{"id":"polyethylene-glycol-electrolytes","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Nausea"},{"rate":"10-20","effect":"Abdominal bloating or distension"},{"rate":"5-15","effect":"Abdominal cramping"},{"rate":"5-10","effect":"Vomiting"},{"rate":"5-10","effect":"Anal irritation"}]},"_chembl":{"chemblId":"CHEMBL1201478","moleculeType":"Small molecule"},"_dailymed":{"setId":"3978822b-6473-4072-9f80-20ceb9bea355","title":"GAVILYTE G TM (POLYETHYLENE GLYCOL-3350 AND ELECTROLYTES) POWDER, FOR SOLUTION [LUPIN PHARMACEUTICALS,INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The polyethylene glycol (PEG) polymer is poorly absorbed and creates an osmotic gradient that retains water in the intestinal lumen. The added electrolytes (typically sodium chloride, potassium chloride, sodium bicarbonate, and sodium sulfate) maintain electrolyte balance and prevent net absorption or secretion of electrolytes, ensuring isotonic conditions. This combination promotes bowel cleansing by increasing stool bulk and facilitating passage without significant fluid or electrolyte shifts.","oneSentence":"Polyethylene glycol with electrolytes acts as an osmotic laxative that draws water into the bowel lumen to promote bowel evacuation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T02:05:20.642Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bowel cleansing prior to colonoscopy or other gastrointestinal procedures"},{"name":"Constipation management"}]},"trialDetails":[{"nctId":"NCT07478029","phase":"","title":"Clinical Study of PEG Bowel Preparation in Appendectomy Patients","status":"RECRUITING","sponsor":"Huaping Xie","startDate":"2024-02-23","conditions":"Appendicitis, Appendicitis Acute","enrollment":10},{"nctId":"NCT06377956","phase":"","title":"The Associations Between Gut Length, Gut Microbiota and Food Assimilation","status":"COMPLETED","sponsor":"Shenzhen Institutes of Advanced 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