{"id":"placebo-to-ondansetron","safety":{"commonSideEffects":[{"rate":"9-27%","effect":"Headache"},{"rate":"5-25%","effect":"Constipation"},{"rate":"3-15%","effect":"Diarrhea"},{"rate":"5-13%","effect":"Fatigue"},{"rate":"4-7%","effect":"Dizziness"},{"rate":"2-8%","effect":"Fever"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ondansetron selectively antagonizes 5-hydroxytryptamine (serotonin) at the 5-HT3 receptor, which is located on vagal afferent nerves in the gastrointestinal tract and in the chemoreceptor trigger zone of the brain. By blocking these receptors, it prevents the transmission of emetic signals that would otherwise trigger the vomiting center, making it highly effective for chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV).","oneSentence":"Ondansetron is a selective 5-HT3 receptor antagonist that blocks serotonin signaling in the chemoreceptor trigger zone and gastrointestinal tract to prevent nausea and vomiting.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:51:46.152Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chemotherapy-induced nausea and vomiting (CINV)"},{"name":"Postoperative nausea and vomiting (PONV)"},{"name":"Radiation-induced nausea and vomiting"}]},"trialDetails":[{"nctId":"NCT07498751","phase":"PHASE1","title":"Phase I PK and Safety Study of Ondansetron Inhalation Powder","status":"COMPLETED","sponsor":"Luxena Pharmaceuticals, Inc.","startDate":"2025-03-13","conditions":"Postoperative Nausea 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