{"id":"platelet-rich-fibrin-matrix-kit","safety":{"commonSideEffects":[{"rate":null,"effect":"Infection at application site"},{"rate":null,"effect":"Delayed healing"},{"rate":null,"effect":"Allergic reaction (rare, autologous source)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"PRFM is prepared from the patient's own blood and processed to create a fibrin matrix enriched with platelets and growth factors (PDGF, VEGF, FGF, TGF-β). When applied to surgical or wound sites, the matrix acts as a scaffold for cell migration and differentiation while delivering bioactive molecules that stimulate angiogenesis, collagen deposition, and tissue remodeling.","oneSentence":"Platelet Rich Fibrin Matrix (PRFM) concentrates autologous platelets and fibrin to promote tissue regeneration and wound healing through growth factor release.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:51:49.029Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Periodontal bone regeneration and defect filling"},{"name":"Alveolar bone augmentation in dental implantology"},{"name":"Soft tissue wound healing and guided tissue regeneration"}]},"trialDetails":[{"nctId":"NCT07183631","phase":"PHASE4","title":"Healing of Intrabony Defects Following Treatment With PRF or EMD","status":"COMPLETED","sponsor":"Semmelweis University","startDate":"2021-09-01","conditions":"Periodontal Bone Loss, Periodontal Disease, Platelet Rich Fibrin","enrollment":28},{"nctId":"NCT05572242","phase":"NA","title":"Leukocyte-platelet Rich Fibrin for Alveolar Ridge Preservation","status":"UNKNOWN","sponsor":"Universidad de los Andes, Chile","startDate":"2022-11-01","conditions":"Alveolar Ridge Enlargement","enrollment":38},{"nctId":"NCT03616925","phase":"PHASE3","title":"Evaluation of Platelet Rich Fibrin Matrix as Regenerative Material in Intraosseous Defects","status":"COMPLETED","sponsor":"KLE Society's Institute of Dental Sciences","startDate":"2013-09","conditions":"Regenerative Inflammation","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["centrifugation machine"],"phase":"phase_3","status":"active","brandName":"Platelet Rich Fibrin Matrix kit","genericName":"Platelet Rich Fibrin Matrix kit","companyName":"KLE Society's Institute of Dental Sciences","companyId":"kle-society-s-institute-of-dental-sciences","modality":"Biologic","firstApprovalDate":"","aiSummary":"Platelet Rich Fibrin Matrix (PRFM) concentrates autologous platelets and fibrin to promote tissue regeneration and wound healing through growth factor release. Used for Periodontal bone regeneration and defect filling, Alveolar bone augmentation in dental implantology, Soft tissue wound healing and guided tissue regeneration.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}