{"id":"polyethylene-glycol-based-lavage","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Abdominal discomfort"},{"rate":null,"effect":"Bloating"},{"rate":null,"effect":"Dehydration"}]},"_chembl":{"chemblId":"CHEMBL1201478","moleculeType":"Small molecule"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This bowel preparation agent works through osmotic action, where polyethylene glycol (PEG) and electrolytes draw water into the intestinal lumen, creating a fluid environment that facilitates the movement and elimination of stool. The solution is non-absorbable and passes through the gastrointestinal tract largely unchanged, effectively cleansing the colon without significant systemic absorption. This mechanism makes it suitable for pre-procedure bowel preparation prior to colonoscopy or other diagnostic/therapeutic procedures.","oneSentence":"Polyethylene glycol-based lavage solution mechanically cleanses and prepares the colon by osmotically drawing fluid into the bowel lumen to promote evacuation of fecal matter.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:29:29.473Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bowel preparation prior to colonoscopy"},{"name":"Bowel preparation prior to other gastrointestinal procedures"}]},"trialDetails":[{"nctId":"NCT06342830","phase":"PHASE2","title":"Comparing the Effect of Different Intracanal Dressing on Failed Root Canal Treated Cases on Periapical Healing","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2024-06-20","conditions":"Periapical Disease","enrollment":60},{"nctId":"NCT05570318","phase":"NA","title":"Effect of MiniGo As Add-on to Oral Laxatives for Children with Constipation and Fecal Incontinence","status":"COMPLETED","sponsor":"University of Aarhus","startDate":"2022-11-01","conditions":"Functional Constipation, Fecal Incontinence in Children","enrollment":50},{"nctId":"NCT04977479","phase":"PHASE2","title":"The Safety of Administering a Second Dose of a COVID-19 mRNA Vaccine in Individuals Who Experienced a Systemic Allergic Reaction to an Initial Dose","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2021-09-08","conditions":"Systemic Allergic Reaction","enrollment":20},{"nctId":"NCT04479423","phase":"NA","title":"The Usage of Soda-Water in Gastric Preparation for Magnetically Controlled Capsule Endoscopy","status":"COMPLETED","sponsor":"Changhai Hospital","startDate":"2020-12-03","conditions":"Gastric Disease, Capsule Endoscopy","enrollment":252},{"nctId":"NCT02466698","phase":"PHASE2, PHASE3","title":"Intestinal Lavage for the Treatment of Severe C. Difficile Infections","status":"UNKNOWN","sponsor":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","startDate":"2016-08","conditions":"Clostridium Difficile","enrollment":20},{"nctId":"NCT01778192","phase":"PHASE3","title":"A Randomized Prospective Trial Comparing Polyethylene Glycol and Sodium Picosulphate With Magnesium Citrate","status":"COMPLETED","sponsor":"Korea University Anam Hospital","startDate":"2012-07","conditions":"Colorectal Cancer, Colon Adenoma","enrollment":200},{"nctId":"NCT01610856","phase":"NA","title":"Single Dose Versus Split Dose Polyethylene Glycol-based Colonic Lavage for Colonoscopy","status":"COMPLETED","sponsor":"University of Calgary","startDate":"2010-03","conditions":"Colonoscopy Preparation","enrollment":250},{"nctId":"NCT01610895","phase":"NA","title":"Split Dose Polyethylene Glycol (PEG) + Clear Fluids Versus Split Dose PEG + Low-Residue Diet","status":"UNKNOWN","sponsor":"University of Calgary","startDate":"2011-12","conditions":"Colorectal Cancer","enrollment":345},{"nctId":"NCT01415687","phase":"PHASE3","title":"Split Dose Pico-Salax + Bisacodyl vs. PEG Split Dose","status":"COMPLETED","sponsor":"University of Calgary","startDate":"2011-05","conditions":"Bowel Preparation for Colonoscopy","enrollment":171}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":12,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Colyte"],"phase":"phase_3","status":"active","brandName":"Polyethylene Glycol-Based Lavage","genericName":"Polyethylene Glycol-Based Lavage","companyName":"University of Calgary","companyId":"university-of-calgary","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Polyethylene Glycol (PEG) is used as an osmotic laxative in intestinal lavage for various conditions, including Clostridium Difficile infections, functional constipation, and bowel preparation for colonoscopy. PEG is a small molecule that works by increasing water in the intestines to stimulate bowel movements.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}