{"id":"placebo-of-folic-acid","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"}]},"_chembl":{"chemblId":"CHEMBL1622","moleculeType":"Small molecule","molecularWeight":"441.40"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Folic acid is essential for the production of red blood cells and the maintenance of healthy homocysteine levels in the blood. It also helps in the repair of damaged DNA and the synthesis of new DNA during cell division.","oneSentence":"Folic acid is a synthetic form of vitamin B9 that plays a crucial role in various bodily functions, including DNA synthesis and repair.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:28:12.871Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of neural tube defects in pregnant women"}]},"trialDetails":[{"nctId":"NCT07409272","phase":"PHASE3","title":"A Study to Evaluate the Effectiveness and Safety of Setidegrasib, Given With Either mFOLFIRINOX or NALIRIFOX Chemotherapies, in People With Pancreatic Cancer","status":"RECRUITING","sponsor":"Astellas Pharma Global Development, Inc.","startDate":"2026-02-17","conditions":"Pancreatic Cancer, Metastatic Pancreatic Cancer, Metastatic Pancreatic Adenocarcinoma","enrollment":614},{"nctId":"NCT07486141","phase":"NA","title":"Effect of Vitamin D and Folic Acid on Mild Cognitive Impairment","status":"ACTIVE_NOT_RECRUITING","sponsor":"Capital Medical University","startDate":"2024-11-01","conditions":"Mild Cognitive Impairment","enrollment":380},{"nctId":"NCT06901531","phase":"PHASE3","title":"A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric Cancer","status":"RECRUITING","sponsor":"Astellas Pharma Global Development, Inc.","startDate":"2025-05-22","conditions":"Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer, Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer, Metastatic Gastric Adenocarcinoma or Cancer","enrollment":500},{"nctId":"NCT06654089","phase":"PHASE4","title":"A Study Evaluating Quality of Life Parameters Following Use of Emergen-C","status":"COMPLETED","sponsor":"HALEON","startDate":"2024-10-30","conditions":"Dietary Supplements","enrollment":299},{"nctId":"NCT03221426","phase":"PHASE3","title":"Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Participants With Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-585/KEYNOTE-585)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2017-10-09","conditions":"Gastric Cancer, Gastroesophageal Junction Cancer","enrollment":1007},{"nctId":"NCT04882241","phase":"PHASE3","title":"Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Participants With Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-585/KEYNOTE-585)-China Extension","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2020-07-29","conditions":"Gastric Cancer, Gastroesophageal Junction Cancer","enrollment":120},{"nctId":"NCT06979180","phase":"NA","title":"A Clinical Trial to Investigate the Safety and Efficacy of Papillex® on Abnormal Cervical Cells Caused by HPV.","status":"RECRUITING","sponsor":"Papillex Inc.","startDate":"2026-03","conditions":"CIN - Cervical Intraepithelial Neoplasia, CIN 1, CIN 2","enrollment":60},{"nctId":"NCT06697626","phase":"NA","title":"Validation of a Novel Functional Food Designed to Meet the Nutritional Needs of People Living With Parkinson's Disease","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Ulster","startDate":"2024-11-14","conditions":"Constipation, Parkinson Disease","enrollment":56},{"nctId":"NCT05983367","phase":"PHASE2","title":"A Study to Investigate Ompenaclid Combined With FOLFIRI Plus Bevacizumab in Advanced/Metastatic Colorectal Cancer","status":"TERMINATED","sponsor":"Inspirna, Inc.","startDate":"2023-10-10","conditions":"Colorectal Cancer, Metastatic Colon Cancer","enrollment":76},{"nctId":"NCT03504397","phase":"PHASE3","title":"A Study to Compare Zolbetuximab (IMAB362) and Chemotherapy With Placebo and Chemotherapy in Adults With Gastric Cancer.","status":"ACTIVE_NOT_RECRUITING","sponsor":"Astellas Pharma Global Development, Inc.","startDate":"2018-06-21","conditions":"Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer, Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer, Metastatic Gastric Adenocarcinoma or Cancer","enrollment":565},{"nctId":"NCT07380438","phase":"NA","title":"A Clinical Study to Evaluate the Efficacy of a Nutritional Supplement to Improve Carotenoid Content as Measured by a Non-invasive Hyperspectral Absorption Device","status":"COMPLETED","sponsor":"Pharmanex","startDate":"2025-10-20","conditions":"Nutrition Assessment","enrollment":84},{"nctId":"NCT07113158","phase":"PHASE3","title":"Effect of Aspirin and Folic Acid for Sudden Sensorineural Hearing Loss","status":"NOT_YET_RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2026-04-01","conditions":"Sudden Sensorineural Hearing Loss","enrollment":142},{"nctId":"NCT07271316","phase":"PHASE2","title":"Alii Supplement Study","status":"RECRUITING","sponsor":"Texas Christian University","startDate":"2026-01-12","conditions":"Nutrient Deficiency, Happiness, Digestive Health","enrollment":68},{"nctId":"NCT07312435","phase":"NA","title":"B-vitamins and Omega-3 Fatty Acids and Biomarkers of Brain Atrophy.","status":"RECRUITING","sponsor":"University of Oslo","startDate":"2025-09-01","conditions":"Dementia, Cognitive Function","enrollment":96},{"nctId":"NCT03875755","phase":"NA","title":"Myo-inositol for Reduction of Insulin Therapy in Gestational Diabetes Mellitus","status":"ACTIVE_NOT_RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2020-03-04","conditions":"Gestational Diabetes Mellitus","enrollment":1080},{"nctId":"NCT04579848","phase":"PHASE4","title":"Methotrexate in Erosive Inflammatory Hand Osteoarthritis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Diakonhjemmet Hospital","startDate":"2021-08-12","conditions":"Hand Osteoarthritis, Erosive Osteoarthritis","enrollment":163},{"nctId":"NCT04483466","phase":"PHASE3","title":"Methotrexate Treatment of Arthritis Caused by Chikungunya Virus (MARCH)","status":"ACTIVE_NOT_RECRUITING","sponsor":"George Washington University","startDate":"2023-07-18","conditions":"Investigate the Effect(s) of Methotrexate Treatment on Arthritis Disease Severity","enrollment":150},{"nctId":"NCT04670393","phase":"NA","title":"Antioxidant Supplement Associated With Oral Probiotics in Patients With PCOS in IVF","status":"COMPLETED","sponsor":"Fertypharm","startDate":"2020-12-02","conditions":"Infertility, Female, Polycystic Ovary Syndrome","enrollment":20},{"nctId":"NCT06639074","phase":"PHASE2","title":"Folate Receptor Alpha Dendritic Cells (FRαDCs) or Placebo for the Treatment of Patients With Stage III or IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer, FAROUT Trial","status":"RECRUITING","sponsor":"Mayo Clinic","startDate":"2024-11-08","conditions":"Advanced Fallopian Tube Carcinoma, Advanced Fallopian Tube High Grade Serous Adenocarcinoma, Advanced Ovarian Carcinoma","enrollment":78},{"nctId":"NCT06081114","phase":"NA","title":"Micronutrient Dose Response Study in Bangladesh","status":"ACTIVE_NOT_RECRUITING","sponsor":"Johns Hopkins Bloomberg School of Public Health","startDate":"2023-10-22","conditions":"Micronutrient Status","enrollment":643},{"nctId":"NCT02378246","phase":"NA","title":"Swedish Iodine in Pregnancy and Development in Children (SWIDDICH) Study","status":"ACTIVE_NOT_RECRUITING","sponsor":"Göteborg University","startDate":"2012-11","conditions":"Thyroid Gland; Node, Pregnancy, Cognitive Developmental Delay","enrollment":1337},{"nctId":"NCT04959864","phase":"NA","title":"Efficacy Study of a Food Supplement With Myo-inositol, N-Acetyl-Cystein, Zinc and Vitamins on Sperm DNA Fragmentation","status":"RECRUITING","sponsor":"GYNOV","startDate":"2021-07-07","conditions":"Male Infertility","enrollment":72},{"nctId":"NCT07021495","phase":"","title":"SKIN Disease Profiling by an Exploratory, pRospective, Biomarker Study in dermatoloGY Practice (SKINERGY)","status":"RECRUITING","sponsor":"Leiden University Medical Center","startDate":"2025-07-29","conditions":"Chronic Spontaneous Urticaria (CSU), Hidradenitis Suppurativa (HS), Psoriasis (PsO)","enrollment":840},{"nctId":"NCT06347315","phase":"NA","title":"Evaluation of the Effects of a Nutritional Intervention of Ketogenic Medium-chain Triglycerides and B-vitamins on Cognitive Functioning in Older Adults With Mild Cognitive Impairment (COGNIKET-MCI)","status":"RECRUITING","sponsor":"Société des Produits Nestlé (SPN)","startDate":"2024-05-24","conditions":"Mild Cognitive Impairment","enrollment":380},{"nctId":"NCT05682261","phase":"NA","title":"The Effect of Multiple Micronutrient Supplements in Reducing Anemia in Women of Reproductive Age","status":"COMPLETED","sponsor":"Ethiopian Public Health Institute","startDate":"2023-03-23","conditions":"Anemia","enrollment":265},{"nctId":"NCT06349616","phase":"NA","title":"Cooling Strategies for Older Adults in the Heat","status":"COMPLETED","sponsor":"Penn State University","startDate":"2024-05-01","conditions":"Aging","enrollment":12},{"nctId":"NCT07048860","phase":"NA","title":"ICOPE INTENSE-K Pilot Study","status":"RECRUITING","sponsor":"University Hospital, Toulouse","startDate":"2025-07-09","conditions":"Ageing","enrollment":40},{"nctId":"NCT07028424","phase":"PHASE2","title":"PANORAMIX : Optimizing 1st-line NALIRIFOX and Exploring Microbiota's Role in 2nd Line Pancreatic Cancer Treatment","status":"NOT_YET_RECRUITING","sponsor":"GERCOR - Multidisciplinary Oncology Cooperative Group","startDate":"2025-07","conditions":"PDAC - Pancreatic Ductal Adenocarcinoma","enrollment":206},{"nctId":"NCT06055179","phase":"NA","title":"XCHT for Irinotecan-Induced Gut Toxicities (Randomized Controlled Trial)","status":"RECRUITING","sponsor":"Guangzhou University of Traditional Chinese Medicine","startDate":"2024-03-08","conditions":"Xiao Chai Hu Tang, Irinotecan-induced Diarrhea","enrollment":98},{"nctId":"NCT06264570","phase":"NA","title":"Evaluation of a Genetically Determined Personalized Approach in Prescribing Biologically Active Substances in Patients With Elevated Blood Homocysteine Levels.","status":"RECRUITING","sponsor":"S.LAB (SOLOWAYS)","startDate":"2023-10-23","conditions":"Hyperhomocysteinemia","enrollment":111},{"nctId":"NCT05712356","phase":"PHASE2","title":"A Study of LSTA1 When Added to Standard of Care Versus Standard of Care Alone in Patients With Advanced Solid Tumors","status":"ACTIVE_NOT_RECRUITING","sponsor":"Lisata Therapeutics, Inc.","startDate":"2023-08-24","conditions":"Cholangiocarcinoma, Gallbladder Cancer, Gallbladder Carcinoma","enrollment":67},{"nctId":"NCT04060030","phase":"PHASE2","title":"Treatment of Social and Language Deficits With Leucovorin for Young Children With Autism","status":"RECRUITING","sponsor":"Southwest Autism Research & Resource Center","startDate":"2020-10-08","conditions":"Autism Spectrum Disorder, Language Disorders","enrollment":80},{"nctId":"NCT04060017","phase":"PHASE2","title":"Early Treatment of Language Impairment in Young Children With Autism Spectrum Disorder With Leucovorin Calcium","status":"RECRUITING","sponsor":"Southwest Autism Research & Resource Center","startDate":"2020-09-22","conditions":"Autism Spectrum Disorder, Language Disorders","enrollment":80},{"nctId":"NCT02839915","phase":"PHASE2","title":"Leucovorin for the Treatment of Language Impairment in Children With Autism Spectrum Disorder","status":"ACTIVE_NOT_RECRUITING","sponsor":"Southwest Autism Research & Resource Center","startDate":"2020-08-13","conditions":"Autism Spectrum Disorder","enrollment":56},{"nctId":"NCT05624138","phase":"PHASE3","title":"The Possible Protective Role of Ketotifen Against Oxaliplatin Induced Peripheral Neuropathy","status":"RECRUITING","sponsor":"Tanta University","startDate":"2022-11-09","conditions":"Neuropathy;Peripheral","enrollment":64},{"nctId":"NCT06281184","phase":"","title":"A 30-month Follow-up of MERINO Participants to Evaluate Long-term Effects of Methotrexate in Erosive Hand OA.","status":"ENROLLING_BY_INVITATION","sponsor":"Diakonhjemmet Hospital","startDate":"2024-07-29","conditions":"Hand Osteoarthritis, Erosive Osteoarthritis","enrollment":108},{"nctId":"NCT06940557","phase":"PHASE2, PHASE3","title":"Efficacy And Tolerability Of Alpha Lipoic Acid And Vitamin B Preparation In Carpal Tunnel Syndrome","status":"COMPLETED","sponsor":"Universiti Putra Malaysia","startDate":"2023-12-01","conditions":"Carpal Tunnel Syndrome (CTS)","enrollment":70},{"nctId":"NCT04881851","phase":"NA","title":"Effects of Inositol Alone or Associated With Alpha-lipoic Acid in Polycystic Ovary Syndrome Treatment","status":"TERMINATED","sponsor":"Universita di Verona","startDate":"2015-05-07","conditions":"Polycystic Ovary Syndrome","enrollment":76},{"nctId":"NCT04343170","phase":"NA","title":"Effect of Ultra-short-term Treatment of Patients With Iron Deficiency or Anemia Undergoing Adolescent Scoliosis Correction","status":"COMPLETED","sponsor":"Tanta University","startDate":"2023-09-01","conditions":"Ultra-short-term, Iron Deficiency Anemia, Scoliosis Idiopathic","enrollment":44},{"nctId":"NCT06930144","phase":"NA","title":"5-MTHF Supplementation for Treatment of Type 1 Diabetes Patients","status":"NOT_YET_RECRUITING","sponsor":"Shanghai Changzheng Hospital","startDate":"2025-04","conditions":"Type 1 Diabetes Mellitus","enrollment":34},{"nctId":"NCT06516094","phase":"PHASE3","title":"Efficacy and Safety in the Combination of Celecoxib / Pregabalin / Vitamin B for Low Back Chronic Pain","status":"COMPLETED","sponsor":"Laboratorios Silanes S.A. de C.V.","startDate":"2024-04-11","conditions":"Chronic Low-back Pain","enrollment":192},{"nctId":"NCT03337360","phase":"NA","title":"The Impact of a Nutritional Supplement (Impryl®) on Male Fertility","status":"ACTIVE_NOT_RECRUITING","sponsor":"Radboud University Medical Center","startDate":"2018-04-23","conditions":"Male Subfertility","enrollment":1200},{"nctId":"NCT05638633","phase":"PHASE3","title":"Prednisolone and Vitamin B1/6/12 in Patients With Post-Covid-Syndrome","status":"COMPLETED","sponsor":"Wuerzburg University Hospital","startDate":"2022-11-11","conditions":"Post-COVID-19 Syndrome","enrollment":321},{"nctId":"NCT01239693","phase":"PHASE3","title":"Supplementing Maternal and Infant Diet With High-energy, Micronutrient Fortified Lipid-based Nutrient Supplements (LNS)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Tampere University","startDate":"2011-02","conditions":"Infant Malnutrition, Malnutrition in Pregnancy","enrollment":1391},{"nctId":"NCT06163443","phase":"NA","title":"Evaluating the Impact of B Vitamin Supplementation (Soloways™) on Homocysteine and LDL-C Levels in Patients With MTHFR, MTR, and MTRR Polymorphisms.","status":"COMPLETED","sponsor":"S.LAB (SOLOWAYS)","startDate":"2022-03-02","conditions":"Hyperhomocysteinemia, Hyperlipoproteinemias","enrollment":54},{"nctId":"NCT06718426","phase":"NA","title":"Evaluation of Fertitonex Effects on Semen Parameters in Clinical Varicocele Patient.","status":"RECRUITING","sponsor":"Menoufia University","startDate":"2024-12-01","conditions":"Varicocele","enrollment":110},{"nctId":"NCT03581773","phase":"PHASE2","title":"Folic Acid Supplement Versus Placebo for Treating Mucositis Adverse Events in Metastatic Renal Cell Carcinoma Patients Receiving Targeted Therapy","status":"RECRUITING","sponsor":"Niels Fristrup","startDate":"2017-12-20","conditions":"Mucositis, Stomatitis","enrollment":100},{"nctId":"NCT02947750","phase":"PHASE2","title":"Neurovascular Transduction During Exercise in Chronic Kidney Disease","status":"RECRUITING","sponsor":"Emory University","startDate":"2016-10","conditions":"Renal Insufficiency, Chronic","enrollment":150},{"nctId":"NCT06857734","phase":"NA","title":"Analgesic and Anti-inflamatory Effect of Vit. B","status":"NOT_YET_RECRUITING","sponsor":"Benha University","startDate":"2025-03-01","conditions":"Postoperative Pain, Acute","enrollment":90},{"nctId":"NCT04825288","phase":"PHASE1, PHASE2","title":"XB2001 in Combination With ONIVYDE + 5-FU/LV (+Folinic Acid) in Advanced Pancreatic Cancer","status":"ACTIVE_NOT_RECRUITING","sponsor":"XBiotech, Inc.","startDate":"2021-05-27","conditions":"Pancreatic Cancer","enrollment":76},{"nctId":"NCT04974138","phase":"PHASE4","title":"China Stroke Primary Prevention Trial 2 for Participants With H-type Hypertension and MTHFR 677 CC/CT Genotype (CSPPT2-CC/CT)","status":"RECRUITING","sponsor":"Shenzhen Ausa Pharmed Co.,Ltd","startDate":"2024-08-22","conditions":"Hypertension, MTHFR 677 CC or CT Genotype, Elevated Plasma Homocysteine (Hcy≥10µmol/L)","enrollment":32000},{"nctId":"NCT04974151","phase":"PHASE4","title":"China Stroke Primary Prevention Trial 2 for Participants With Hypertension and MTHFR 677 TT Genotype","status":"RECRUITING","sponsor":"Shenzhen Ausa Pharmed Co.,Ltd","startDate":"2024-08-22","conditions":"Hypertension, MTHFR 677 TT Genotype","enrollment":24000},{"nctId":"NCT06446830","phase":"NA","title":"The Analgesic Efficacy of Vitamin B Complex in Critically Ill Obstetrics After Caesarean Section","status":"RECRUITING","sponsor":"Ain Shams University","startDate":"2024-05-25","conditions":"Analgesia, Post Operative Pain, Cesarean Section","enrollment":100},{"nctId":"NCT04893733","phase":"PHASE4","title":"Intravenous Administration of Vitamin B Complex Improves Renal Recovery in Patients With AKI","status":"COMPLETED","sponsor":"Caja Nacional de Salud","startDate":"2020-09-01","conditions":"Acute Kidney Injury","enrollment":260},{"nctId":"NCT06479629","phase":"PHASE4","title":"The Effect of Piracetam on Diabetic Peripheral Neuropathy Patients","status":"NOT_YET_RECRUITING","sponsor":"Ain Shams University","startDate":"2025-02-10","conditions":"Diabetic Peripheral Neuropathy","enrollment":60},{"nctId":"NCT05363891","phase":"PHASE2","title":"Natrunix or Placebo in Combination With Methotrexate in Rheumatoid Arthritis","status":"COMPLETED","sponsor":"XBiotech, Inc.","startDate":"2023-08-08","conditions":"Rheumatoid Arthritis","enrollment":243},{"nctId":"NCT06774885","phase":"PHASE3","title":"ROLE OF FOLIC ACID IN THE MANAGEMENT OF ADJUVANT ENDOCRINE THERAPY-INDUCED HOT FLASHES IN BREAST CANCER PATIENTS","status":"NOT_YET_RECRUITING","sponsor":"Future University in Egypt","startDate":"2025-02-09","conditions":"THERAPY-INDUCED HOT FLASHES IN BREAST CANCER PATIENTS","enrollment":120},{"nctId":"NCT04016090","phase":"NA","title":"An Evaluation of Folic Acid to Improve Endothelial Sensitivity to Shear Stress in Seniors","status":"COMPLETED","sponsor":"Montreal Heart Institute","startDate":"2019-09-09","conditions":"Healthy Aging, Aging, Menopause","enrollment":44},{"nctId":"NCT05656729","phase":"NA","title":"Effect of a Multistrain Probiotic on Cold Symptoms in Healthy Patients with an History of Upper Airways Infection","status":"COMPLETED","sponsor":"Università degli Studi di Ferrara","startDate":"2022-12-22","conditions":"Cold Symptom","enrollment":50},{"nctId":"NCT03697733","phase":"NA","title":"Comparison Efficiency of Oral Etoricoxib Versus Intravenous Fentanyl on Post Operative Pain in Curettage Under TIVA","status":"COMPLETED","sponsor":"Department of Medical Services Ministry of Public Health of Thailand","startDate":"2018-11-01","conditions":"Abnormal Uterine Bleeding","enrollment":60},{"nctId":"NCT04210115","phase":"PHASE3","title":"Study of Pembrolizumab (MK-3475) Versus Placebo in Participants With Esophageal Carcinoma Who Are Receiving Chemotherapy and Radiation Therapy (MK-3475-975/KEYNOTE-975)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Merck Sharp & Dohme LLC","startDate":"2020-02-28","conditions":"Esophageal Squamous Cell Carcinoma (ESCC), Gastroesophageal Junction Carcinoma (GEJC), Esophageal Adenocarcinoma (EAC)","enrollment":703},{"nctId":"NCT03941093","phase":"PHASE3","title":"Evaluation of Efficacy and Safety of Neoadjuvant Treatment With Pamrevlumab in Combination With Chemotherapy (Either Gemcitabine Plus Nab-paclitaxel or FOLFIRINOX) in Participants With Locally Advanced, Unresectable Pancreatic Cancer","status":"COMPLETED","sponsor":"Kyntra Bio","startDate":"2019-05-10","conditions":"Pancreatic Cancer Non-resectable","enrollment":284},{"nctId":"NCT06174441","phase":"NA","title":"The Effect of 24-week Dietary Intake of Food Supplements on Hair","status":"COMPLETED","sponsor":"VIST - Faculty of Applied Sciences","startDate":"2024-01-08","conditions":"Hair Thinning, Hair Loss","enrollment":89},{"nctId":"NCT05607056","phase":"NA","title":"Efficacy and Safety of Sinquanon for Prevention of Antibiotic-associated Diarrhea in Adults","status":"COMPLETED","sponsor":"Neopharm Bulgaria Ltd.","startDate":"2022-11-27","conditions":"Antibiotic-associated Diarrhea","enrollment":565},{"nctId":"NCT04723134","phase":"PHASE2","title":"Evaluation of a Folic Acid Wound Treatment (FAWT) for Chronic, Early-Stage Diabetic Foot Ulcer (DFU) Healing","status":"COMPLETED","sponsor":"Joseph Boykin, MD","startDate":"2021-12-01","conditions":"Diabetic Foot Ulcer","enrollment":15},{"nctId":"NCT02578680","phase":"PHASE3","title":"Study of Pemetrexed+Platinum Chemotherapy With or Without Pembrolizumab (MK-3475) in Participants With First Line Metastatic Nonsquamous Non-small Cell Lung Cancer (MK-3475-189/KEYNOTE-189)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2016-01-15","conditions":"Non-Small-Cell Lung Carcinoma","enrollment":616},{"nctId":"NCT06576739","phase":"NA","title":"B Vitamin Supplementation to Chiropractic Management of Chronic LBP: Pilot Clinical Trial (VCLBP)","status":"NOT_YET_RECRUITING","sponsor":"University of Western States","startDate":"2024-11-15","conditions":"Recurrent Low Back Pain","enrollment":60},{"nctId":"NCT02705300","phase":"PHASE2","title":"Side Effects to FOLFOXIRI + Tocotrienol/Placebo as First Line Treatment of Metastatic Colorectal Cancer","status":"COMPLETED","sponsor":"Vejle Hospital","startDate":"2016-05-06","conditions":"Colorectal Cancer","enrollment":70},{"nctId":"NCT06568185","phase":"PHASE2","title":"The Effect of Alpha Lipoid Acid and Vitamin B Preparation on Diabetic Polyneuropathy in Type 2 Diabetes Mellitus Patient","status":"RECRUITING","sponsor":"Universiti Sains Malaysia","startDate":"2024-05-27","conditions":"Diabetic Polyneuropathy","enrollment":76},{"nctId":"NCT06523218","phase":"NA","title":"A Clinical Trial to Investigate the Efficacy of a Supplement to Improve and Maintain Cognitive Function and Memory","status":"ACTIVE_NOT_RECRUITING","sponsor":"Scale Media Inc","startDate":"2024-05-17","conditions":"Cognitive Decline, Cognitive Function","enrollment":50},{"nctId":"NCT06481696","phase":"NA","title":"Possible Action of Resveratrol in Improving the Outcomes of IVF/ICSI in Couples With Unexplained Infertility","status":"RECRUITING","sponsor":"Andros Day Surgery Clinic","startDate":"2024-06-01","conditions":"Unexplained Infertility","enrollment":90},{"nctId":"NCT03994731","phase":"PHASE4","title":"Study of KRYSTEXXA® (Pegloticase) Plus Methotrexate in Participants With Uncontrolled Gout","status":"COMPLETED","sponsor":"Amgen","startDate":"2019-06-13","conditions":"Gout","enrollment":152},{"nctId":"NCT05675007","phase":"NA","title":"Effects of a Colon-delivered Multivitamin Supplement on Brain Functioning, Immunometabolic- and Intestinal Markers in Ageing","status":"COMPLETED","sponsor":"Donders Centre for Cognitive Neuroimaging","startDate":"2022-12-05","conditions":"Cognitive Decline, Aging","enrollment":75},{"nctId":"NCT03950674","phase":"PHASE3","title":"Study of Pemetrexed+Platinum Chemotherapy With or Without Pembrolizumab (MK-3475) in Participants With First Line Metastatic Nonsquamous Non-small Cell Lung Cancer (MK-3475-189/KEYNOTE-189)-Japan Extension Study","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2016-02-22","conditions":"Non-Small-Cell Lung Carcinoma","enrollment":40},{"nctId":"NCT06444243","phase":"PHASE2","title":"Psilocybin-assisted Therapy for Alcohol Use Disorder","status":"NOT_YET_RECRUITING","sponsor":"University of Sydney","startDate":"2024-09","conditions":"Alcohol Use Disorder, Alcohol Dependence, Depression","enrollment":90},{"nctId":"NCT03981029","phase":"","title":"FACT Biomarker Subgroup Analysis","status":"COMPLETED","sponsor":"Ottawa Hospital Research Institute","startDate":"2011-12-19","conditions":"Pre-Eclampsia","enrollment":51},{"nctId":"NCT06413043","phase":"NA","title":"Study on Efficacy of Add on Selenium in Mild-to-moderate Graves Ophthalmopathy","status":"NOT_YET_RECRUITING","sponsor":"All India Institute of Medical Sciences, Bhubaneswar","startDate":"2024-05-06","conditions":"Thyroid Eye Disease, Graves Ophthalmopathy","enrollment":78},{"nctId":"NCT06403748","phase":"NA","title":"Effect of a Dietary Supplement on Lipid Pattern, Indexes of NAFLD and Systemic Inflammation in Healthy Subjects With Suboptimal LDL-C Levels","status":"NOT_YET_RECRUITING","sponsor":"University of Bologna","startDate":"2024-05-06","conditions":"Hypercholesterolemia, Inflammation","enrollment":90},{"nctId":"NCT05097365","phase":"NA","title":"Methyl-donor Nutrient Supplementation and Methylation Profile in Lupus Patients With Obesity","status":"ENROLLING_BY_INVITATION","sponsor":"University of Sao Paulo","startDate":"2022-01-01","conditions":"Overweight and Obesity, Lupus Erythematosus","enrollment":51},{"nctId":"NCT06247137","phase":"NA","title":"Effect of a Food Supplementation With a Combined Food Supplement on Lipid Pattern, Indexes of Non-alcoholic Fatty Liver Disease and Systemic Inflammation","status":"COMPLETED","sponsor":"University of Bologna","startDate":"2022-04-01","conditions":"Hypercholesterolemia","enrollment":90},{"nctId":"NCT06363565","phase":"NA","title":"Effects of Supplementation of Compound Nutrients on Plasma Homocysteine in Chinese Adults","status":"RECRUITING","sponsor":"Sun Yat-sen University","startDate":"2023-06-01","conditions":"Homocysteine","enrollment":220},{"nctId":"NCT04751669","phase":"NA","title":"Efficacy of a Dietary Supplementation in Reducing Hospital Admissions for COVID-19. Randomized Clinical Trial","status":"COMPLETED","sponsor":"Fundació Institut Germans Trias i Pujol","startDate":"2021-08-09","conditions":"Covid19","enrollment":252},{"nctId":"NCT06277635","phase":"NA","title":"Effect of Silymarin Against Methotrexate-induced Liver Injury in Rheumatic Diseases","status":"UNKNOWN","sponsor":"Phramongkutklao College of Medicine and Hospital","startDate":"2024-02-01","conditions":"Rheumatoid Arthritis, Psoriatic Arthritis, Psoriasis","enrollment":72},{"nctId":"NCT04832178","phase":"PHASE4","title":"Sumor as Adjuvant Therapy in Treatment-resistant Major Depression","status":"UNKNOWN","sponsor":"Azienda Ospedaliero-Universitaria Careggi","startDate":"2021-06-01","conditions":"Major Depressive Disorder","enrollment":102},{"nctId":"NCT06235294","phase":"NA","title":"Effects of Resveratrol Supplementation on Oocyte Quality","status":"UNKNOWN","sponsor":"Unidade Local de Saúde de Coimbra, EPE","startDate":"2024-09","conditions":"Aging, Infertility","enrollment":88},{"nctId":"NCT05380934","phase":"PHASE1","title":"A Clinical Trial of Safety and Tolerance of TQH3821 Tablets in Adult Healthy Subjects","status":"COMPLETED","sponsor":"Chia Tai Tianqing Pharmaceutical Group Co., Ltd.","startDate":"2022-05-29","conditions":"Rheumatoid Arthritis","enrollment":63},{"nctId":"NCT03371667","phase":"PHASE3","title":"To Compare the Efficacy of the Addition of Methotrexate (MTX) to Current Standard Acute Graft-versus-host Disease (GVHD) First-line Treatment With Corticosteroids","status":"UNKNOWN","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2018-08-16","conditions":"Allogeneic Disease, GVH - Graft Versus Host Reaction, GVHD, Acute","enrollment":102},{"nctId":"NCT02133521","phase":"PHASE2, PHASE3","title":"DLBS1033 for Acute Ischemic Stroke Patients","status":"TERMINATED","sponsor":"Dexa Medica Group","startDate":"2014-11-11","conditions":"Acute Ischemic Stroke, Partial Anterior Circulation Infarct, Lacunar Anterior Circulation Infarct","enrollment":80},{"nctId":"NCT06004570","phase":"NA","title":"Effects of a Combination of Polyphenol-rich Extracts on the Protection of Retinal Cells Against Blue Light in the Prevention of Ocular Diseases","status":"COMPLETED","sponsor":"AronPharma Sp. z o. o.","startDate":"2023-06-15","conditions":"Eye Abnormalities","enrollment":22},{"nctId":"NCT05959044","phase":"PHASE2","title":"Effect of Folic Acid in Levodopa Treated Parkinson's Disease Patients","status":"UNKNOWN","sponsor":"Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh","startDate":"2023-04-16","conditions":"Parkinson Disease","enrollment":60},{"nctId":"NCT05988099","phase":"NA","title":"Comparison of the Effects of Standardized Chokeberry Extracts With Various Formulations on the Levels of Selected Markers Associated With Cardiovascular Disease","status":"COMPLETED","sponsor":"AronPharma Sp. z o. o.","startDate":"2023-02-20","conditions":"Hypertension, Hypercholesterolemia","enrollment":40},{"nctId":"NCT05389813","phase":"PHASE2, PHASE3","title":"Comparison Between Oxycodone and Pregabalin as Preemptive Analgesia","status":"UNKNOWN","sponsor":"An-Najah National University","startDate":"2021-08-15","conditions":"Anesthesia","enrollment":150},{"nctId":"NCT00002650","phase":"PHASE2","title":"High-Dose Folic Acid in Preventing Colorectal Cancer in Patients Who Have Had Polyps Surgically Removed","status":"COMPLETED","sponsor":"Eastern Cooperative Oncology Group","startDate":"1995-06-12","conditions":"Colorectal Cancer","enrollment":80},{"nctId":"NCT02270632","phase":"PHASE2","title":"A Randomized, Placebo-controlled Phase II Clinical Trial to Evaluate the Safety and Efficacy of F8IL10 (Dekavil) in Patients With Active RA Receiving MTX","status":"TERMINATED","sponsor":"Philogen S.p.A.","startDate":"2014-10-01","conditions":"Rheumatoid Arthritis","enrollment":27},{"nctId":"NCT05880589","phase":"NA","title":"Efficacy and Safety of Milk Secretory Supplement in Breast-feeding Volunteers","status":"UNKNOWN","sponsor":"Chulalongkorn University","startDate":"2022-12-08","conditions":"Lactation","enrollment":24},{"nctId":"NCT02344810","phase":"PHASE1, PHASE2","title":"C-Met Inhibitor AMG 337, Oxaliplatin, Leucovorin Calcium, and Fluorouracil in Treating Patients With Advanced Stomach or Esophageal Cancer","status":"WITHDRAWN","sponsor":"Eastern Cooperative Oncology Group","startDate":"2015-03-06","conditions":"Adenocarcinoma of the Esophagus, Adenocarcinoma of the Gastroesophageal Junction, Diffuse Adenocarcinoma of the Stomach","enrollment":""},{"nctId":"NCT05861648","phase":"PHASE2","title":"Folic Acid Supplementation in Calcific Aortic Valve Disease","status":"NOT_YET_RECRUITING","sponsor":"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","startDate":"2023-07-01","conditions":"Calcification of Aortic Valve, Aortic Valve Stenosis","enrollment":100},{"nctId":"NCT05819983","phase":"PHASE4","title":"Ivermectin/ Permethrin for Scabies","status":"COMPLETED","sponsor":"Universitas Padjadjaran","startDate":"2023-01-25","conditions":"Scabies","enrollment":60},{"nctId":"NCT03431974","phase":"PHASE2","title":"Once-Weekly Oral Aminopterin for the Treatment of Subjects With Moderate-To-Severe Psoriasis","status":"COMPLETED","sponsor":"Syntrix Biosystems, Inc.","startDate":"2018-11-01","conditions":"Psoriasis","enrollment":19},{"nctId":"NCT02772965","phase":"PHASE3","title":"Low Dose Oral Methotrexate in Pediatric Crohn's Disease Patients Initiating Anti-Tumor Necrosis Factor (Anti-TNF) Therapy","status":"COMPLETED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2016-10","conditions":"Pediatric Crohn's Disease","enrollment":306}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"placebo of folic acid","genericName":"placebo of folic acid","companyName":"Assistance Publique - Hôpitaux de Paris","companyId":"assistance-publique-h-pitaux-de-paris","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Folic acid is a synthetic form of vitamin B9 that plays a crucial role in various bodily functions, including DNA synthesis and repair. Used for Prevention of neural tube defects in pregnant women.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}