycols","genericName":"Polyethylene Glycols","companyName":"Tomas Bata Hospital, Czech Republic","companyId":"tomas-bata-hospital-czech-republic","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Polyethylene glycols act as osmotic laxatives that draw water into the intestinal lumen to promote bowel movements. Used for Constipation, Bowel preparation for colonoscopy and other gastrointestinal procedures.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":3,"withResults":2},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}