{"id":"polyethelene-glycol","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Nausea"},{"rate":"10-25","effect":"Abdominal bloating or distension"},{"rate":"5-20","effect":"Abdominal cramping"},{"rate":"5-15","effect":"Vomiting"},{"rate":"5-10","effect":"Diarrhea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"PEG is a non-absorbable polymer that creates an osmotic gradient in the gastrointestinal tract, increasing intraluminal fluid volume and promoting intestinal motility. This mechanism facilitates stool passage without being systemically absorbed, making it suitable for bowel preparation and constipation relief.","oneSentence":"Polyethylene glycol (PEG) is an osmotic laxative that draws water into the intestinal lumen to soften stool and promote bowel movements.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:01:46.834Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bowel preparation prior to colonoscopy or other GI procedures"},{"name":"Constipation management"}]},"trialDetails":[{"nctId":"NCT06349031","phase":"PHASE4","title":"Comparison of Efficacy & Tolerability Of PEG 4000 Versus PEG 3350+ Electrolytes for Pediatric Fecal Disimpaction","status":"NOT_YET_RECRUITING","sponsor":"Institute of Medical Sciences and SUM Hospital","startDate":"2024-04-15","conditions":"Functional Constipation, Fecal Impaction, Constipation - Functional","enrollment":100},{"nctId":"NCT04504292","phase":"NA","title":"Pilot Study to Assess Tolerability and Feasibility of Oral Sulfate Solution (SUPREP) in Hospitalized Patients","status":"UNKNOWN","sponsor":"University of Virginia","startDate":"2020-08-01","conditions":"Inpatient Colonoscopy, Oral Sulfate Solution, Polyethelene Glycol","enrollment":124},{"nctId":"NCT01627171","phase":"PHASE4","title":"Colonoscopy Preparation Optimization for INpatients- COIN Study","status":"UNKNOWN","sponsor":"St. Joseph's Healthcare Hamilton","startDate":"2012-09","conditions":"Endoscopy, Bowel Preparation Solutions","enrollment":126}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":29,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["PEG-Lyte"],"phase":"marketed","status":"active","brandName":"Polyethelene Glycol","genericName":"Polyethelene Glycol","companyName":"St. Joseph's Healthcare Hamilton","companyId":"st-joseph-s-healthcare-hamilton","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Polyethylene glycol (PEG) is an osmotic laxative that draws water into the intestinal lumen to soften stool and promote bowel movements. Used for Bowel preparation prior to colonoscopy or other GI procedures, Constipation management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}