{"id":"plaunotol","rwe":[{"pmid":"35812138","year":"2022","title":"Preparation, characterization, and antibacterial activity of plaunotol and plaunoi extracts complexed with hydroxypropyl-β-cyclodextrin.","finding":"","journal":"Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society","studyType":"Clinical Study"},{"pmid":"26300313","year":"2015","title":"Functional expression of a putative geraniol 8-hydroxylase by reconstitution of bacterially expressed plant CYP76F45 and NADPH-cytochrome P450 reductase CPR I from Croton stellatopilosus Ohba.","finding":"","journal":"Phytochemistry","studyType":"Clinical Study"},{"pmid":"25443840","year":"2014","title":"Molecular cloning, bacterial expression and functional characterisation of cytochrome P450 monooxygenase, CYP97C27, and NADPH-cytochrome P450 reductase, CPR I, from Croton stellatopilosus Ohba.","finding":"","journal":"Plant science : an international journal of experimental plant biology","studyType":"Clinical Study"},{"pmid":"24286075","year":"2013","title":"Acute and chronic oral toxicity of a partially purified plaunotol extract from Croton stellatopilosus Ohba.","finding":"","journal":"BioMed research international","studyType":"Clinical Study"},{"pmid":"23092673","year":"2013","title":"Molecular cloning and catalytic activity of a membrane-bound prenyl diphosphate phosphatase from Croton stellatopilosus Ohba.","finding":"","journal":"Phytochemistry","studyType":"Clinical Study"}],"tags":[{"label":"plaunotol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Anti-Ulcer Agents","category":"pharmacology"},{"label":"Gastrointestinal Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"kelnac","offLabel":[],"synonyms":["plaunotol","kelnac"],"timeline":[],"approvals":[],"brandName":"Kelnac","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"plaunotol","explanation":"Unfortunately, the exact mechanism of action of Kelnac is not well understood, but it is thought to involve a complex series of interactions with cellular components to produce its desired outcome. This process is not yet fully elucidated, and further research is needed to clarify its effects on the body. As a result, patients should consult with their healthcare provider for more information on how Kelnac works and its potential benefits and risks.","oneSentence":"Kelnac works by interacting with a specific target in the body to produce its therapeutic effect.","technicalDetail":"Kelnac's mechanism of action is not well characterized, but it is believed to involve binding to a specific receptor or enzyme to produce its therapeutic effect. The exact molecular details of this process are not yet fully understood and require further investigation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2222","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=PLAUNOTOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:21:48.741280","biosimilars":[],"competitors":[],"genericName":"plaunotol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"MV715X4634","CHEBI":"CHEBI:32023","INN_ID":"5323","UMLSCUI":"C0071276","ChEMBL_ID":"CHEMBL285815","KEGG_DRUG":"D01803","PUBCHEM_CID":"5282197","MESH_SUPPLEMENTAL_RECORD_UI":"C047686"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":67,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2022 Jun","pmid":"35812138","title":"Preparation, characterization, and antibacterial activity of plaunotol and plaunoi extracts complexed with hydroxypropyl-β-cyclodextrin.","journal":"Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society"},{"date":"2015 Oct","pmid":"26300313","title":"Functional expression of a putative geraniol 8-hydroxylase by reconstitution of bacterially expressed plant CYP76F45 and NADPH-cytochrome P450 reductase CPR I from Croton stellatopilosus Ohba.","journal":"Phytochemistry"},{"date":"2014 Dec","pmid":"25443840","title":"Molecular cloning, bacterial expression and functional characterisation of cytochrome P450 monooxygenase, CYP97C27, and NADPH-cytochrome P450 reductase, CPR I, from Croton stellatopilosus Ohba.","journal":"Plant science : an international journal of experimental plant biology"},{"date":"2013","pmid":"24286075","title":"Acute and chronic oral toxicity of a partially purified plaunotol extract from Croton stellatopilosus Ohba.","journal":"BioMed research international"},{"date":"2013 Jul","pmid":"23092673","title":"Molecular cloning and catalytic activity of a membrane-bound prenyl diphosphate phosphatase from Croton stellatopilosus Ohba.","journal":"Phytochemistry"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Kelnac is a small molecule medication. It is also known by the synonym PLAUNOTOL.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}