{"id":"polyethylene-glycol-ascorbate","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Nausea"},{"rate":"15-25","effect":"Abdominal discomfort or cramping"},{"rate":"5-10","effect":"Vomiting"},{"rate":"10-20","effect":"Bloating"},{"rate":"5-15","effect":"Headache"}]},"_chembl":null,"_fixedAt":"2026-03-30T12:51:20.813837","_dailymed":{"setId":"8ff46193-2a3b-4de0-9572-775dda8cd8b2","title":"MOVIPREP (POLYETHYLENE GLYCOL 3350, SODIUM SULFATE, SODIUM CHLORIDE, POTASSIUM CHLORIDE, ASCORBIC ACID, SODIUM ASCORBATE) KIT [SALIX PHARMACEUTICALS, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Polyethylene glycol (PEG) is a non-absorbable osmotic agent that retains water in the colon, promoting bowel evacuation. Ascorbate (vitamin C) is added to enhance the cleansing effect and reduce the volume of solution needed. Together, they facilitate rapid intestinal transit and thorough bowel preparation without significant systemic absorption.","oneSentence":"Polyethylene glycol with ascorbate acts as an osmotic laxative that draws water into the intestinal lumen while ascorbate enhances bowel cleansing efficacy.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:01:47.802Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bowel cleansing prior to colonoscopy or other gastrointestinal procedures"}]},"_fixedFields":["pubmed(12)"],"trialDetails":[{"nctId":"NCT07320989","phase":"NA","title":"Impact of Chewing Gum on Bowel Preparation in Patients Undergoing Colonoscopy","status":"NOT_YET_RECRUITING","sponsor":"University of Maryland, Baltimore","startDate":"2025-12-21","conditions":"Colon Cancer Screening","enrollment":100},{"nctId":"NCT04759885","phase":"PHASE2, PHASE3","title":"Efficacy and Safety of mAnnitol in Bowel Preparation During Elective Colonoscopy and Comparison With Moviprep®","status":"COMPLETED","sponsor":"NTC srl","startDate":"2020-06-18","conditions":"Elective Colonoscopy","enrollment":886},{"nctId":"NCT07206329","phase":"NA","title":"PEG-Asc Vs. SPMC for Bowel Preparation in Capsule-based Procedures","status":"COMPLETED","sponsor":"Unidade Local de Saúde do Alto Ave, EPE","startDate":"2024-01-01","conditions":"Bowel Preparation Solution","enrollment":220},{"nctId":"NCT05242562","phase":"NA","title":"Effect of Low-volume (1L) vs Intermediate-volume (2L) Bowel Preparation on Cost-effectiveness and Quality of Life","status":"COMPLETED","sponsor":"Radboud University Medical Center","startDate":"2022-05-16","conditions":"Colorectal Cancer, Colonic Polyp","enrollment":509},{"nctId":"NCT05436054","phase":"PHASE4","title":"A Trial to Compare Efficacy and Tolerability of Plenvu® and Picoprep® as Cleansing Agents Before Colonoscopy","status":"RECRUITING","sponsor":"Aalborg University Hospital","startDate":"2022-10-01","conditions":"Colon Disease","enrollment":400},{"nctId":"NCT04297423","phase":"PHASE4","title":"Two Low Volume Regimens for Colorectal Cancer Screening Colonoscopy","status":"COMPLETED","sponsor":"Hospital Clinic of Barcelona","startDate":"2020-03-11","conditions":"Colorectal Cancer","enrollment":1002},{"nctId":"NCT04970173","phase":"","title":"1L-PEG-Asc Solution for Bowel Preparation in an \"Open Access\" Colonoscopy Booking System: Evaluation of Adverse Events","status":"COMPLETED","sponsor":"Azienda USL Modena","startDate":"2019-01-01","conditions":"Bowel Preparation","enrollment":5981},{"nctId":"NCT05249335","phase":"PHASE4","title":"Comparison for Efficacy and Safety of Bowel Preparation Between Oral Sulfate Table and 2L-polyethylene Glycol/Ascorbate in Elderly","status":"UNKNOWN","sponsor":"Pharmbio Korea Co., Ltd.","startDate":"2022-02","conditions":"Colonic Disease, Intestinal Disease","enrollment":256},{"nctId":"NCT04708366","phase":"PHASE4","title":"Colon Cleansing Efficacy With 1L vs. 2L vs. 4L-PEG for Colonoscopy Among Inpatients","status":"UNKNOWN","sponsor":"University of Bologna","startDate":"2021-02-01","conditions":"Colon Disease","enrollment":846},{"nctId":"NCT04598880","phase":"PHASE4","title":"Comparison of 1 Liter PEG With Ascorbate and Sodium Picosulfate / Magnesium Citrate for High Quality Colon Cleansing","status":"UNKNOWN","sponsor":"Parc de Salut Mar","startDate":"2020-11-06","conditions":"Colonic Diseases","enrollment":1104},{"nctId":"NCT02956057","phase":"PHASE4","title":"Polyethylene Glycol Versus Low Volume Solutions Prior to Colonoscopy","status":"COMPLETED","sponsor":"Tomas Bata Hospital, Czech Republic","startDate":"2016-11-12","conditions":"Colonoscopy","enrollment":1044},{"nctId":"NCT03742232","phase":"PHASE4","title":"Study Comparing the Bowel Cleansing Efficacy of PLENVU® Versus SELG-ESSE® Using a 2-Day Split Dosing Regimen.","status":"COMPLETED","sponsor":"Istituto Clinico Humanitas","startDate":"2018-10-31","conditions":"Colon Polyp, Colon Adenoma, Colon Lesion","enrollment":399},{"nctId":"NCT04225793","phase":"NA","title":"The Use of Osmotic Laxatives Versus Macrogol for Bowel Preparation in Patients Undergoing Colonoscopy","status":"UNKNOWN","sponsor":"Russian Society of Colorectal Surgeons","startDate":"2019-06-02","conditions":"Colorectal Disorders","enrollment":98},{"nctId":"NCT03698474","phase":"PHASE4","title":"Comparison of Different Low Volume Solutions Prior to Colonoscopy","status":"COMPLETED","sponsor":"Tomas Bata Hospital, Czech Republic","startDate":"2018-10-25","conditions":"Colonoscopy","enrollment":612},{"nctId":"NCT02540031","phase":"PHASE3","title":"The Impact of Additional Oral Preparation on the Quality of Bowel Preparation for Colonoscopy","status":"COMPLETED","sponsor":"Kyungpook National University Hospital","startDate":"2015-09","conditions":"Bowel Preparation Quality","enrollment":156},{"nctId":"NCT03520361","phase":"PHASE4","title":"Comparison Between OSS and 2L PEG/Asc for Bowel Preparation of Elderly People","status":"UNKNOWN","sponsor":"KangWon National University Hospital","startDate":"2017-11-02","conditions":"Colonoscopy","enrollment":198},{"nctId":"NCT02297399","phase":"PHASE3","title":"Improvement of Tolerance of Bowel Cleansing Before Colonoscopy in Diabetic Patients","status":"COMPLETED","sponsor":"Parc de Salut Mar","startDate":"2014-12-02","conditions":"Diabetes Mellitus, Colonic Diseases","enrollment":158},{"nctId":"NCT01774175","phase":"","title":"Comparison Between Coolprep and Picolyte for Bowel Cleansing","status":"UNKNOWN","sponsor":"Gachon University Gil Medical Center","startDate":"2013-01","conditions":"Stasis; 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Used for Bowel cleansing prior to colonoscopy or other gastrointestinal procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}