{"id":"placebo-of-gastrodia-and-uncaria-granule","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":null,"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=Placebo of Gastrodia and Uncaria granule","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T04:50:11.596968+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T04:50:18.159827+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=Placebo of Gastrodia and Uncaria granule","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T04:50:18.965413+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL13829/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T04:50:19.888928+00:00"}},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Gastrodia elata and Uncaria rhynchophylla are traditional Chinese medicinal herbs used to treat hypertension by addressing the underlying imbalance of liver yang excess. The combination works through multiple pathways including vasodilation, reduction of sympathetic nervous system activity, and modulation of vascular smooth muscle tone. The mechanism is based on traditional Chinese medicine theory rather than a single molecular target.","oneSentence":"This herbal granule formulation combines Gastrodia and Uncaria to suppress liver yang hyperactivity and calm the spirit, thereby reducing hypertension.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:01:22.514Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T04:50:21.808635+00:00","fieldsConflicting":0,"overallConfidence":0.95},"indications":{"approved":[{"name":"Hypertension"},{"name":"Dizziness and headache associated with hypertension"}]},"trialDetails":[{"nctId":"NCT04035824","phase":"PHASE4","title":"Gastrodia and Uncaria Recipe in Treating Stage-one Hypertension: an Evidence-based Optimization Study","status":"COMPLETED","sponsor":"Shanghai Institute of Hypertension","startDate":"2019-10-08","conditions":"Hypertension","enrollment":605}],"_emaApprovals":[],"_faersSignals":[],"crossReferences":{"chemblId":"CHEMBL13829"},"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Placebo of Gastrodia and Uncaria granule","genericName":"Placebo of Gastrodia and Uncaria granule","companyName":"Shanghai Institute of Hypertension","companyId":"shanghai-institute-of-hypertension","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This herbal granule formulation combines Gastrodia and Uncaria to suppress liver yang hyperactivity and calm the spirit, thereby reducing hypertension. Used for Hypertension, Dizziness and headache associated with hypertension.","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":1,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T04:50:21.808635+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}