{"id":"pneumosil","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site erythema"},{"rate":null,"effect":"Injection site swelling"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Irritability"},{"rate":null,"effect":"Drowsiness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The vaccine contains capsular polysaccharides from 13 serotypes of S. pneumoniae conjugated to a diphtheria toxoid carrier protein. This conjugation enhances T-cell dependent immune responses, promoting both antibody production and cellular immunity against pneumococcal infection. The vaccine is designed to provide protection against invasive pneumococcal disease and pneumococcal pneumonia across multiple serotypes.","oneSentence":"PNEUMOSIL is a pneumococcal conjugate vaccine that stimulates immune responses against Streptococcus pneumoniae by presenting polysaccharide antigens conjugated to a protein carrier.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:29:29.139Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of invasive pneumococcal disease in infants and children"},{"name":"Prevention of pneumococcal pneumonia"}]},"trialDetails":[{"nctId":"NCT06817421","phase":"PHASE4","title":"Opportunistic Pneumococcal Immunisation Trial in MALnutrition","status":"NOT_YET_RECRUITING","sponsor":"Nick Fancourt","startDate":"2026-01","conditions":"Severe Acute Malnutrition in Childhood, Pneumococcal Disease, Pneumococcal Vaccines","enrollment":214},{"nctId":"NCT03896477","phase":"PHASE3","title":"Study of 10-valent Pneumococcal Conjugate Vaccine (Pneumosil) Administered in a 2+1 Schedule to Healthy Infants","status":"COMPLETED","sponsor":"PATH","startDate":"2019-07-18","conditions":"Pneumonia, Pneumococcal","enrollment":660},{"nctId":"NCT05140720","phase":"NA","title":"Assess the Safety and Immunogenicity of PNEUMOSIL® Vaccine in Healthy Vietnamese Children, 6 Weeks to 24 Months of Age","status":"UNKNOWN","sponsor":"Vabiotech","startDate":"2022-01-25","conditions":"Streptococcus Pneumonia, Vaccine Preventable Disease","enrollment":300}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":12,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Serum Institute of India Pneumococcal conjugate vaccine (SIIPL-PCV )"],"phase":"phase_3","status":"active","brandName":"PNEUMOSIL®","genericName":"PNEUMOSIL®","companyName":"Vabiotech","companyId":"vabiotech","modality":"Biologic","firstApprovalDate":"","aiSummary":"PNEUMOSIL is a pneumococcal conjugate vaccine that stimulates immune responses against Streptococcus pneumoniae by presenting polysaccharide antigens conjugated to a protein carrier. Used for Prevention of invasive pneumococcal disease in infants and children, Prevention of pneumococcal pneumonia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}