{"id":"placebo-pills-and-injectables","safety":{"commonSideEffects":[{"rate":null,"effect":"Nocebo effect (adverse events attributed to placebo)"}]},"_chembl":{"chemblId":"CHEMBL1628401","moleculeType":"Small molecule","molecularWeight":"657.81"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Placebos are inert formulations used as controls in clinical trials and, in some clinical contexts, to harness the psychobiological placebo response. The therapeutic effect arises from patient expectation, conditioning, and the therapeutic relationship rather than from direct molecular interaction with disease pathways. Placebo responses can involve real neurobiological changes including endogenous opioid release and modulation of pain perception and other symptoms.","oneSentence":"Placebo pills and injectables contain no active pharmaceutical ingredient and work through the placebo effect, wherein patient expectation and the clinical context produce therapeutic benefit independent of pharmacological action.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:01:18.379Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Clinical trial control / comparator"},{"name":"Conditions responsive to placebo effect (e.g., pain, nausea, fatigue)"}]},"trialDetails":[{"nctId":"NCT07061574","phase":"PHASE1, PHASE2","title":"A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes","status":"RECRUITING","sponsor":"City of Hope Medical Center","startDate":"2026-03-30","conditions":"Type 1 Diabetes, New Onset","enrollment":120},{"nctId":"NCT04037605","phase":"EARLY_PHASE1","title":"Hormonal Mechanisms of Sleep Restriction - Axis Study in Older Men and Postmenopausal Women","status":"ACTIVE_NOT_RECRUITING","sponsor":"Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center","startDate":"2020-02-09","conditions":"Sleep Restriction","enrollment":5},{"nctId":"NCT03142893","phase":"PHASE1","title":"Hormonal Mechanisms of Sleep Restriction - Axis Study","status":"ACTIVE_NOT_RECRUITING","sponsor":"Peter y. 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Used for Clinical trial control / comparator, Conditions responsive to placebo effect (e.g., pain, nausea, fatigue).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}