{"id":"placebo-torasemide","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Hyperuricemia"},{"rate":null,"effect":"Ototoxicity (at high doses)"},{"rate":null,"effect":"Dehydration"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Hyperglycemia"}]},"_chembl":{"chemblId":"CHEMBL1148","moleculeType":"Small molecule","molecularWeight":"348.43"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Torasemide blocks the Na-K-2Cl cotransporter in the thick ascending limb of the loop of Henle, preventing reabsorption of sodium, potassium, and chloride ions. This leads to increased urine output and reduced fluid volume in the body, lowering blood pressure and reducing edema. The placebo component serves as a control in this formulation.","oneSentence":"Torasemide is a loop diuretic that inhibits sodium and chloride reabsorption in the ascending limb of the loop of Henle, promoting urinary fluid and electrolyte excretion.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:01:28.063Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Edema associated with congestive heart failure"},{"name":"Hypertension"},{"name":"Edema associated with renal disease or hepatic cirrhosis"}]},"trialDetails":[{"nctId":"NCT06206512","phase":"PHASE2","title":"Effect of Extended Release Torsemide in Patients With Congestive Heart Failure and Overactive Bladder","status":"COMPLETED","sponsor":"Sarfez Pharmaceuticals, Inc.","startDate":"2024-06-15","conditions":"Heart Failure, Overactive Bladder, Incontinence","enrollment":24},{"nctId":"NCT06708611","phase":"PHASE4","title":"A Crossover Study of Patients with HF to Compare Natriuretic Effects of IR Torsemide Vs. ER Torsemide Over 12 Hrs","status":"TERMINATED","sponsor":"Sarfez Pharmaceuticals, Inc.","startDate":"2025-01-15","conditions":"Heart Failure","enrollment":5},{"nctId":"NCT06176794","phase":"PHASE2","title":"Immediate Release Torsemide Versus Extended Release Torsemide After Salty Meal","status":"TERMINATED","sponsor":"Sarfez Pharmaceuticals, Inc.","startDate":"2024-11-15","conditions":"Heart Failure","enrollment":1},{"nctId":"NCT06275763","phase":"PHASE4","title":"Optimal Medical Treatment of Difficult-to-treat Hypertension","status":"UNKNOWN","sponsor":"National Institute of Cardiology, Warsaw, Poland","startDate":"2023-10-20","conditions":"Hypertension","enrollment":2500},{"nctId":"NCT02813551","phase":"PHASE2","title":"ToRsemide for pOstpartum HYpertension","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2016-08","conditions":"Preeclampsia","enrollment":118},{"nctId":"NCT02644616","phase":"PHASE4","title":"The Safety and Efficacy of Tolvaptan for Patients With Tricuspid Regurgitation and Right Heart Failure After Left Heart Valves Replacement","status":"COMPLETED","sponsor":"Shanghai Chest Hospital","startDate":"2014-11","conditions":"Tricuspid Regurgitation, Right Heart Failure","enrollment":40},{"nctId":"NCT01663662","phase":"PHASE4","title":"The Use of Tolvaptan to Prevent Renal Dysfunction in High Risk Patients With Heart Failure-Pilot Study","status":"WITHDRAWN","sponsor":"University of Michigan","startDate":"2012-08","conditions":"Heart Failure","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"placebo+torasemide","genericName":"placebo+torasemide","companyName":"Shanghai Chest Hospital","companyId":"shanghai-chest-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Torasemide is a loop diuretic that inhibits sodium and chloride reabsorption in the ascending limb of the loop of Henle, promoting urinary fluid and electrolyte excretion. Used for Edema associated with congestive heart failure, Hypertension, Edema associated with renal disease or hepatic cirrhosis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}