{"id":"polidocanol-with-glucose","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or burning"},{"rate":null,"effect":"Thrombophlebitis"},{"rate":null,"effect":"Hyperpigmentation at injection site"},{"rate":null,"effect":"Allergic reactions"},{"rate":null,"effect":"Necrosis (rare)"}]},"_chembl":{"chemblId":"CHEMBL6067961","moleculeType":"Small molecule"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Polidocanol is a non-ionic surfactant that damages the endothelial lining of blood vessels, triggering an inflammatory response that leads to vessel wall fibrosis and obliteration. When combined with glucose, the formulation enhances the sclerosing effect and improves the density and visibility of the solution for injection into varicose veins and telangiectasias. This causes the targeted vessels to collapse and be reabsorbed by the body.","oneSentence":"Polidocanol is a sclerosing agent that causes endothelial damage and fibrosis of blood vessel walls, used in combination with glucose as a sclerosant for varicose veins and other vascular lesions.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:01:45.415Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Varicose veins"},{"name":"Telangiectasia and spider veins"},{"name":"Venous malformations"}]},"trialDetails":[{"nctId":"NCT07073742","phase":"PHASE2","title":"CLaCS Using 0.2% Aetoxysklerol Foam and 70% Glucose for the Treatment of Lower Limb Telangiectasias","status":"NOT_YET_RECRUITING","sponsor":"Charles University, Czech Republic","startDate":"2025-09-01","conditions":"Varicose Veins of Lower Limb, Spider Veins, Reticular Leg Veins","enrollment":240},{"nctId":"NCT05860439","phase":"","title":"Lower Limb Sclerotherapy of Reticular Veins and Telangiectasias","status":"COMPLETED","sponsor":"UPECLIN HC FM Botucatu Unesp","startDate":"2017-01-01","conditions":"Telangiectasis","enrollment":191},{"nctId":"NCT04846361","phase":"NA","title":"Vaginal Hygiene Wash as Adjunct Treatment in Bacterial Vaginosis","status":"UNKNOWN","sponsor":"Universiti Kebangsaan Malaysia Medical Centre","startDate":"2021-05","conditions":"Bacterial Vaginoses","enrollment":56},{"nctId":"NCT02657252","phase":"PHASE4","title":"Polidocanol Versus Glucose Treatment of Telangiectasia Trial","status":"COMPLETED","sponsor":"UPECLIN HC FM Botucatu Unesp","startDate":"2015-01","conditions":"Varicose Veins, Telangiectasis","enrollment":115},{"nctId":"NCT02054325","phase":"PHASE4","title":"Study Protocol Comparing Polidocanol Versus Hypertonic Glucose for Treatment of Reticular Veins","status":"COMPLETED","sponsor":"UPECLIN HC FM Botucatu Unesp","startDate":"2012-09","conditions":"Varicose Veins","enrollment":106}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Dodecylpolyethyleneglycolether","Aethoxysklerol","Varithena","Asclera"],"phase":"marketed","status":"active","brandName":"Polidocanol with Glucose","genericName":"Polidocanol with Glucose","companyName":"UPECLIN HC FM Botucatu Unesp","companyId":"upeclin-hc-fm-botucatu-unesp","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Polidocanol is a sclerosing agent that causes endothelial damage and fibrosis of blood vessel walls, used in combination with glucose as a sclerosant for varicose veins and other vascular lesions. Used for Varicose veins, Telangiectasia and spider veins, Venous malformations.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}