{"id":"placebo-plus-corticosteroid","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Oral thrush"},{"rate":"10-20%","effect":"Weight gain"},{"rate":"5-10%","effect":"Insomnia"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL780","moleculeType":"Small molecule","molecularWeight":"393.35"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Corticosteroids work by binding to glucocorticoid receptors in cells, which then translocate to the nucleus and alter gene expression to reduce inflammation. This results in decreased production of pro-inflammatory cytokines and increased production of anti-inflammatory cytokines.","oneSentence":"Corticosteroids are anti-inflammatory agents that reduce inflammation by suppressing the immune system's response.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:51:38.601Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Asthma"},{"name":"Chronic obstructive pulmonary disease (COPD)"}]},"trialDetails":[{"nctId":"NCT06033196","phase":"PHASE2","title":"Tocilizumab in Lung Transplantation","status":"RECRUITING","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2024-02-13","conditions":"Lung Transplant","enrollment":350},{"nctId":"NCT06339008","phase":"PHASE3","title":"A Study of Lebrikizumab in Adult Participants With Perennial Allergic Rhinitis (PREPARED-1)","status":"RECRUITING","sponsor":"Eli Lilly and Company","startDate":"2024-04-26","conditions":"Perennial Allergic Rhinitis (PAR)","enrollment":450},{"nctId":"NCT06338995","phase":"PHASE3","title":"A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP)","status":"RECRUITING","sponsor":"Eli Lilly and Company","startDate":"2024-04-29","conditions":"Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)","enrollment":510},{"nctId":"NCT05935332","phase":"PHASE2","title":"Phase 2 Study to Evaluate RPT193 in Adults With Moderate to Severe T2-high Asthma","status":"TERMINATED","sponsor":"RAPT Therapeutics, Inc.","startDate":"2023-07-05","conditions":"Asthma","enrollment":38},{"nctId":"NCT06934915","phase":"EARLY_PHASE1","title":"Prednisone in Adults With an Immune-Mediated Subtype of Autism Spectrum Disorder","status":"NOT_YET_RECRUITING","sponsor":"Christopher John McDougle, M.D.","startDate":"2026-11","conditions":"Autism Spectrum Disorder, Autism Spectrum Disorders, Autistic Disorder","enrollment":32},{"nctId":"NCT03663335","phase":"PHASE2","title":"Study of Efficacy, Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) of an Anti-CD40 Monoclonal Antibody, CFZ533, in Kidney Transplant Recipients","status":"COMPLETED","sponsor":"Novartis Pharmaceuticals","startDate":"2018-11-28","conditions":"Kidney Transplantation","enrollment":418},{"nctId":"NCT07255248","phase":"PHASE4","title":"Hoffa's Fat Pad Impingement (HFPI)","status":"RECRUITING","sponsor":"Boston Children's Hospital","startDate":"2026-03-01","conditions":"Hoffa's Fat Pad Impingement","enrollment":62},{"nctId":"NCT06311682","phase":"PHASE3","title":"A Trial to Evaluate the Efficacy and Safety of Tralokinumab in Combination With Topical Corticosteroids in Children and Infants With Moderate-to-severe Atopic Dermatitis","status":"RECRUITING","sponsor":"LEO Pharma","startDate":"2024-06-10","conditions":"Atopic Dermatitis","enrollment":195},{"nctId":"NCT05268289","phase":"PHASE2","title":"Study of Efficacy and Safety of LNP023 in Participants With Active Lupus Nephritis Class III-IV, +/- V","status":"RECRUITING","sponsor":"Novartis Pharmaceuticals","startDate":"2022-08-10","conditions":"Lupus Nephritis","enrollment":240},{"nctId":"NCT06750289","phase":"PHASE3","title":"Randomised Clinical Trial to Investigate Efficacy and Safety of Benralizumab 30 mg SC as an add-on Therapy in Uncontrolled Eosinophilic Asthma Patients Treated With Medium-dose ICS-LABA Compared to Conventional Escalation to High-dose ICS-LABA Treatment","status":"RECRUITING","sponsor":"AstraZeneca","startDate":"2025-03-28","conditions":"Eosinophilic Asthma","enrollment":400},{"nctId":"NCT07073950","phase":"PHASE4","title":"A Study to Investigate the Effect of Budesonide/Glycopyrronium/Formoterol Fumarate Metered Dose Inhaler (BGF MDI) Compared With Placebo MDI on Heart and Lung Function in Participants With Chronic Obstructive Pulmonary Disease (COPD) and Hyperinflation","status":"RECRUITING","sponsor":"AstraZeneca","startDate":"2025-11-24","conditions":"Chronic Obstructive Pulmonary Disease, Hyperinflation","enrollment":56},{"nctId":"NCT01577082","phase":"PHASE3","title":"Efficacy and Safety of CHF 1535 200/6µg in Not Adequately Controlled Asthmatic Patients","status":"COMPLETED","sponsor":"Chiesi Farmaceutici S.p.A.","startDate":"2012-04-20","conditions":"Asthma","enrollment":542},{"nctId":"NCT06795893","phase":"","title":"The Anifrolumab PRIM Program","status":"RECRUITING","sponsor":"AstraZeneca","startDate":"2025-11-07","conditions":"Systemic Lupus Erythematosus","enrollment":240},{"nctId":"NCT07190196","phase":"PHASE3","title":"A 52-week Study of Rilzabrutinib Efficacy and Safety Compared to Placebo in Adults Diagnosed With IgG4-related Disease","status":"RECRUITING","sponsor":"Sanofi","startDate":"2025-09-26","conditions":"Immunoglobulin G4 Related Disease","enrollment":124},{"nctId":"NCT06659029","phase":"","title":"Prospective Registry Investigating Maternal and Infant Outcomes in Anifrolumab Users","status":"RECRUITING","sponsor":"AstraZeneca","startDate":"2025-07-01","conditions":"Systemic Lupus Erythematosus","enrollment":442},{"nctId":"NCT05435781","phase":"PHASE4","title":"Effect of Supplemental Hydrocortisone During Stress in Prednisolone-induced Adrenal Insufficiency","status":"RECRUITING","sponsor":"Marianne Christina Klose","startDate":"2022-06-07","conditions":"Adrenal Insufficiency, Polymyalgia Rheumatica, Giant Cell Arteritis","enrollment":250},{"nctId":"NCT05811351","phase":"PHASE2","title":"A Study to Evaluate Intravitreal JNJ-81201887 (AAVCAGsCD59) Compared to Sham Procedure for the Treatment of Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)","status":"COMPLETED","sponsor":"Janssen Research & Development, LLC","startDate":"2023-03-06","conditions":"Geographic Atrophy","enrollment":305},{"nctId":"NCT05379634","phase":"PHASE2","title":"A Study of Nipocalimab in Participants With Active Idiopathic Inflammatory Myopathies","status":"ACTIVE_NOT_RECRUITING","sponsor":"Janssen Research & Development, LLC","startDate":"2022-07-05","conditions":"Myositis","enrollment":36},{"nctId":"NCT03953300","phase":"PHASE4","title":"Benralizumab Airway Remodeling Study in Severe Eosinophilic Asthmatics","status":"ACTIVE_NOT_RECRUITING","sponsor":"AstraZeneca","startDate":"2019-10-08","conditions":"Asthma","enrollment":75},{"nctId":"NCT05986318","phase":"PHASE2","title":"Reducing Respiratory Symptoms of Pulmonary Irradiation in Interstitial Lung Disease","status":"RECRUITING","sponsor":"David Palma","startDate":"2025-01-07","conditions":"Lung Cancer, Interstitial Lung Disease","enrollment":98},{"nctId":"NCT05039619","phase":"PHASE2","title":"A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants","status":"RECRUITING","sponsor":"Hoffmann-La Roche","startDate":"2022-05-12","conditions":"Lupus Nephritis","enrollment":40},{"nctId":"NCT04206553","phase":"PHASE2, PHASE3","title":"A Study to Evaluate the Efficacy and Safety of Dupilumab in Adult Patients With Bullous Pemphigoid","status":"COMPLETED","sponsor":"Regeneron Pharmaceuticals","startDate":"2020-10-28","conditions":"Bullous Pemphigoid","enrollment":106},{"nctId":"NCT07450638","phase":"NA","title":"Effect of Preoperative Long-Acting Corticosteroids on Pain, Swelling, and Trismus After Impacted Lower Third Molar Surgery","status":"ACTIVE_NOT_RECRUITING","sponsor":"Al Salam University","startDate":"2026-01-04","conditions":"Impacted Mandibular Third Molar, Postoperative Pain, Trismus","enrollment":60},{"nctId":"NCT06932263","phase":"PHASE2","title":"Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adults With Uncontrolled Asthma on Medium-to-High Dose Inhaled Corticosteroids","status":"RECRUITING","sponsor":"AstraZeneca","startDate":"2025-03-26","conditions":"Asthma","enrollment":540},{"nctId":"NCT06594068","phase":"PHASE4","title":"Prospective Registry Investigating Maternal, Infant, and Lactation Outcomes in Anifrolumab Users","status":"RECRUITING","sponsor":"AstraZeneca","startDate":"2026-01-16","conditions":"Systemic Lupus Erythematosus","enrollment":16},{"nctId":"NCT06076304","phase":"PHASE4","title":"Nasal Steroids, Irrigation, Oral Antibiotics, and Subgroup Targeting for Effective Management of Acute Sinusitis","status":"RECRUITING","sponsor":"Daniel Merenstein","startDate":"2023-11-21","conditions":"Sinus Infection, Acute Sinusitis","enrollment":3720},{"nctId":"NCT06556277","phase":"NA","title":"Acute Consequences of Glucocorticoid Secretion in Overweight and Obese Individuals During Maximum Calorie Intake","status":"COMPLETED","sponsor":"Eleonora Seelig","startDate":"2024-09-01","conditions":"Glucocorticoids, Overweight and Obesity, Overeating","enrollment":23},{"nctId":"NCT07416916","phase":"PHASE4","title":"Ultrasound-Guided Intra-Articular vs Gluteal Intramuscular Corticosteroid Injection for Frozen Shoulder","status":"RECRUITING","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2026-02-23","conditions":"Frozen Shoulder","enrollment":528},{"nctId":"NCT07431775","phase":"","title":"Saphnelo Use in Females of Child-bearing Potential","status":"NOT_YET_RECRUITING","sponsor":"AstraZeneca","startDate":"2026-10-01","conditions":"Systemic Lupus Erythematosus","enrollment":26000000},{"nctId":"NCT05653349","phase":"PHASE3","title":"Study of Ianalumab Versus Placebo in Addition to First-line Corticosteroids in Primary Immune Thrombocytopenia (ITP)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Novartis Pharmaceuticals","startDate":"2023-02-03","conditions":"Primary Immune Thrombocytopenia (ITP)","enrollment":226},{"nctId":"NCT03725202","phase":"PHASE3","title":"A Study to Evaluate the Safety and Efficacy of Upadacitinib in Participants With Giant Cell Arteritis","status":"COMPLETED","sponsor":"AbbVie","startDate":"2019-01-24","conditions":"Giant Cell Arteritis (GCA)","enrollment":429},{"nctId":"NCT06701331","phase":"PHASE3","title":"Safety and Efficacy of Upadacitinib in Combination With Topical Corticosteroids in Children From 2 to Less Than 12 Years of Age in Japan With Moderate to Severe Atopic Dermatitis","status":"ACTIVE_NOT_RECRUITING","sponsor":"AbbVie","startDate":"2024-12-22","conditions":"Atopic Dermatitis","enrollment":99},{"nctId":"NCT00699751","phase":"PHASE3","title":"A Phase III Study of Radium-223 Dichloride in Patients With Symptomatic Hormone Refractory Prostate Cancer With Skeletal Metastases","status":"COMPLETED","sponsor":"Bayer","startDate":"2008-06-12","conditions":"Hormone Refractory Prostate Cancer, Bone Metastases","enrollment":921},{"nctId":"NCT07281014","phase":"PHASE4","title":"Unmitigated Aldosterone Signaling During Standard Clinical MRA Dosing","status":"RECRUITING","sponsor":"Yale University","startDate":"2026-01-27","conditions":"Heart Failure","enrollment":20},{"nctId":"NCT05888350","phase":"NA","title":"Biomarkers for Predicting the Response to Inhaled Corticosteroid in Patients With Chronic Cough.","status":"COMPLETED","sponsor":"The First Affiliated Hospital of Guangzhou Medical University","startDate":"2023-04-01","conditions":"Cough","enrollment":502},{"nctId":"NCT04161898","phase":"PHASE3","title":"A Study to Evaluate the Efficacy and Safety of Upadacitinib in Participants With Takayasu Arteritis (TAK)","status":"ACTIVE_NOT_RECRUITING","sponsor":"AbbVie","startDate":"2020-02-04","conditions":"Takayasu Arteritis (TAK)","enrollment":56},{"nctId":"NCT06241118","phase":"PHASE3","title":"A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab on Background Topical Corticosteroids Therapy in Participants Aged 12 Years and Older With Moderate-to-severe AD Who Have Had an Inadequate Response to Prior Biologic Therapy or an Oral JAK Inhibitor","status":"RECRUITING","sponsor":"Sanofi","startDate":"2024-02-29","conditions":"Dermatitis Atopic","enrollment":390},{"nctId":"NCT05345171","phase":"PHASE3","title":"Clinical Study of DTX301 AAV-Mediated Gene Transfer for Ornithine Transcarbamylase (OTC) Deficiency","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ultragenyx Pharmaceutical Inc","startDate":"2022-10-18","conditions":"OTC Deficiency","enrollment":32},{"nctId":"NCT07399717","phase":"NA","title":"Assessing Role of Probiotics in Children Aged 6-36 Months Treated for Pneumonia","status":"NOT_YET_RECRUITING","sponsor":"Anabio R&D","startDate":"2026-01-26","conditions":"Pneumonia, Pneumonia in Children","enrollment":330},{"nctId":"NCT06084364","phase":"PHASE4","title":"Intraarticular Steroids, Saline and Occupational Therapy in People With CMC1 Osteoarthritis","status":"RECRUITING","sponsor":"Diakonhjemmet Hospital","startDate":"2023-11-03","conditions":"Osteoarthritis Thumb","enrollment":354},{"nctId":"NCT04918147","phase":"PHASE2","title":"Elotuzumab in Immunoglobulin G4-Related Disease (IgG4-RD)","status":"TERMINATED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2021-10-13","conditions":"IgG4 Related Disease, IgG4-RD","enrollment":8},{"nctId":"NCT04844814","phase":"PHASE2","title":"Anakinra vs Prednisone to Treat Gout Flare in Patients With Chronic Kidney Disease Stage 4/5 or Renal Transplantation","status":"SUSPENDED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2022-06-02","conditions":"Gout, Chronic Kidney Disease, Renal Transplantation","enrollment":204},{"nctId":"NCT06283550","phase":"PHASE2","title":"Efficacy, Safety, and Tolerability of Abrocitinib in Subjects With Moderate to Severe Chronic Hand Eczema Refractory to Corticosteroid Therapy","status":"COMPLETED","sponsor":"Innovaderm Research Inc.","startDate":"2024-05-31","conditions":"Chronic Hand Eczema","enrollment":82},{"nctId":"NCT07223580","phase":"PHASE4","title":"A Study Of Corticosteroid On Postoperative Pain After Ureteroscopy For Urinary Calculi","status":"RECRUITING","sponsor":"Mayo Clinic","startDate":"2026-01-23","conditions":"Ureteroscopy, Post Operative Pain","enrollment":90},{"nctId":"NCT06572228","phase":"PHASE4","title":"Efficacy of Dupilumab Added to Medium Dose Inhaled Corticosteroid/Long-acting Beta-agonist (ICS/LABA) in Comparison to ICS Dose Escalation to High Dose ICS/LABA in Adolescent and Adult Patients With Uncontrolled Asthma","status":"RECRUITING","sponsor":"Regeneron Pharmaceuticals","startDate":"2024-08-26","conditions":"Asthma","enrollment":250},{"nctId":"NCT04157348","phase":"PHASE3","title":"Efficacy and Safety of Benralizumab in EGPA Compared to Mepolizumab.","status":"ACTIVE_NOT_RECRUITING","sponsor":"AstraZeneca","startDate":"2019-10-29","conditions":"Eosinophilic Granulomatous Vasculitis","enrollment":140},{"nctId":"NCT07380152","phase":"PHASE1","title":"Corticosteroid Therapy in Pulmonary Sequelae of Covid-19","status":"COMPLETED","sponsor":"University of Sao Paulo","startDate":"2021-08-10","conditions":"COVID-19 Pulmonary Complications","enrollment":100},{"nctId":"NCT07258771","phase":"PHASE4","title":"Upadacitinib Combined With Corticosteroids vs Corticosteroid Monotherapy Induction for Inpatients and Outpatients With Acute Severe Ulcerative Colitis","status":"RECRUITING","sponsor":"Berinstein, Jeffrey","startDate":"2026-01-16","conditions":"Ulcerative Colitis Acute","enrollment":110},{"nctId":"NCT06865170","phase":"PHASE4","title":"Pain Perception During Intra-Articular Knee Joint Injection: What is the Effect of Needle Gauge and the Use of Ethyl Chloride?","status":"NOT_YET_RECRUITING","sponsor":"University of California, Davis","startDate":"2026-05","conditions":"Osteoarthritis (OA) of the Knee, Fear of Needles","enrollment":88},{"nctId":"NCT07377058","phase":"NA","title":"RCT of Tocilizumab for Anti-MDA5+DM","status":"RECRUITING","sponsor":"Peking Union Medical College Hospital","startDate":"2025-11-01","conditions":"Dermatomyositis","enrollment":110},{"nctId":"NCT06213649","phase":"PHASE3","title":"Parasitic Ulcer Treatment Trial","status":"RECRUITING","sponsor":"Jeremy Keenan, MD, MPH","startDate":"2024-07-01","conditions":"Acanthamoeba Keratitis","enrollment":232},{"nctId":"NCT04851964","phase":"PHASE3","title":"Efficacy and Safety of Tezepelumab in Participants With Severe Chronic Rhinosinusitis With Nasal Polyposis","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2021-04-22","conditions":"Chronic Rhinosinusitis With Nasal Polyps","enrollment":416},{"nctId":"NCT05220319","phase":"PHASE4","title":"CORTERAS STUDY: The Effect of Corticosteroids on Early Recovery After Major Surgery in Elderly Patients","status":"COMPLETED","sponsor":"Ziekenhuis Oost-Limburg","startDate":"2022-02-16","conditions":"Inflammatory Response, Weakness, Muscle","enrollment":751},{"nctId":"NCT03505905","phase":"PHASE1, PHASE2","title":"A Neurosteroid Intervention for Menopausal and Perimenopausal Depression","status":"COMPLETED","sponsor":"University of Texas Southwestern Medical Center","startDate":"2018-09-01","conditions":"Major Depressive Disorder, Menopause, Perimenopause","enrollment":73},{"nctId":"NCT04859764","phase":"NA","title":"Effect of Reparel Knee Sleeve With Knee Injection","status":"COMPLETED","sponsor":"University of Alabama at Birmingham","startDate":"2022-06-29","conditions":"Osteoarthritis, Knee","enrollment":40},{"nctId":"NCT05559359","phase":"PHASE3","title":"A Study of Lebrikizumab (LY3650150) in Participants 6 Months to <18 Years of Age With Moderate-to-Severe Atopic Dermatitis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Eli Lilly and Company","startDate":"2022-10-18","conditions":"Atopic Dermatitis, Eczema","enrollment":367},{"nctId":"NCT07353749","phase":"PHASE4","title":"Efficacy and Safety of Methylprednisolone After Flow-Diverter Stent Implantation in Unruptured Intracranial Aneurysms","status":"NOT_YET_RECRUITING","sponsor":"Duan Chuanzhi","startDate":"2026-01-30","conditions":"Unruptured Intracranial Aneurysms, Cerebrovascular Event, Hemorrhagic Stroke","enrollment":864},{"nctId":"NCT06956482","phase":"PHASE3","title":"PROlonged Corticosteroid Treatment or N-ACetylcysteine for Severe Alcoholic Hepatitis","status":"NOT_YET_RECRUITING","sponsor":"University Hospital, Lille","startDate":"2026-02","conditions":"Alcoholic Hepatitis","enrollment":477},{"nctId":"NCT05704738","phase":"PHASE3","title":"A Study to Evaluate Rocatinlimab (AMG 451) in Adolescent Participants With Moderate-to-severe Atopic Dermatitis (AD)","status":"COMPLETED","sponsor":"Amgen","startDate":"2023-04-20","conditions":"Atopic Dermatitis","enrollment":532},{"nctId":"NCT02807103","phase":"PHASE3","title":"Rituximab in Eosinophilic Granulomatosis With Polyangiitis","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2016-12-05","conditions":"Eosinophilic Granulomatosis With Polyangiitis (EGPA)","enrollment":107},{"nctId":"NCT06521762","phase":"PHASE2","title":"Etrasimod for Immune Checkpoint Inhibitor Diarrhea and Colitis","status":"WITHDRAWN","sponsor":"Yale University","startDate":"2026-01","conditions":"Immune Checkpoint Inhibitor-Related Diarrhea and Colitis","enrollment":""},{"nctId":"NCT07273006","phase":"PHASE4","title":"Percutaneous Electrical Nerve Stimulation As Alternative To Nerve Blocks In Anesthesia, Pain Medicine And Rehabilitation Of Nonspecific Chronic Pain","status":"NOT_YET_RECRUITING","sponsor":"Universidad Complutense de Madrid","startDate":"2026-09-01","conditions":"Non-specific Low Back Pain (NSLBP), Facet Joint Syndrome","enrollment":82},{"nctId":"NCT03621553","phase":"PHASE4","title":"Vitamin D Homeostasis in Sarcoidosis","status":"RECRUITING","sponsor":"University of Texas Southwestern Medical Center","startDate":"2010-07-01","conditions":"Sarcoidosis, Vitamin D Insufficiency","enrollment":90},{"nctId":"NCT04231708","phase":"PHASE2","title":"Effects of Pharmacological Stress and rTMS on Executive Function in Opioid Use Disorder","status":"NOT_YET_RECRUITING","sponsor":"Wayne State University","startDate":"2026-10","conditions":"Opioid Use Disorder","enrollment":20},{"nctId":"NCT00097474","phase":"PHASE2","title":"Effects of Hydrocortisone, Melatonin, and Placebo on Jet Lag","status":"COMPLETED","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2004-12-21","conditions":"Jet Lag","enrollment":57},{"nctId":"NCT03568318","phase":"PHASE3","title":"A Study to Evaluate Upadacitinib in Combination With Topical Corticosteroids in Adolescent and Adult Participants With Moderate to Severe Atopic Dermatitis","status":"ACTIVE_NOT_RECRUITING","sponsor":"AbbVie","startDate":"2018-08-09","conditions":"Atopic Dermatitis","enrollment":1533},{"nctId":"NCT05193396","phase":"PHASE4","title":"Hydrocortisone and Placebo in Patients With Symptoms of Adrenal Insufficiency After Cessation of Glucocorticoid Treatment","status":"RECRUITING","sponsor":"Marianne Andersen","startDate":"2022-02-01","conditions":"Adrenal Insufficiency, Polymyalgia Rheumatica (PMR), Giant Cell Arteritis (GCA)","enrollment":100},{"nctId":"NCT02517489","phase":"PHASE3","title":"Community-Acquired Pneumonia : Evaluation of Corticosteroids","status":"COMPLETED","sponsor":"University Hospital, Tours","startDate":"2015-10-28","conditions":"Community Acquired Pneumonia","enrollment":952},{"nctId":"NCT00446953","phase":"PHASE4","title":"Caesarean and Corticotherapy","status":"COMPLETED","sponsor":"University Hospital, Strasbourg, France","startDate":"2007-02","conditions":"Neonatal Distress","enrollment":200},{"nctId":"NCT06029595","phase":"PHASE2","title":"Efficacy and Safety of Tanimilast in Asthmatics uNcontrolled on ICS-containinG backgrOund Maintenance Therapy","status":"TERMINATED","sponsor":"Chiesi Farmaceutici S.p.A.","startDate":"2023-11-26","conditions":"Uncontrolled Asthma","enrollment":517},{"nctId":"NCT07279688","phase":"PHASE3","title":"Justification And Evaluation of Baricitinib Plus Corticosteroids Versus corticosteroiDs Alone in pOlymyalgia RhEumatica","status":"NOT_YET_RECRUITING","sponsor":"University Hospital, Brest","startDate":"2025-12-12","conditions":"Polymyalgia Rheumatica (PMR)","enrollment":140},{"nctId":"NCT05643638","phase":"PHASE2","title":"A Study of CYP-001 in Combination With Corticosteroids in Adults With High-risk aGvHD","status":"RECRUITING","sponsor":"Cynata Therapeutics Limited","startDate":"2024-03-04","conditions":"Graft Versus Host Disease, Acute","enrollment":60},{"nctId":"NCT06527235","phase":"PHASE3","title":"Meniscal INfiltration of Corticosteroid Guided With Ultra Sonography","status":"RECRUITING","sponsor":"University Hospital, Toulouse","startDate":"2025-03-06","conditions":"Meniscus Lesion","enrollment":152},{"nctId":"NCT06224348","phase":"PHASE3","title":"A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab in Participants Aged 12 Years and Older With Moderate-to-severe Atopic Dermatitis on Background Topical Corticosteroids","status":"COMPLETED","sponsor":"Sanofi","startDate":"2024-01-18","conditions":"Dermatitis Atopic","enrollment":643},{"nctId":"NCT07174167","phase":"NA","title":"Genicular Nerve Block in Chronic Knee Osteoarthritis","status":"COMPLETED","sponsor":"Haydarpasa Numune Training and Research Hospital","startDate":"2023-04-01","conditions":"Gonarthrosis; Primary, Genicular Nerve Block, Gonarthritis","enrollment":81},{"nctId":"NCT02997605","phase":"PHASE4","title":"Comparison of Two Strategies of Glucocorticoid Withdrawal in Rheumatoid Arthritis Patients","status":"COMPLETED","sponsor":"University Hospital, Toulouse","startDate":"2017-01-31","conditions":"RheumatoId Arthritis","enrollment":102},{"nctId":"NCT03760003","phase":"PHASE2","title":"Dose-Ranging Phase 2b Study of ABX464 in Moderate to Severe Ulcerative Colitis","status":"COMPLETED","sponsor":"Abivax S.A.","startDate":"2019-08-13","conditions":"Ulcerative Colitis","enrollment":355},{"nctId":"NCT05324748","phase":"PHASE3","title":"Repeated GON Injections in CCH","status":"RECRUITING","sponsor":"Leiden University Medical Center","startDate":"2022-11-07","conditions":"Cluster Headache","enrollment":50},{"nctId":"NCT05724199","phase":"PHASE3","title":"A Study Assessing Rocatinlimab in Combination With Topical Corticosteroid and/or Topical Calcineurin Inhibitors in Adult Participants With Moderate-to-severe Atopic Dermatitis (AD)","status":"COMPLETED","sponsor":"Amgen","startDate":"2023-02-21","conditions":"Atopic Dermatitis","enrollment":746},{"nctId":"NCT06047171","phase":"PHASE2","title":"Rescue of Nephrons With ALE.F02 (RENAL-F02)","status":"RECRUITING","sponsor":"Alentis Therapeutics AG","startDate":"2023-09-07","conditions":"Glomerulonephritis Rapidly Progressive","enrollment":80},{"nctId":"NCT06027606","phase":"PHASE1","title":"Cardiovascular Consequences of Inhaled Short-acting Beta-agonist Use","status":"COMPLETED","sponsor":"University of Alberta","startDate":"2023-09-01","conditions":"Healthy","enrollment":81},{"nctId":"NCT05299086","phase":"PHASE3","title":"As Needed Versus Regular Intranasal Corticosteroid in Children With Perennial Allergic Rhinitis","status":"COMPLETED","sponsor":"Mahidol University","startDate":"2022-04-04","conditions":"Perennial Allergic Rhinitis, Child, Only","enrollment":68},{"nctId":"NCT04885530","phase":"PHASE3","title":"ACTIV-6: COVID-19 Study of Repurposed Medications","status":"COMPLETED","sponsor":"Susanna Naggie, MD","startDate":"2021-06-08","conditions":"Covid19","enrollment":10956},{"nctId":"NCT06453694","phase":"PHASE2","title":"Efgartigimod for the Treatment of Acute Optic Neuritis","status":"RECRUITING","sponsor":"Anastasia Vishnevetsky, MD, MPH","startDate":"2025-08-12","conditions":"Optic Neuritis","enrollment":20},{"nctId":"NCT03401398","phase":"PHASE3","title":"Stress Hydrocortisone In Pediatric Septic Shock","status":"RECRUITING","sponsor":"Jerry Zimmerman","startDate":"2019-03-11","conditions":"Septic Shock","enrollment":500},{"nctId":"NCT04843761","phase":"PHASE3","title":"ACTIV-3b: Therapeutics for Severely Ill Inpatients With COVID-19","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2021-04-20","conditions":"Covid19","enrollment":473},{"nctId":"NCT03584516","phase":"PHASE2, PHASE3","title":"GRAVITAS-309: Itacitinib and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease","status":"TERMINATED","sponsor":"Incyte Corporation","startDate":"2019-01-17","conditions":"Chronic Graft-versus-host Disease","enrollment":155},{"nctId":"NCT07191535","phase":"PHASE2","title":"Effect of Linvemastat in Patients With Partially Controlled Asthma (syMMPonia)","status":"NOT_YET_RECRUITING","sponsor":"Foresee Pharmaceuticals Co., Ltd.","startDate":"2026-01-01","conditions":"Asthma (Diagnosis), Pulmonary Function, Moderate-to-Severe Asthma","enrollment":135},{"nctId":"NCT04718389","phase":"PHASE3","title":"A Study of GSK3511294 (Depemokimab) Compared With Mepolizumab or Benralizumab in Participants With Severe Asthma With an Eosinophilic Phenotype","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2021-01-26","conditions":"Asthma","enrollment":1719},{"nctId":"NCT06280716","phase":"PHASE3","title":"A Study of Lebrikizumab (LY3650150) With/Without Topical Corticosteroid Treatment in Participants With Moderate-to-Severe Atopic Dermatitis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Eli Lilly and Company","startDate":"2024-04-24","conditions":"Atopic Dermatitis","enrollment":301},{"nctId":"NCT06143891","phase":"PHASE3","title":"A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease.","status":"ACTIVE_NOT_RECRUITING","sponsor":"Sanofi","startDate":"2024-01-23","conditions":"Chronic Graft Versus Host Disease","enrollment":260},{"nctId":"NCT06729593","phase":"PHASE3","title":"Remdesivir for Severely Ill Inpatients With COVID-19 (An ACTIV-3b/TESICO Treatment Trial)","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2021-04-20","conditions":"Covid19","enrollment":87},{"nctId":"NCT06729606","phase":"PHASE3","title":"Aviptadil for Severely Ill Inpatients With COVID-19 (An ACTIV-3b/TESICO Treatment Trial)","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2021-04-20","conditions":"Covid19","enrollment":471},{"nctId":"NCT04082533","phase":"PHASE4","title":"Intravenous (IV) Hydrocortisone for TKA (Total Knee Arthroplasty)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Hospital for Special Surgery, New York","startDate":"2019-07-24","conditions":"Pain, Arthrofibrosis, Osteoarthritis, Knee","enrollment":132},{"nctId":"NCT03228732","phase":"EARLY_PHASE1","title":"The Effects of Fluoxetine and/or DHEA","status":"RECRUITING","sponsor":"University of Maryland, Baltimore","startDate":"2017-12-19","conditions":"Type 1 Diabetes Mellitus","enrollment":60},{"nctId":"NCT06795906","phase":"PHASE1","title":"A Safety, Pharmacokinetic, and Pharmacodynamic Study of Once Daily Inhaled AZD8630 in Adults With Asthma","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2025-01-28","conditions":"Asthma","enrollment":24},{"nctId":"NCT04280497","phase":"NA","title":"Rapid Recognition of Corticosteroid Resistant or Sensitive Sepsis","status":"RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2020-04-10","conditions":"Sepsis","enrollment":1800},{"nctId":"NCT07189572","phase":"PHASE3","title":"Intranasal Corticosteroid Spray for Preventing Otitis Media With Effusion After Radiotherapy in Nasopharyngeal Carcinoma","status":"NOT_YET_RECRUITING","sponsor":"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","startDate":"2025-10","conditions":"Otitis Media, Otitis Media With Effusion After Nasopharyngeal Carcinoma, Radiotherapy Side Effects","enrollment":168},{"nctId":"NCT07181668","phase":"NA","title":"Effect of Low-Level Light Therapy on Ocular Surface Parameters in Patients Undergoing Femto-Lasik Surgery","status":"COMPLETED","sponsor":"Grigore T. Popa University of Medicine and Pharmacy","startDate":"2024-08-10","conditions":"Dry Eye, Meibomian Gland Dysfunction (Disorder), Ocular Surface Disease","enrollment":61},{"nctId":"NCT05878093","phase":"PHASE3","title":"Dupilumab in Chinese Adult Participants With CRSwNP","status":"COMPLETED","sponsor":"Sanofi","startDate":"2023-05-16","conditions":"Chronic Rhinosinusitis With Nasal Polyps","enrollment":63}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":310,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Methylprednisolone"],"phase":"phase_3","status":"active","brandName":"Placebo plus corticosteroid","genericName":"Placebo plus corticosteroid","companyName":"National Heart, Lung, and Blood Institute (NHLBI)","companyId":"national-heart-lung-and-blood-institute-nhlbi","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Corticosteroids are anti-inflammatory agents that reduce inflammation by suppressing the immune system's response. Used for Asthma, Chronic obstructive pulmonary disease (COPD).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}