{"id":"pneumococcal-7-valent-conjugate-vaccine","safety":{"commonSideEffects":[{"rate":"10–50%","effect":"Local injection site reactions (erythema, swelling, induration)"},{"rate":"10–15%","effect":"Fever"},{"rate":"5–10%","effect":"Irritability or fussiness"},{"rate":"5–10%","effect":"Drowsiness"},{"rate":"5–10%","effect":"Decreased appetite"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The vaccine contains purified capsular polysaccharides from 7 serotypes of pneumococcus conjugated to diphtheria toxoid protein. This conjugation enhances immunogenicity by converting T-cell-independent antigens into T-cell-dependent antigens, enabling robust antibody responses and immunological memory. The resulting antibodies opsonize pneumococcal bacteria, facilitating complement activation and phagocytic clearance.","oneSentence":"This vaccine stimulates the immune system to produce antibodies against 7 serotypes of Streptococcus pneumoniae by presenting pneumococcal polysaccharide antigens conjugated to a protein carrier.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:29:24.457Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of invasive pneumococcal disease in infants and young children"},{"name":"Prevention of pneumococcal otitis media and pneumonia in pediatric populations"}]},"trialDetails":[{"nctId":"NCT07242092","phase":"PHASE4","title":"Influence of Methotrexate Discontinuation on Immunogenicity After PCV-20 Vaccine in Patients ARDs","status":"NOT_YET_RECRUITING","sponsor":"University of Sao Paulo General Hospital","startDate":"2026-03-25","conditions":"Autoimmune Rheumatic Diseases","enrollment":192},{"nctId":"NCT07300267","phase":"PHASE1","title":"A Clinical Study of Novel Pneumococcal Vaccine V118C in Children (V118C-002)","status":"RECRUITING","sponsor":"Merck Sharp & Dohme LLC","startDate":"2026-01-13","conditions":"Pneumococcal Infection","enrollment":210},{"nctId":"NCT04460313","phase":"NA","title":"Nasopharyngeal Carriage of S. 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