{"id":"placebo-or-sugar-pill","safety":{"commonSideEffects":[{"rate":null,"effect":"Nocebo effect (negative expectation-induced symptoms)"}]},"_chembl":null,"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=Placebo or sugar pill","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T03:00:59.685812+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T03:01:05.246262+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=Placebo or sugar pill","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T03:01:05.466114+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201647/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:01:07.018051+00:00"}},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Placebos work by activating the patient's expectation and belief in treatment, which can modulate pain perception, immune function, and symptom severity through neurobiological pathways. The placebo effect involves both conscious psychological processes and unconscious physiological mechanisms, including endogenous opioid release and autonomic nervous system modulation. This effect is particularly pronounced in conditions with subjective symptom components such as pain, nausea, and fatigue.","oneSentence":"A placebo or sugar pill produces therapeutic effects through the placebo effect, wherein the expectation of treatment triggers physiological and psychological responses independent of any active pharmaceutical ingredient.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:36:13.680Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T03:01:08.597695+00:00","fieldsConflicting":0,"overallConfidence":0.95},"indications":{"approved":[{"name":"Research and clinical trial control arm (not a therapeutic indication)"}]},"trialDetails":[{"nctId":"NCT06063486","phase":"PHASE2","title":"Curcumin to Improve Inflammation and Symptoms in Patients With Clonal Cytopenia of Undetermined Significance, Low Risk Myelodysplastic Syndrome, and Myeloproliferative Neoplasms","status":"RECRUITING","sponsor":"University of Southern California","startDate":"2024-03-01","conditions":"Clonal Cytopenia of Undetermined Significance, Essential Thrombocythemia, Myelodysplastic Syndrome","enrollment":30},{"nctId":"NCT02064673","phase":"PHASE3","title":"Adjuvant Curcumin to Assess Recurrence Free Survival in Patients Who Have Had a Radical Prostatectomy","status":"RECRUITING","sponsor":"yair lotan","startDate":"2014-05","conditions":"Prostate Cancer","enrollment":608},{"nctId":"NCT04769206","phase":"PHASE1, PHASE2","title":"Enhancing Parasympathetic Activity to Improve Endothelial Dysfunction, Vascular Oxidative Stress in African Americans","status":"ACTIVE_NOT_RECRUITING","sponsor":"Vanderbilt University Medical Center","startDate":"2021-12-20","conditions":"Endothelial Dysfunction","enrollment":46},{"nctId":"NCT06720909","phase":"NA","title":"Mindfulness And Placebo for Pain (MAPP) Study","status":"RECRUITING","sponsor":"Arizona State University","startDate":"2025-01-27","conditions":"Chronic Pain","enrollment":45},{"nctId":"NCT06065670","phase":"PHASE1, PHASE2","title":"Assessing Changes in Multi-parametric MRI in Patients With Acute Demyelinating Lesions Taking Clemastine Fumarate as a Myelin Repair Therapy","status":"NOT_YET_RECRUITING","sponsor":"University of California, San Francisco","startDate":"2026-09-15","conditions":"Demyelinating Diseases, Demyelination; 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