{"id":"placebo-with-0-09-menthol-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation"},{"rate":null,"effect":"Burning or stinging at application site"},{"rate":null,"effect":"Erythema"}]},"_chembl":{"chemblId":"CHEMBL256087","moleculeType":"Small molecule","molecularWeight":"156.27"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Menthol is a naturally occurring compound that binds to transient receptor potential melastatin 8 (TRPM8) channels, creating a cooling sensation and potentially modulating pain perception at the application site. This topical effect may provide symptomatic relief through counter-irritation and desensitization of nociceptors. The placebo formulation serves as a control in clinical trials to assess the true efficacy of menthol versus inert vehicle.","oneSentence":"Menthol provides topical cooling and mild analgesic sensation through activation of TRPM8 cold-sensitive receptors on the skin.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:29:09.815Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical pain relief (likely musculoskeletal or localized pain indication in Phase 3 trial)"}]},"trialDetails":[{"nctId":"NCT02100670","phase":"PHASE3","title":"A Multicenter Efficacy Study of a Diclofenac+Menthol Gel in Subjects With Ankle Sprain","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2013-11-01","conditions":"Pain","enrollment":385}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Placebo with 0.09% menthol gel","genericName":"Placebo with 0.09% menthol gel","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Menthol provides topical cooling and mild analgesic sensation through activation of TRPM8 cold-sensitive receptors on the skin. Used for Topical pain relief (likely musculoskeletal or localized pain indication in Phase 3 trial).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}